Search Results - "PURUSHOTHAM, A. D"

A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive by Pal, A., Provenzano, E., Duffy, S. W., Pinder, S. E., Purushotham, A. D.

“…Background: Women with axillary sentinel lymph node (SLN)‐positive breast cancer usually undergo completion axillary lymph node dissection (ALND). However, not…”
Get full text

Adjuvant taxanes and the development of breast cancer-related arm lymphoedema by Cariati, M., Bains, S. K., Grootendorst, M. R., Suyoi, A., Peters, A. M., Mortimer, P., Ellis, P., Harries, M., Van Hemelrijck, M., Purushotham, A. D.

“…Background Despite affecting approximately one‐quarter of all patients undergoing axillary lymph node dissection, the pathophysiology of breast cancer‐related…”
Get full text

Neoadjuvant chemotherapy in breast cancer by Charfare, H., Limongelli, S., Purushotham, A. D.

“…Background: Neoadjuvant chemotherapy for breast cancer was originally used in locally advanced inoperable disease in order to achieve surgical resection. It…”
Get full text

Screen-detected vs symptomatic breast cancer: is improved survival due to stage migration alone? by Wishart, G C, Greenberg, D C, Britton, P D, Chou, P, Brown, C H, Purushotham, A D, Duffy, S W

“…This paper examines whether screen-detected breast cancer confers additional prognostic benefit to the patient, over and above that expected by any shift in…”
Get full text

Cancer risk and prevention in a globalised world: Solving the public policy mismatch by Sullivan, R, Homberg, L, Purushotham, A.D

“…Abstract The world faces an unprecedented growth in cancer incidence over the next fifty years, the majority of the burden falling on low-middle income…”
Get full text

Stem cells and breast cancer by Cariati, M, Purushotham, A D

“…Proliferation in continuously renewing tissues, including the mammary gland, is hierarchically organized with a small number of slowly dividing stem cells and…”
Get full text

Immediate breast reconstruction after mastectomy for cancer by Malata, C. M., McIntosh, S. A., Purushotham, A. D.

“…Background Immediate breast reconstruction after mastectomy has increased over the past decade following the unequivocal demonstration of its oncological…”
Get full text

Darwin, medicine and cancer by Purushotham, A.D., Sullivan, R.

“…‘Nothing in biology makes sense except in the light of evolution’! So said Theodore Dobzhansky. It is extraordinary how little Darwinism and post-Darwinian…”
Get full text

When is a completion axillary lymph node dissection necessary in the presence of a positive sentinel lymph node? by Suyoi, A, Bains, S.K, Kothari, A, Douek, M, Agbaje, O, Hamed, H, Fentiman, I, Pinder, S, Purushotham, A.D

“…Abstract Background The management of the axilla in the presence of positive sentinel lymph node (SLN) remains controversial. Many centres forgo completion…”
Get full text

The value of immunohistochemistry in sentinel lymph node histopathology in breast cancer by KLEVESATH, M. B, BOBROW, L. G, PINDER, S. E, PURUSHOTHAM, A. D

“…The optimal protocol for the histopathological examination of sentinel lymph nodes (SLNs) in breast cancer has not been determined. The value of more detailed…”
Get full text

An analysis of research activity in major UK cancer centres by Sullivan, R, Lewison, G, Purushotham, A.D

“…Abstract The organisation of cancer research is critical to its overall creativity and productivity. Cancer centres are a major organisational structure for…”
Get full text

Treatment and survival in breast cancer in the Eastern Region of England by Wishart, G.C., Greenberg, D.C., Chou, P., Brown, C.H., Duffy, S., Purushotham, A.D.

“…The reasons for variation in survival in breast cancer are multifactorial. From 1999 to 2003, the vital status of 9051 cases of invasive breast cancer was…”
Get full text

Lymphoedema following surgery for breast cancer by Pain, S. J., Purushotham, A. D.

“…Background Lymphoedema is a common complication of breast cancer treatment, affecting approximately a quarter of patients. Those affected can have an…”
Get full text

Can breast MRI help in the management of women with breast cancer treated by neoadjuvant chemotherapy? by WARREN, R. M. L, BOBROW, L. G, EARL, H. M, BRITTON, P. D, GOPALAN, D, PURUSHOTHAM, A. D, WISHART, G. C, BENSON, Jr, HOLLINGWORTH, W

“…Contrast-enhanced (CE) MRI was used to monitor breast cancer response to neoadjuvant chemotherapy. Patients underwent CE MRI before and after therapy, together…”
Get full text

Randomized clinical trial of no wound drains and early discharge in the treatment of women with breast cancer by Purushotham, A. D., McLatchie, E., Young, D., George, W. D., Stallard, S., Doughty, J., Brown, D. C., Farish, C., Walker, A., Millar, K., Murray, G.

“…Background: Women undergoing surgery for primary breast cancer routinely have suction drains inserted deep to the wounds, which are removed approximately 6–8…”
Get full text

Axillary vein abnormalities contribute to development of lymphoedema after surgery for breast cancer by Pain, S. J., Vowler, S., Purushotham, A. D.

“…Background: The aetiology of breast cancer‐related lymphoedema (BCRL) is poorly understood and multifactorial. Previous work has suggested that acquired…”
Get full text

Pregnancy after breast cancer by Upponi, S.S, Ahmad, F, Whitaker, I.S, Purushotham, A.D

“…The issue of pregnancy in patients previously treated for breast cancer is controversial. This paper reviews the literature using Medline and Embase databases…”
Get full text

Meta-analysis of superficial versus deep injection of radioactive tracer and blue dye for lymphatic mapping and detection of sentinel lymph nodes in breast cancer by Ahmed, M., Purushotham, A. D., Horgan, K., Klaase, J. M., Douek, M.

“…Background Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging in early breast cancer. Currently, no consensus exists on the optimal…”
Get full text

Sympathetic nerve damage as a potential cause of lymphoedema after axillary dissection for breast cancer by Bennett Britton, T. M., Wallace, S. M. L., Wilkinson, I. B., Mortimer, P. S., Peters, A. M., Purushotham, A. D.

“…Background: The physiological disturbances leading to lymphoedema after breast cancer surgery are poorly understood. Damage to sympathetic nerves during…”
Get full text

Bone marrow micrometastasis in breast cancer by Ozbas, S., Dafydd, H., Purushotham, A. D.

“…Background: Several studies have demonstrated that bone marrow micrometastasis in patients with breast cancer is an independent prognostic factor for systemic…”
Get full text