Search Results - "PYRHONEN, Seppo"

Phase III Trial of Cetuximab With Continuous or Intermittent Fluorouracil, Leucovorin, and Oxaliplatin (Nordic FLOX) Versus FLOX Alone in First-Line Treatment of Metastatic Colorectal Cancer: The NORDIC-VII Study by MAGNE TVEIT, Kjell, GUREN, Tormod, FOKSTUEN, Tone, HANSEN, Flemming, HOFSLI, Eva, BIRKEMEYER, Elke, JOHNSSON, Anders, STARKHAMMAR, Hans, YILMAZ, Mette Karen, KELDSEN, Nina, BERIT ERDAL, Anne, DAJANI, Olav, GLIMELIUS, Bengt, DAHL, Olav, CHRISTOFFERSEN, Thoralf, PFEIFFER, Per, SORBYE, Halfdan, PYRHONEN, Seppo, SIGURDSSON, Fridbjorn, KURE, Elin, IKDAHL, Tone, SKOVLUND, Eva

“…The NORDIC-VII multicenter phase III trial investigated the efficacy of cetuximab when added to bolus fluorouracil/folinic acid and oxaliplatin (Nordic FLOX),…”
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Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer by Elzagheid, Adam, MD, PhD, Korkeila, Eija, MD, PhD, Bendardaf, Riyad, MD, PhD, Buhmeida, Abdelbaset, MD, PhD, Heikkilä, Suvi, MD, PhD, Vaheri, Antti, MD, PhD, Syrjänen, Kari, MD, PhD, Pyrhönen, Seppo, MD, PhD, Carpén, Olli, MD, PhD

“…Summary Ezrin is a membrane-cytoskeleton anchor, which, in experimental models, regulates tumor cell invasion and metastatic ability. We carried out…”
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Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: a single-group phase 2 trial by Eisen, Tim, Prof, Joensuu, Heikki, Prof, Nathan, Paul D, PhD, Harper, Peter G, FRCP, Wojtukiewicz, Marek Z, Prof, Nicholson, Steve, MD, Bahl, Amit, MD, Tomczak, Piotr, PhD, Pyrhonen, Seppo, Prof, Fife, Kate, MD, Bono, Petri, PhD, Boxall, Jane, RN, Wagner, Andrea, MD, Jeffers, Michael, PhD, Lin, Tiffany, PharmD, Quinn, David I, FRACP

“…Summary Background Regorafenib inhibits VEGF receptors 1, 2, and 3 and PDGF receptors like other anti-angiogenic tyrosine-kinase inhibitors approved for…”
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Loss of E-cadherin expression predicts disease recurrence and shorter survival in colorectal carcinoma by ELZAGHEID, ADAM, BUHMEIDA, ABDELBASET, LAATO, MATTI, EL-FAITORI, OMRAN, SYRJÄNEN, KARI, COLLAN, YRJÖ, PYRHÖNEN, SEPPO

“…Elzagheid A, Buhmeida A, Laato M, El‐Faitori O, Syrjänen K, Collan Y, Pyrhönen S. Loss of E‐cadherin expression predicts disease recurrence and shorter…”
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Melanoma-associated cancer-testis antigen 16 (CT16) regulates the expression of apoptotic and antiapoptotic genes and promotes cell survival by Nylund, Camilla, Rappu, Pekka, Pakula, Eveliina, Heino, Aleksi, Laato, Laura, Elo, Laura L, Vihinen, Pia, Pyrhönen, Seppo, Owen, Gethin R, Larjava, Hannu, Kallajoki, Markku, Heino, Jyrki

“…Cancer-testis (CT) antigens are predominantly expressed in testis or placenta, but absent in most adult tissues. During malignant transformation CT genes are…”
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Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer by Cunningham, David, Pyrhönen, Seppo, James, Roger D, Punt, Cornelis JA, Hickish, Tamas F, Heikkila, Reino, Johannesen, Tom B, Starkhammar, Hans, Topham, Clare A, Awad, Lucile, Jacques, Christian, Herait, Patrice

“…In phase II studies, irinotecan is active in metastatic colorectal cancer, but the overall benefit has not been assessed in a randomised clinical trial…”
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Prognostic Evaluation of COX-2 Expression in Renal Cell Carcinoma by KANKURI-TAMMILEHTO, Minna K, SÖDERSTRÖM, Karl-Ove, PELLINIEMI, Tarja-Terttu, VAHLBERG, Tero, PYRHÖNEN, Seppo O, SALMINEN, Eeva K

“…Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at…”
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E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome by Elzagheid, Adam, Algars, Annika, Bendardaf, Riyad, Lamlum, Hanan, Ristamaki, Raija, Collan, Yrjo, Syrjanen, Kari, Pyrhonen, Seppo

“…AIM： To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer. METHODS： E-cadherin expression was…”
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Benefit of adjuvant interferon alfa-2b (IFN-α) therapy in melanoma patients with high serum MMP-8 levels by Vihinen, Pia, Tervahartiala, Taina, Sorsa, Timo, Hansson, Johan, Bastholt, Lars, Aamdal, Steinar, Stierner, Ulrika, Pyrhönen, Seppo, Syrjänen, Kari, Lundin, Johan, Hernberg, Micaela

