Search Results - "PURE, E"

Fibroblast activation protein in remodeling tissues by Jacob, M, Chang, L, Puré, E

“…Tissue remodeling is critical during development and wound healing. It also characterizes a number of pathologic conditions, including chronic inflammation,…”
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A crucial role for CD44 in inflammation by Puré, Ellen, Cuff, Carolyn A.

“…Current therapies for chronic inflammatory diseases typically act through the nonspecific downregulation of immune cell activation. However, it is becoming…”
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The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation by Cuff, C A, Kothapalli, D, Azonobi, I, Chun, S, Zhang, Y, Belkin, R, Yeh, C, Secreto, A, Assoian, R K, Rader, D J, Puré, E

“…Atherosclerosis causes most acute coronary syndromes and strokes. The pathogenesis of atherosclerosis includes recruitment of inflammatory cells to the vessel…”
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Abstract PL1: Stromal Cells and Matrix Remodeling as Essential Regulators of the Tumor Microenvironment by Pure, E

“…Carcinomas represent complex neo-organs in which extensive communication networks between surrounding non-transformed endothelial, neural, inflammatory and…”
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Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice by TANGIRALA, R. K, TSUKAMOTO, K, CHUN, S. H, USHER, D, PURE, E, RADER, D. J

“…The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of…”
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Induction of IL-12 and chemokines by hyaluronan requires adhesion- dependent priming of resident but not elicited macrophages by Hodge-Dufour, J, Noble, PW, Horton, MR, Bao, C, Wysoka, M, Burdick, MD, Strieter, RM, Trinchieri, G, Pure, E

“…Components of the extracellular matrix (ECM) can regulate leukocyte activation and function at inflammatory sites. Low molecular weight fragments of the ECM…”
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Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice by Detmers, Patricia A, Hernandez, Melba, Mudgett, John, Hassing, Heide, Burton, Charlotte, Mundt, Steven, Chun, Sam, Fletcher, Dan, Card, Deborah J, Lisnock, JeanMarie, Weikel, Renee, Bergstrom, James D, Shevell, Diane E, Hermanowski-Vosatka, Anne, Sparrow, Carl P, Chao, Yu-Sheng, Rader, Daniel J, Wright, Samuel D, Pure, Ellen

“…Inducible NO synthase (iNOS) present in human atherosclerotic plaques could contribute to the inflammatory process of plaque development. The role of iNOS in…”
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Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development by Rocca, B, Spain, L M, Puré, E, Langenbach, R, Patrono, C, FitzGerald, G A

“…Prostaglandin G and H synthases, or cyclooxygenases (COXs), catalyze the formation of prostaglandins (PGs). Whereas COX-1 is diffusely expressed in lymphoid…”
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Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages by Horton, M R, McKee, C M, Bao, C, Liao, F, Farber, J M, Hodge-DuFour, J, Puré, E, Oliver, B L, Wright, T M, Noble, P W

“…Hallmarks of chronic inflammation and tissue fibrosis are increased influx of activated inflammatory cells, mediator release, and increased turnover and…”
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Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E by Tangirala, Rajendra K., Praticó, Domenico, FitzGerald, Garret A., Chun, Sam, Tsukamoto, Kazuhisa, Maugeais, Cyrille, Usher, David C., Puré, Ellen, Rader, Daniel J.

“…Apolipoprotein E is a multifunctional protein synthesized by hepatocytes and macrophages. Plasma apoE is largely liver-derived and known to regulate…”
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Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth by Sretavan, D W, Feng, L, Puré, E, Reichardt, L F

“…The first retinal ganglion cell axons arriving at the embryonic mouse ventral diencephalon encounter an inverted V-shaped neuronal array defining the midline…”
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CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation by CAMP, R. L, SCHEYNIUS, A, JOHANSSON, C, PURE, E

“…The in vivo administration of certain monoclonal antibodies (mAbs) against the adhesion receptor, CD44, into normal mice induces both a modulation of CD44 from…”
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Rapid Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of ApoE in ApoE-Deficient Mice by Tsukamoto, Kazuhisa, Tangirala, Rajendra, Chun, Sam H, Puré, Ellen, Rader, Daniel J

“…Apolipoprotein E (apoE) is a multifunctional protein synthesized by the liver and tissue macrophages. ApoE-deficient mice have severe hyperlipidemia and…”
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A role for CD44 in the production of IFN-gamma and immunopathology during infection with Toxoplasma gondii by Blass, S L, Puré, E, Hunter, C A

“…The interaction of activated CD44 with its ligand, low m.w. hyaluronan, is involved in inflammation, but no role has been identified for this interaction in…”
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Inhibition of Interferon γ Induced Interleukin 12 Production: A Potential Mechanism for the Anti-Inflammatory Activities of Tumor Necrosis Factor by Hodge-Dufour, Jennifer, Marino, Michael W., Horton, Maureen R., Jungbluth, Achim, Burdick, Marie D., Strieter, Robert M., Noble, Paul W., Hunter, Christopher A., Pure, Ellen

“…Inflammation is associated with production of cytokines and chemokines that recruit and activate inflammatory cells. Interleukin (IL) 12 produced by…”
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Reduced contact sensitivity reactions in mice treated with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1 by Scheynius, A, Camp, RL, Pure, E

“…We have investigated the effect of the administration of mAb against leukocyte function-associated molecule-1 (CD11a/CD18) and intercellular adhesion…”
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T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis by LAZAAR, A. L, ALBELDA, S. M, PILEWSKI, J. M, BRENNAN, B, PURE, E, PANETTIERI, R. A

“…Asthma is a disease of airway inflammation and hyperreactivity that is associated with a lymphocytic infiltrate in the bronchial submucosa. The interactions…”
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CD40-Mediated Signal Transduction in Human Airway Smooth Muscle by Lazaar, Aili L, Amrani, Yassine, Hsu, Jason, Panettieri, Reynold A., Jr, Fanslow, William C, Albelda, Steven M, Pure, Ellen

“…CD40 is a member of the TNF receptor family that was initially described on the surface of B cells. Recently, CD40 has also been described on mesenchymal…”
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Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process by Noorchashm, Hooman, Bui, Anh, Li, Hsiu-Ling, Eaton, Ashlyn, Mandik-Nayak, Laura, Sokol, Carrie, Potts, Kathryn M., Puré, Ellen, Erikson, Jan

“…Anti-single stranded DNA (ssDNA) and anti-double stranded DNA (dsDNA) B cells are regulated in non-autoimmune mice. In this report we show that while both…”
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The Tyrosine Kinases Syk and Lyn Exert Opposing Effects on the Activation of Protein Kinase Akt/PKB in B Lymphocytes by Li, Hsiu-Ling, Davis, William W., Whiteman, Eileen L., Birnbaum, Morris J., Puré, Ellen

“…The protein kinase Akt/PKB is a crucial regulator of cell survival in response to mitogenic signals. The increased kinase activity of v-akt, an oncogenic form…”
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