Search Results - "PURNAPATRE, Kedar"

In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens by Purnapatre, Kedar P, Rao, Madhvi, Pandya, Manisha, Khanna, Alka, Chaira, Tridib, Bambal, Ramesh, Upadhyay, Dilip J, Masuda, Nobuhisa

“…The emergence of multidrug-resistant (MDR) Gram-negative bacilli is a major concern in the treatment of nosocomial infections. Antibacterial agents with novel…”
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DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa by Kumar, Manoj, Rao, Madhvi, Purnapatre, Kedar P, Barman, Tarani Kanta, Joshi, Vattan, Kashyap, Amuliya, Chaira, Tridib, Bambal, Ramesh B, Pandya, Manisha, Khodor, Souhaila Al, Upadhyay, Dilip J, Masuda, Nobuhisa

“…DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum…”
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Identification and synthesis of novel inhibitors of mycobacterium ATP synthase by Surase, Yogesh B., Samby, Kirandeep, Amale, Sagar R., Sood, Ruchi, Purnapatre, Kedar P., Pareek, Pawan K., Das, Biswajit, Nanda, Kamna, Kumar, Subodh, Verma, Ashwani K.

“…Novel series of non-DARQ (DiARyl Quinoline) template as ATP synthase inhibitor have been identified and scaffold hopping approach led to compound 14b, with…”
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Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast by Honigberg, Saul M, Purnapatre, Kedar

“…Diploid yeast, like most eukaryotes, can undergo meiotic differentiation to form haploid gametes. Meiotic differentiation and cell growth (proliferation) are…”
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Mode of Action of Ranbezolid against Staphylococci and Structural Modeling Studies of Its Interaction with Ribosomes by KALIA, Vandana, MIGLANI, Rajni, RAI, V. Samuel, PURNAPATRE, Kedar P, MATHUR, Tarun, SINGHAL, Smita, KHAN, Seema, VOLETI, Sreedhara R, UPADHYAY, Dilip J, KULVINDER SINGH SAINI, RATTAN, Ashok

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Ciprofloxacin-resistant Neisseria meningitidis, Delhi, India by Singhal, Smita, Purnapatre, Kedar P, Kalia, Vandana, Dube, Smita, Nair, Deepti, Deb, Monorama, Aggarwal, Pushpa, Gupta, Sunil, Upadhyay, Dilip J, Rattan, Ashok, Raj, V Samuel

“…Decreased susceptibility of Neisseria meningitidis isolates to ciprofloxacin emerged from an outbreak in Delhi, India. Results of antimicrobial susceptibility…”
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Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase by Gray, Misa, Piccirillo, Sarah, Purnapatre, Kedar, Schneider, Brandt L, Honigberg, Saul M

“…Several components of the glucose induction pathway, namely the Snf3p glucose sensor and the Rgt1p and Mth1p transcription factors, were shown to be involved…”
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Glucose Inhibits Meiotic DNA Replication through SCFGrr1p-Dependent Destruction of Ime2p Kinase by Purnapatre, Kedar, Gray, Misa, Piccirillo, Sarah, Honigberg, Saul M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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UDP-N-acetylglucosamine enolpyruvyl transferase from Pseudomonas aeruginosa by Dube, Smita, Nanda, Kamna, Rani, Reema, Kaur, Namrata Jit, Nagpal, Jatin Kumar, Upadhyay, Dilip J, Cliffe, Ian A, Saini, Kulvinder Singh, Purnapatre, Kedar P

“…Multi-drug resistant Pseudomonas aeruginosa (MDRPA) are emerging as a major threat in the hospitals as they have become resistant to current antibiotics. There…”
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The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae by Purnapatre, Kedar, Piccirillo, Sarah, Schneider, Brandt L, Honigberg, Saul M

“…Background: IME1, which is required for the initiation of meiosis, is regulated by Cln3:Cdc28 kinase, which activates the G1‐to‐S transition, and Snf1 kinase,…”
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Cell Size and Cln-Cdc28 Complexes Mediate Entry into Meiosis by Modulating Cell Growth by Day, Audra, Markwardt, Jody, Delaguila, Rolando, Zhang, Jian, Purnapatre, Kedar, Honigberg, Saul M., Schneider, Brandt L.