“…Matrix metalloproteinases (MMPs) are important enzymes in tissue turnover and various inflammatory processes. In this study, it was evaluated whether serum…”
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Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence by Avoranta, Suvi Tuulia

“…AIM： To investigate the prognostic value of CD44 variant 6 （CD44v6）, a membranous adhesion molecule, in rectal cancer. METHODS： Altogether, 210 rectal cancer…”
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Serum angiogenin levels predict treatment response in patients with stage IV melanoma by Vihinen, Pia, Kallioinen, Minna, Vuoristo, Meri-Sisko, Ivaska, Johanna, Syrjänen, Kari J, Hahka-Kemppinen, Marjo, Kellokumpu-Lehtinen, Pirkko-Liisa, Pyrhönen, Seppo O

“…This work was conducted to find out new potential serum markers and study their role as predictive factors in patients with metastatic melanoma. Serum samples…”
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Cytoplasmic E-Cadherin Expression Is Associated With Higher Tumour Level of VEGFA, Lower Response Rate to Irinotecan-based Treatment and Poorer Prognosis in Patients With Metastatic Colorectal Cancer by Bendardaf, Riyad, Sharif-Askari, Fatemeh Saheb, Sharif-Askari, Narjes Saheb, Syrjänen, Kari, Pyrhönen, Seppo

“…The prognostic value of vascular endothelial growth factor-A (VEGFA) and epithelial cadherin (E-cadherin) expression in patients with metastatic colorectal…”
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Long-term Survival of Stage IV Melanoma Patients Treated with BOLD Combination Chemotherapy and Intermediate-dose Subcutaneous Interferon-alpha by Mattila, Kalle, Raanta, Pirita, Lahtela, Valtteri, Pyrhönen, Seppo, Koskivuo, Ilkka, Vihinen, Pia

“…Immune checkpoint and serine/threonine-protein kinase inhibitors have become a standard of care for advanced cutaneous melanoma, but dacarbazine-based…”
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Diagnosis delay in Libyan female breast cancer by Ermiah, Eramah, Abdalla, Fathi, Buhmeida, Abdelbaset, Larbesh, Entesar, Pyrhönen, Seppo, Collan, Yrjö

“…To study the diagnosis delay and its impact on stage of disease among women with breast cancer on Libya. 200 women, aged 22 to 75 years with breast cancer…”
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Patients with hMLH1 or/and hMSH2-deficient Metastatic Colorectal Cancer Are Associated with Reduced Levels of Vascular Endothelial Growth Factor-1 Expression and Higher Response Rate to Irinotecan-based Regimen by Bendardaf, Riyad, Sharif-Askari, Fatemeh Saheb, Sharif-Askari, Narjes Saheb, Syrjänen, Kari, Pyrhönen, Seppo

“…The benefit of IFL (irinotecan, fluorouracil and leucovorin) regimen for metastatic colorectal cancer patients (mCRCs) with high levels of microsatellite…”
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High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer by Elzagheid, Adam, Emaetig, Fatma, Alkikhia, Lamia, Buhmeida, Abdelbaset, Syrjänen, Kari, El-Faitori, Omran, Latto, Matti, Collan, Yrjö, Pyrhönen, Seppo

“…Despite compelling evidence from the genetic background and clinical studies indicating that cyclooxygenase-2 (COX2) up-regulation is a key step in…”
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High Serum Levels of Matrix Metalloproteinase-9 and Matrix Metalloproteinase-1 Are Associated with Rapid Progression in Patients with Metastatic Melanoma by Nikkola, Johanna, Vihinen, Pia, Vuoristo, Meri-Sisko, Kellokumpu-Lehtinen, Pirkko, Kähäri, Veli-Matti, Pyrhönen, Seppo

“…Purpose: Matrix metalloproteinases (MMP) are proteolytic enzymes that play an important role in various aspects of cancer progression. In the present work, we…”
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The effect of vascular endothelial growth factor-1 expression on survival of advanced colorectal cancer patients by Bendardaf, Riyad, El-Serafi, Ahmed, Syrjänen, Kari, Collan, Yrjö, Pyrhönen, Seppo

“…Colorectal cancer is third leading cause of cancer mortality. About 60% of patients had already developed metastasis at the time of diagnosis. Vascular…”
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Psychosocial outcomes of e-feedback of radiotherapy for breast cancer patients: a randomized controlled trial by Siekkinen, Mervi, Pyrhönen, Seppo, Ryhänen, Anne, Vahlberg, Tero, Leino-Kilpi, Helena

“…Objective This study aims to test the effectiveness on psychosocial outcomes of electronic feedback knowledge of radiotherapy intervention (e‐Re‐Know) for…”
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ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer by Avoranta, S. Tuulia, Korkeila, Eija A, Ristamäki, Raija H, Syrjänen, Kari J, Carpén, Olli M, Pyrhönen, Seppo O, Sundström, Jari T.T

“…Summary The cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) associates with treatment resistance and adverse outcome in several human cancers. We…”
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