Search Results - "Pańczyk, Katarzyna"

Design, synthesis and activity against Staphylococcus epidermidis of 5‐chloro‐2‐ or 5‐chloro‐4‐methyl‐9H‐xanthen‐9‐one and some of its derivatives by Mazur, Gabriela, Skiba‐Kurek, Iwona, Karczewska, Elżbieta, Pańczyk‐Straszak, Katarzyna, Jaworska, Joanna, Waszkielewicz, Anna M.

“…Ten new xanthone derivatives have been designed and synthesized for their potential antibacterial activity. All compounds have been screened against…”
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Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation by Mazur, Gabriela, Pańczyk‐Straszak, Katarzyna, Rapacz, Anna, Kiszela, Jan, Smolik, Magdalena, Gawlik, Maciej, Walczak, Maria, Czekajewska, Joanna, Poloczek, Celina, Karczewska, Elżbieta, Żesławska, Ewa, Nitek, Wojciech, Niedbał, Anna, Leśniak, Joanna, Ciapala, Katarzyna, Pawlik, Katarzyna, Mika, Joanna, Waszkielewicz, Anna M.

“…A series of 10 aminoalkanol derivatives of 5‐chloro‐2‐ or 5‐chloro‐4‐methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test,…”
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Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders-A Review of Structure-Activity Relationships by Gunia-Krzyżak, Agnieszka, Pańczyk, Katarzyna, Waszkielewicz, Anna M., Marona, Henryk

“…The cinnamamide scaffold has been incorporated in to the structure of numerous organic compounds with therapeutic potential. The scaffold enables multiple…”
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HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling by Pytka, Karolina, Głuch-Lutwin, Monika, Żmudzka, Elżbieta, Sałaciak, Kinga, Siwek, Agata, Niemczyk, Katarzyna, Walczak, Maria, Smolik, Magdalena, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Filipek, Barbara, Sapa, Jacek, Kołaczkowski, Marcin, Pańczyk, Katarzyna, Waszkielewicz, Anna, Marona, Henryk

“…Numerous studies have proven that both stimulation and blockade of 5-HT 1A and the blockade of 5-HT 7 receptors might cause the anxiolytic-like effects. Biased…”
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Sirtuins as a potential molecular target of cosmetic ingredients by Brezdeń, Katarzyna, Pańczyk-Straszak, Katarzyna, Waszkielewicz, Anna

“…Sirtuins are a group of enzymes belonging to histone deacetylases. However, they can also catalyze other deacylation reactions (including, for example,…”
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Xanthone Derivatives in the Fight against Glioblastoma and Other Cancers by Mazur, Gabriela, Pańczyk-Straszak, Katarzyna, Waszkielewicz, Anna Maria

“…Xanthone derivatives constitute an interesting and widely studied group of compounds, both in terms of the activity of naturally occurring plant ingredients…”
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KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain by Waszkielewicz, Anna, Marona, Henryk, Pańczyk-Straszak, Katarzyna, Filipek, Barbara, Rapacz, Anna, Sałat, Kinga, Kubacka, Monika, Cios, Agnieszka, Fedak, Filip, Walczak, Maria, Hubicka, Urszula, Kwiecień, Anna, Żuromska-Witek, Barbara, Szafrański, Przemysław W, Koczurkiewicz-Adamczyk, Paulina, Pękala, Elżbieta, Przejczowska-Pomierny, Katarzyna, Pociecha, Krzysztof, Wyska, Elżbieta

“…Epilepsy frequently coexists with neuropathic pain. Our approach is based on the search for active compounds with multitarget profiles beneficial in terms of…”
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Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands by Panczyk, Katarzyna, Golda, Sylwia, Waszkielewicz, Anna, Zelaszczyk, Dorota, Gunia-Krzyzak, Agnieszka, Marona, Henryk

“…The serotonergic system is involved in pathomechanisms of both epilepsy and neuropathic pain. So far, participation in the epileptogenesis and maintenance of…”
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Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system by Żelaszczyk, Dorota, Jakubczyk, Magdalena, Pytka, Karolina, Rapacz, Anna, Walczak, Maria, Janiszewska, Paulina, Pańczyk, Katarzyna, Żmudzki, Paweł, Słoczyńska, Karolina, Marona, Henryk, Waszkielewicz, Anna M.

“…[Display omitted] Searching for CNS active cyclic amines derivatives containing heterocyclic xanthone core we designed and synthesized a set of fourteen novel…”
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Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3 by Gunia-Krzyżak, Agnieszka, Żelaszczyk, Dorota, Rapacz, Anna, Żesławska, Ewa, Waszkielewicz, Anna M., Pańczyk, Katarzyna, Słoczyńska, Karolina, Pękala, Elżbieta, Nitek, Wojciech, Filipek, Barbara, Marona, Henryk

“…[Display omitted] •(E)-N-cinnamoyl derivatives of aminoalkanols were tested in rodents.•Maximal electroshock, subcutaneous pentylenetetrazole and 6-Hz tests…”
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Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives by Pańczyk, Katarzyna, Rapacz, Anna, Furgała-Wojas, Anna, Sałat, Kinga, Koczurkiewicz-Adamczyk, Paulina, Łucjanek, Martyna, Skiba-Kurek, Iwona, Karczewska, Elżbieta, Sowa, Aleksandra, Żelaszczyk, Dorota, Siwek, Agata, Popiół, Justyna, Pękala, Elżbieta, Marona, Henryk, Waszkielewicz, Anna

