Search Results - "PURDUE, P. E"

PEROXISOME BIOGENESIS by Purdue, P. Edward, Lazarow, Paul B

“…Fifteen years ago, we had a model of peroxisome biogenesis that involved growth and division of preexisting peroxisomes. Today, thanks to genetically tractable…”
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Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor by Purdue, P. Edward, Zhang, Jing Wei, Skoneczny, Marek, Lazarow, Paul B

“…The rhizomelic form of chondrodysplasia punctata (RCDP) is an autosomal recessive disease of peroxisome biogenesis characterized by deficiencies in several…”
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Targeting of Human Catalase to Peroxisomes Is Dependent upon a Novel COOH-Terminal Peroxisomal Targeting Sequence by Purdue, P. Edward, Lazarow, Paul B.

“…We have identified a novel peroxisomal targeting sequence (PTS) at the extreme COOH terminus of human catalase. The last four amino acids of this protein…”
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Mistargeting of Peroxisomal L-Alanine:Glyoxylate Aminotransferase to Mitochondria in Primary Hyperoxaluria Patients Depends Upon Activation of a Cryptic Mitochondrial Targeting Sequence by a Point Mutation by Purdue, P. E., Allsop, J., Isaya, G., Rosenberg, L. E., Danpure, C. J.

“…In approximately one-third of primary hyperoxaluria type 1 patients, disease is associated with a unique protein sorting defect in which hepatic…”
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Primary hyperoxaluria type 1: Genotypic and phenotypic heterogeneity by Danpure, C. J., Jennings, P. R., Fryer, P., Purdue, P. E., Allsop, J.

“…Summary Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disease caused by a deficiency of the liver‐specific peroxisomal enzyme alanine:…”
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Identification of Mutations Associated with Peroxisome-to-Mitochondrion Mistargeting of Alanine/Glyoxylate Aminotransferase in Primary Hyperoxaluria Type 1 by Purdue, P. Edward, Takada, Yoshikazu, Danpure, Christopher J.

“…We have previously shown that in some patients with primary hyperoxaluria type 1 (PH1), disease is associated with mistargeting of the normally peroxisomal…”
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Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation by DANPURE, C. J, PURDUE, P. E, DAVIDSON, N. O, FRYER, P, GRIFFITHS, S, ALLSOP, J, LUMB, M. J, GUTTRIDGE, K. M, JENNINGS, P. R, SCHEINMAN, J. I, MAUER, S. M

“…Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate…”
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Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon by Takada, Y, Kaneko, N, Esumi, H, Purdue, P E, Danpure, C J

“…The amino acid sequence of human hepatic peroxisomal L-alanine: glyoxylate aminotransferase 1 (AGTI) deduced from cDNA shows 78% sequence identity with that of…”
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The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase by Knott, T G, Birdsey, G M, Sinclair, K E, Gallagher, I M, Purdue, P E, Danpure, C J

“…Unlike most organellar proteins, some peroxisomal proteins are often found in significant amounts in the cytosol. Such apparent import inefficiency is very…”
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The role of cell-substrate interaction in regulating osteoclast activation: potential implications in targeting bone loss in rheumatoid arthritis by McHugh, K P, Shen, Z, Crotti, T N, Flannery, M R, O'Sullivan, R P, Purdue, P E, Goldring, S R

“…Analysis of tissues retrieved from the bone-pannus interface from patients with rheumatoid arthritis (RA) and studies in animal models of inflammatory…”
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Rhizomelic chondrodysplasia punctata, a peroxisomal biogenesis disorder caused by defects in Pex7p, a peroxisomal protein import receptor : A minireview by PURDUE, P. E, SKONECZNY, M, XUDONG YANG, ZHANG, J.-W, LAZAROW, P. B

“…Rhizomelic chondrodysplasia punctata (RCDP) is a lethal autosomal recessive disease corresponding to complementation group 11 (CG11), the second most common of…”
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Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase by Purdue, P E, Lumb, M J, Fox, M, Griffo, G, Hamon-Benais, C, Povey, S, Danpure, C J

“…We have previously reported the isolation of a genomic clone encoding human liver-specific peroxisomal alanine:glyoxylate aminotransferase (AGT, EC 2.6.1.44),…”
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Pex18p Is Constitutively Degraded during Peroxisome Biogenesis by Purdue, P. Edward, Lazarow, Paul B.

“…Pex18p and Pex21p are structurally related yeast peroxins (proteins required for peroxisome biogenesis) that are partially redundant in function. One or the…”
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Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway by Purdue, P.E. (Mount Sinai School of Medicine, New York, NY.), Yang, X, Lazarow, P.B

“…We have identified ScPex18p and ScPex21p, two novel S. cerevisiae peroxins required for protein targeting via the PTS2 branch of peroxisomal biogenesis…”
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A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1 by Purdue, P E, Lumb, M J, Allsop, J, Minatogawa, Y, Danpure, C J

“…We have synthesized and sequenced alanine:glyoxylate aminotransferase (AGT; HGMW-approved symbol for the gene--AGXT) cDNA from the liver of a primary…”
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Subcellular distribution of hepatic alanine:glyoxylate aminotransferase in various mammalian species by DANPURE, C. J, GUTTRIDGE, K. M, FRYER, P, JENNINGS, P. R, ALLSOP, J, PURDUE, P. E

“…The subcellular distribution of alanine:glyoxylate aminotransferase 1 (AGT1) enzyme activity and immunoreactive protein has been determined in the livers of a…”
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Nucleotide sequence of a cDNA encoding the beta subunit of the mitochondrial ATP synthase from Zea mays by WINNING, B. M, BATHGATE, B, PURDUE, P. E, LEAVER, C. J

“…The beta subunit of the mitochondrial F sub(1)-F sub(0) ATP synthase is a nuclear encoded protein which is located in the F sub(1) component of the enzyme. The…”
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Eci1p uses a PTS1 to enter peroxisomes: either its own or that of a partner, Dci1p by Yang, Xudong, Edward Purdue, P., Lazarow, Paul B.

“…Saccharomyces cerevisiae Δ 3,Δ 2-enoyl-CoA isomerase (Eci1p), encoded by ECI1, is an essential enzyme for the β-oxidation of unsaturated fatty acids. It has…”
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A serine-to-phenylalanine substitution leads to loss of alanine:glyoxylate aminotransferase catalytic activity and immunoreactivity in a patient with primary hyperoxaluria type 1 by Minatogawa, Y, Tone, S, Allsop, J, Purdue, P E, Takada, Y, Danpur, C J, Kido, R

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Peroxisomal biogenesis: multiple pathways of protein import by Purdue, P.E., Lazarow, P.B.

“…The purpose of this review is to bring together and reflect upon recent experimental results concerning the molecular mechanisms underlying the biogenesis of…”
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