Search Results - "PUPA, Serenella M"

WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer by Castagnoli, Lorenzo, Cancila, Valeria, Cordoba-Romero, Sandra L., Faraci, Simona, Talarico, Giovanna, Belmonte, Beatrice, Iorio, Marilena V., Milani, Matteo, Volpari, Tatiana, Chiodoni, Claudia, Hidalgo-Miranda, Alfredo, Tagliabue, Elda, Tripodo, Claudio, Sangaletti, Sabina, Di Nicola, Massimo, Pupa, Serenella M.

“…Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently…”
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Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness by Castagnoli, Lorenzo, Tagliabue, Elda, Pupa, Serenella M

“…Breast cancer (BC) is the most common tumour in women. Although the introduction of novel therapeutic approaches in clinical practice has dramatically improved…”
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Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy by Ciravolo, Valentina, Huber, Veronica, Ghedini, Gaia C., Venturelli, Elisabetta, Bianchi, Francesca, Campiglio, Manuela, Morelli, Daniele, Villa, Antonello, Mina, Pamela Della, Menard, Sylvie, Filipazzi, Paola, Rivoltini, Licia, Tagliabue, Elda, Pupa, Serenella M.

“…Exosomes are endosome‐derived nanovesicles actively released into the extracellular environment and biological fluids, both under physiological and…”
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Impact of in vitro SARS-CoV-2 infection on breast cancer cells by Sommariva, Michele, Dolci, Maria, Triulzi, Tiziana, Ambrogi, Federico, Dugo, Matteo, De Cecco, Loris, Le Noci, Valentino, Bernardo, Giancarla, Anselmi, Martina, Montanari, Elena, Pupa, Serenella M., Signorini, Lucia, Gagliano, Nicoletta, Sfondrini, Lucia, Delbue, Serena, Tagliabue, Elda

“…The pandemic of coronavirus disease 19 (COVID-19), caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), had severe repercussions for breast cancer…”
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Activated d16HER2 homodimers and SRC kinase mediate optimal efficacy for trastuzumab by Castagnoli, Lorenzo, Iezzi, Manuela, Ghedini, Gaia C, Ciravolo, Valentina, Marzano, Giulia, Lamolinara, Alessia, Zappasodi, Roberta, Gasparini, Patrizia, Campiglio, Manuela, Amici, Augusto, Chiodoni, Claudia, Palladini, Arianna, Lollini, Pier Luigi, Triulzi, Tiziana, Menard, Sylvie, Nanni, Patrizia, Tagliabue, Elda, Pupa, Serenella M

“…A splice isoform of the HER2 receptor that lacks exon 16 (d16HER2) is expressed in many HER2-positive breast tumors, where it has been linked with resistance…”
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The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse by Marchini, Cristina, Gabrielli, Federico, Iezzi, Manuela, Zenobi, Santa, Montani, Maura, Pietrella, Lucia, Kalogris, Cristina, Rossini, Anna, Ciravolo, Valentina, Castagnoli, Lorenzo, Tagliabue, Elda, Pupa, Serenella M, Musiani, Piero, Monaci, Paolo, Menard, Sylvie, Amici, Augusto

“…Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. Recently, a HER2 splice…”
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HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma by Zappasodi, Roberta, Ruggiero, Giusi, Guarnotta, Carla, Tortoreto, Monica, Tringali, Cristina, Cavanè, Alessandra, Cabras, Antonello D., Castagnoli, Lorenzo, Venerando, Bruno, Zaffaroni, Nadia, Gianni, Alessandro M., De Braud, Filippo, Tripodo, Claudio, Pupa, Serenella M., Di Nicola, Massimo

“…We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify…”
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Cancer Stem Cells: Devil or Savior-Looking behind the Scenes of Immunotherapy Failure by Castagnoli, Lorenzo, De Santis, Francesca, Volpari, Tatiana, Vernieri, Claudio, Tagliabue, Elda, Di Nicola, Massimo, Pupa, Serenella M

“…Although the introduction of immunotherapy has tremendously improved the prognosis of patients with metastatic cancers of different histological origins, some…”
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The Emerging Role of the Microbiota in Breast Cancer Progression by Bernardo, Giancarla, Le Noci, Valentino, Di Modica, Martina, Montanari, Elena, Triulzi, Tiziana, Pupa, Serenella M, Tagliabue, Elda, Sommariva, Michele, Sfondrini, Lucia