“…In the yeast Saccharomyces cerevisiae, mitotic cell cycle progression depends upon the G1-phase cyclin-dependent kinase Cln-Cdc28 and cell growth to a minimum…”
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Differential effects of single-stranded DNA binding proteins (SSBs) on uracil DNA glycosylases (UDGs) from Escherichia coli and mycobacteria by Purnapatre, Kedar, Handa, Priya, Venkatesh, Jeganathan, Varshney, Umesh

“…Deamination of cytosines results in accumulation of uracil residues in DNA, which unless repaired lead to GC→AT transition mutations. Uracil DNA glyco-sylase…”
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Distinct properties of Mycobacterium tuberculosis single-stranded DNA binding protein and its functional characterization in Escherichia coli by Handa, P, Acharya, N, Thanedar, S, Purnapatre, K, Varshney, U

“…Single-stranded DNA binding proteins (SSBs) play an essential role in various DNA functions. Characterization of SSB from Mycobacterium tuberculosis, which…”
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Cytochrome P450s in the development of target-based anticancer drugs by Purnapatre, Kedar, Khattar, Sunil K, Saini, Kulvinder Singh

“…Abstract Enzymes of the cytochrome P450 (CYP) superfamily are the major determinants of half-life and execute pharmacological effects of many therapeutic…”
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Ciprofloxacin-Resistant Neisseria meningitidis , Delhi, India by Singhal, Smita, Purnapatre, Kedar P., Kalia, Vandana, Dube, Smita, Nair, Deepti, Deb, Monorama, Aggarwal, Pushpa, Gupta, Sunil, Upadhyay, Dilip J., Rattan, Ashok, Raj, V. Samuel

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A Novel Ketolide, RBx 14255, with Activity against Multidrug-Resistant Streptococcus pneumoniae by SAMUEL RAJ, V, TARANI KANTA BARMAN, SURASE, Yogesh B, VENKATARAMANAN, R, CHAKRABARTI, Anjan, DAS, Biswajit, BHATNAGAR, Pradip K, KALIA, Vandana, PURNAPATRE, Kedar, DUBE, Smita, RAMKUMAR, G, BHATEJA, Pragya, MATHUR, Tarun, CHAIRA, Tridib, UPADHYAY, Dilip J

“…We present here the novel ketolide RBx 14255, a semisynthetic macrolide derivative obtained by the derivatization of clarithromycin, for its in vitro and in…”
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Characterisation of laboratory-generated vancomycin intermediate resistant Staphylococcus aureus strains by Bhateja, Pragya, Purnapatre, Kedar, Dube, Smita, Fatma, Tasneem, Rattan, Ashok

“…Vancomycin has been the drug of choice for 30 years for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). Emergence of decreased vancomycin…”
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Glucose Inhibits Meiotic DNA Replication through SCF super(Grr1p)-Dependent Destruction of Ime2p Kinase by Purnapatre, Kedar, Gray, Misa, Piccirillo, Sarah, Honigberg, Saul M

“…In the budding yeast Saccharomyces cerevisiae, the cell division cycle and sporulation are mutually exclusive cell fates; glucose, which stimulates the cell…”
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Use of sequence microdivergence in mycobacterial ortholog to analyze contributions of the water-activating loop histidine of Escherichia coli uracil–DNA glycosylase in reactant binding and catalysis by Acharya, Narottam, Talawar, Ramappa K, Purnapatre, Kedar, Varshney, Umesh

“…Uracil–DNA glycosylase (Ung), a DNA repair enzyme, pioneers uracil excision repair pathway. Structural determinations and mutational analyses of the Ung class…”
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Meiotic differentiation during colony maturation in Saccharomyces cerevisiae by Purnapatre, Kedar, Honigberg, Saul M

“…As yeast colonies ceased growth, cells at the edge of these colonies transited from the cell division cycle into meiosis at high efficiency. This transition…”
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