“…[Display omitted] As part of the presented research, thirteen new aminoalkanol derivatives were designed and obtained by chemical synthesis. In vivo studies…”
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Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems by Waszkielewicz, Anna Maria, Kubacka, Monika, Pańczyk, Katarzyna, Mogilski, Szczepan, Siwek, Agata, Głuch-Lutwin, Monika, Gryboś, Anna, Filipek, Barbara

“…New phenylpiperazine derivatives were synthesized and evaluated for binding to adrenergic receptors, α1-adrenolytic properties in vitro and hypotensive…”
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Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains by Klesiewicz, Karolina, Karczewska, Elżbieta, Nowak, Paweł, Skiba-Kurek, Iwona, Sito, Edward, Pańczyk, Katarzyna, Koczurkiewicz, Paulina, Żelaszczyk, Dorota, Pękala, Elżbieta, Waszkielewicz, Anna M., Budak, Alicja, Marona, Henryk, Gunia-Krzyżak, Agnieszka

“…In this study, thirty-five N -substituted derivatives of cinnamic acid amide (cinnamamide) were evaluated for anti- Helicobacter pylori activity using an agar…”
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In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4-substituted 1-(2-methoxyphenyl)piperazine derivatives by Słoczyńska, Karolina, Pańczyk, Katarzyna, Waszkielewicz, Anna M., Marona, Henryk, Pękala, Elżbieta

“…In vitro mutagenic, antimutagenic, and antioxidant potency evaluation and biotransformation of six novel 4‐substituted 1‐(2‐methoxyphenyl)piperazine…”
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Design, Synthesis and Anticonvulsant Activity of New Phenoxyalkyl, Phenoxyethoxyethyl and Phenoxyacetyl Derivatives of Aminoalkanols by Pańczyk‐Straszak, Katarzyna, Rapacz, Anna, Marona, Henryk, Żelaszczyk, Dorota, Karczewska, Elżbieta, Zając, Martyna, Skiba‐Kurek, Iwona, Siwek, Agata, Waszkielewicz, Anna

“…Forty new aminoalkanol derivatives with potential anticonvulsant activity were designed and synthesized. In vivo studies (mice, intraperitoneal administration)…”
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Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids by Pańczyk, Katarzyna, Żelaszczyk, Dorota, Koczurkiewicz, Paulina, Słoczyńska, Karolina, Pękala, Elżbieta, Żesławska, Ewa, Nitek, Wojciech, Żmudzki, Paweł, Marona, Henryk, Waszkielewicz, Anna

“…A series of 17 new phenoxyacetamides has been prepared multistep chemical synthesis as a continuation of the research carried out by our group on di- and…”
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Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system by Pańczyk, Katarzyna, Pytka, Karolina, Jakubczyk, Magdalena, Rapacz, Anna, Sałat, Kinga, Furgała, Anna, Siwek, Agata, Głuch-Lutwin, Monika, Gryboś, Anna, Słoczyńska, Karolina, Pękala, Elżbieta, Żmudzki, Paweł, Bucki, Adam, Kołaczkowski, Marcin, Żelaszczyk, Dorota, Marona, Henryk, Waszkielewicz, Anna M.

“…[Display omitted] •Presented compounds possess mainly antagonistic activity for serotonergic receptors.•Compound 9 showed 5-HT1A Ki = 5 nM, 5-HT7 Ki = 70 nM,…”
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Design, synthesis and anticonvulsant-analgesic activity of new N -[(phenoxy)alkyl]- and N -[(phenoxy)ethoxyethyl]aminoalkanols by Rapacz, Anna, Waszkielewicz, Anna M, Pańczyk, Katarzyna, Pytka, Karolina, Koczurkiewicz, Paulina, Piska, Kamil, Pękala, Elżbieta, Budziszewska, Bogusława, Starek-Świechowicz, Beata, Marona, Henryk

“…New derivatives of -[(phenoxy)alkyl]- and -[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal…”
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Novel xanthone derivatives as potent sirtuin 2 inhibitors by Mazur, Gabriela, Pańczyk-Straszak, Katarzyna, Krysińska, Karolina, Niemiec, Karolina, Waszkielewicz, Anna

“…[Display omitted] Six amino derivatives of xanthone were obtained via chemical synthesis. Biochemical studies revealed their SIRT2 inhibitory activity ranging…”
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Synthesis of N‐(phenoxyalkyl)‐, N‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System by Pańczyk, Katarzyna, Pytka, Karolina, Jakubczyk, Magdalena, Rapacz, Anna, Siwek, Agata, Głuch‐Lutwin, Monika, Gryboś, Anna, Słoczyńska, Karolina, Koczurkiewicz, Paulina, Ryszawy, Damian, Pękala, Elżbieta, Budziszewska, Bogusława, Starek‐Świechowicz, Beata, Suraj‐Prażmowska, Joanna, Walczak, Maria, Żesławska, Ewa, Nitek, Wojciech, Bucki, Adam, Kołaczkowski, Marcin, Żelaszczyk, Dorota, Francik, Renata, Marona, Henryk, Waszkielewicz, Anna M.

“…Depression, anxiety and epilepsy share some etiology factors, causing frequently observed multimodal activity of centrally active compounds. This might raise…”
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