Search Results - "PUZNIAK, Laura A"

Epidemiology and outcomes of culture-positive bloodstream pathogens prior to and during the SARS-CoV-2 pandemic: a multicenter evaluation by Bauer, Karri A, Puzniak, Laura A, Yu, Kalvin C, Finelli, Lyn, Moise, Pamela, Ai, ChinEn, Watts, Janet A, Gupta, Vikas

“…Bloodstream infections (BSIs) are an important cause of morbidity and mortality in hospitalized patients. We evaluate incidence of community- and…”
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Descriptive epidemiology of hospitalized patients with bacterial nosocomial pneumonia who experience 30-day readmission in the US, 2014-2019 by Zilberberg, Marya D, Nathanson, Brian H, Puzniak, Laura A, Zilberberg, Noah W D, Shorr, Andrew F

“…Nosocomial pneumonia (NP) remains associated with excess morbidity and mortality. The effect of NP on measures such as re-admission at 30 days remains unclear…”
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Association of SARS-CoV-2 status and antibiotic-resistant bacteria with inadequate empiric therapy in hospitalized patients: a US multicenter cohort evaluation (July 2019 - October 2021) by Bauer, Karri A, Puzniak, Laura A, Yu, Kalvin C, Klinker, Kenneth P, Watts, Janet A, Moise, Pamela A, Finelli, Lyn, Gupta, Vikas

“…Antibiotic usage and antibiotic resistance (ABR) patterns changed during the COVID-19 pandemic. Inadequate empiric antibiotic therapy (IET) is a significant…”
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The risk of inappropriate empiric treatment and its outcomes based on pathogens in non-ventilated (nvHABP), ventilated (vHABP) hospital-acquired and ventilator-associated (VABP) bacterial pneumonia in the US, 2012–2019 by Zilberberg, Marya D., Nathanson, Brian H., Puzniak, Laura A., Dillon, Ryan J., Shorr, Andrew F.

“…Background Inappropriate empiric antimicrobial treatment (IET) contributes to worsened outcomes. While IET’s differential impact across types of nosocomial…”
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A multicenter evaluation of antibacterial use in hospitalized patients through the SARS-Cov-2 pandemic waves by Puzniak, Laura A, Bauer, Karri A, Yu, Kalvin C, Watts, Janet A, Ai, ChinEn, Gupta, Vikas

“…Excessive use of antibiotics has been reported during the SARS-CoV-2 pandemic. We evaluated trends in antibiotic use and culture positive Gram-negative…”
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Proportion of Patients in the United States Who Fill Their Nirmatrelvir/Ritonavir Prescriptions by Rudolph, Abby E., Khan, Farid L., Singh, Tanya G., Valluri, Srinivas Rao, Puzniak, Laura A., McLaughlin, John M.

“…Introduction Although real-world studies demonstrate that those prescribed nirmatrelvir/ritonavir (and particularly within 5 days of symptom onset) are less…”
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Healthcare Resource Utilization of Ceftolozane/Tazobactam Versus Meropenem for Ventilated Nosocomial Pneumonia from the Randomized, Controlled, Double-Blind ASPECT-NP Trial by Lodise, Thomas, Yang, Joe, Puzniak, Laura A., Dillon, Ryan, Kollef, Marin

“…Introduction Hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP) are associated with significant healthcare resource utilization…”
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Predictors of Clinical Success in the Treatment of Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Nosocomial Pneumonia (NP) by Shorr, Andrew F, Puzniak, Laura A, Biswas, Pinaki, Niederman, Michael S

“…Methicillin-resistant Staphylococcus aureus (MRSA) remains an important pathogen in nosocomial pneumonia and is associated with significant morbidity and…”
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Retrospective Real-World Evaluation of Outcomes in Patients with Skin and Soft Structure Infections Treated with Tedizolid in an Outpatient Setting by Kullar, Ravina, Puzniak, Laura A., Swindle, Jason P., Lodise, Thomas

“…Introduction Outcomes data for patients who received tedizolid for acute bacterial skin and skin-structure infections (ABSSSIs) are scant. We provide a…”
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Inappropriate Empiric Therapy Impacts Complications and Hospital Resource Utilization Differentially Among Different Types of Bacterial Nosocomial Pneumonia: A Cohort Study, United States, 2014-2019 by Zilberberg, Marya D, Nathanson, Brian H, Puzniak, Laura A, Zilberberg, Noah W D, Shorr, Andrew F

“…Nosocomial pneumonia (NP) remains a costly complication of hospitalization fraught with subsequent complications and augmented resource utilization. Consisting…”
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Assessing Rates of Co-Resistance and Patient Outcomes in Multidrug-Resistant Pseudomonas aeruginosa by Appaneal, Haley J, Caffrey, Aisling R, Lopes, Vrishali, Piehl, Emily C, Puzniak, Laura A, LaPlante, Kerry L

“…Multidrug-resistant (MDR) Pseudomonas aeruginosa infections are associated with poor patient outcomes due to complex co-resistance patterns. We described…”
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Clostridium difficile in the Intensive Care Unit: Epidemiology, Costs, and Colonization Pressure by Lawrence, Steven J., Puzniak, Laura A., Shadel, Brooke N., Gillespie, Kathleen N., Kollef, Marin H., Mundy, Linda M.

“…To evaluate the epidemiology, outcomes, and importance of Clostridium difficile colonization pressure (CCP) as a risk factor for C. difficile-associated…”
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Treatment Heterogeneity in Pseudomonas aeruginosa Pneumonia by Caffrey, Aisling R., Appaneal, Haley J., Liao, J. Xin, Piehl, Emily C., Lopes, Vrishali, Puzniak, Laura A.

“…We have previously identified substantial antibiotic treatment heterogeneity, even among organism-specific and site-specific infections with treatment…”
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The Comparative Effectiveness of Ceftolozane/Tazobactam versus Aminoglycoside- or Polymyxin-Based Regimens in Multi-Drug-Resistant Pseudomonas aeruginosa Infections by Caffrey, Aisling R, Appaneal, Haley J, Liao, J Xin, Piehl, Emily C, Lopes, Vrishali, Dillon, Ryan J, Puzniak, Laura A, LaPlante, Kerry L

“…Pseudomonas aeruginosa infections are challenging to treat due to multi-drug resistance (MDR) and the complexity of the patients affected by these serious…”
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Impact of patient characteristics and infection type on clinical outcomes of patients who received linezolid or vancomycin for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus : a pooled data analysis by Puzniak, Laura A, Capitano, Blair, Biswas, Pinaki, Lodise, Thomas P

“…Abstract Phase III randomized, clinical trials are primarily designed to evaluate overall treatment-outcome comparisons. Although valuable data are gained from…”
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Impact of Weight on Treatment Efficacy and Safety in Complicated Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus by Puzniak, Laura A., PhD, MPH, Morrow, Lee E., MD, Huang, David B., MD, PhD, Barreto, Jason N., PharmD

“…Abstract Background There are few data on dose optimization and clinical outcomes of antimicrobial agents based on patients’ weight, despite the rising…”
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Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas aeruginosa by Pogue, Jason M, Kaye, Keith S, Veve, Michael P, Patel, Twisha S, Gerlach, Anthony T, Davis, Susan L, Puzniak, Laura A, File, Tom M, Olson, Shannon, Dhar, Sorabh, Bonomo, Robert A, Perez, Federico

“…Abstract Background Ceftolozane/tazobactam is a novel cephalosporin/beta-lactamase inhibitor combination that often retains activity against resistant…”
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Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020 by Finelli, Lyn, Gupta, Vikas, Petigara, Tanaz, Yu, Kalvin, Bauer, Karri A, Puzniak, Laura A

“…Mortality is an important measure of the severity of a pandemic. This study aimed to understand how mortality by age of hospitalized patients who were tested…”
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Descriptive Epidemiology and Outcomes of Nonventilated Hospital-Acquired, Ventilated Hospital-Acquired, and Ventilator-Associated Bacterial Pneumonia in the United States, 2012–2019 by Zilberberg, Marya D., Nathanson, Brian H., Puzniak, Laura A., Shorr, Andrew F.

“…Multiple randomized controlled trials exploring the outcomes of patients with ventilator-associated bacterial pneumonia and hospital-acquired bacterial…”
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Predictors of Clinical Success Among a National Veterans Affairs Cohort With Methicillin-Resistant Staphylococcus aureus Pneumonia by Caffrey, Aisling R., PhD, MS, Morrill, Haley J., PharmD, Puzniak, Laura A., PhD, MPH, LaPlante, Kerry L., PharmD

“…Abstract Background The treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is exceedingly complicated, which is concerning because of…”
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