“…Emerging evidence suggests a profound association between the microbiota composition in the gastrointestinal tract and breast cancer progression. The gut…”
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Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution by Mazzucchelli, Serena, Signati, Lorena, Messa, Letizia, Franceschini, Alma, Bonizzi, Arianna, Castagnoli, Lorenzo, Gasparini, Patrizia, Consolandi, Clarissa, Mangano, Eleonora, Pelucchi, Paride, Cifola, Ingrid, Camboni, Tania, Severgnini, Marco, Villani, Laura, Tagliaferri, Barbara, Carelli, Stephana, Pupa, Serenella M, Cereda, Cristina, Corsi, Fabio

“…A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast cancer (BC) to…”
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Hormone receptor status influences the impact of body mass index and hyperglycemia on the risk of tumor relapse in early-stage HER2-positive breast cancer patients by Ligorio, Francesca, Zambelli, Luca, Bottiglieri, Achille, Castagnoli, Lorenzo, Zattarin, Emma, Lobefaro, Riccardo, Ottini, Arianna, Vingiani, Andrea, Pupa, Serenella M., Bianchi, Giulia V., Capri, Giuseppe, Pruneri, Giancarlo, de Braud, Filippo, Vernieri, Claudio

“…Background: High body mass index (BMI) has been associated with worse clinical outcomes in patients with early-stage breast cancer (BC), and its negative…”
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Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target by Zappasodi, Roberta, Bongarzone, Italia, Ghedini, Gaia C., Castagnoli, Lorenzo, Cabras, Antonello D., Messina, Antonella, Tortoreto, Monica, Tripodo, Claudio, Magni, Michele, Carlo-Stella, Carmelo, Gianni, Alessandro M., Pupa, Serenella M., Di Nicola, Massimo

“…We reported that the clinical efficacy of dendritic cell–based vaccination is strongly associated with immunologic responses in relapsed B-cell non-Hodgkin…”
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Fifteen-year follow-up of relapsed indolent non-Hodgkin lymphoma patients vaccinated with tumor-loaded dendritic cells by Fucà, Giovanni, Ambrosini, Margherita, Agnelli, Luca, Brich, Silvia, Sgambelluri, Francesco, Mortarini, Roberta, Pupa, Serenella M, Magni, Michele, Devizzi, Liliana, Matteucci, Paola, Cabras, Antonello, Zappasodi, Roberta, De Santis, Francesca, Anichini, Andrea, De Braud, Filippo, Gianni, Alessandro M, Di Nicola, Massimo

“…We previously published the results of a pilot study showing that vaccination with tumor-loaded dendritic cells (DCs) induced both T and B cell response and…”
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Regulation of breast cancer response to chemotherapy by fibulin-1 by PUPA, Serenella M, GIUFFRE, Sarah, MENARD, Sylvie, TAGLIABUE, Elda, CASTIGLIONI, Fabio, BERTOLA, Lorenzo, CANTU, Marco, BONGARZONE, Italia, BALDASSARI, Paola, MORTARINI, Roberta, ARGRAVES, W. Scott, ANICHINI, Andrea

“…Doxorubicin treatment was found to augment the expression of the extracellular matrix (ECM) protein fibulin-1 in cultured human breast cancer cell lines and in…”
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Identification of relevant conformational epitopes on the HER2 oncoprotein by using Large Fragment Phage Display (LFPD) by Gabrielli, Federico, Salvi, Roberto, Garulli, Chiara, Kalogris, Cristina, Arima, Serena, Tardella, Luca, Monaci, Paolo, Pupa, Serenella M, Tagliabue, Elda, Montani, Maura, Quaglino, Elena, Stramucci, Lorenzo, Curcio, Claudia, Marchini, Cristina, Amici, Augusto

“…We developed a new phage-display based approach, the Large Fragment Phage Display (LFPD), that can be used for mapping conformational epitopes on target…”
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HER2 Signaling and Breast Cancer Stem Cells: The Bridge behind HER2-Positive Breast Cancer Aggressiveness and Therapy Refractoriness by Pupa, Serenella M., Ligorio, Francesca, Cancila, Valeria, Franceschini, Alma, Tripodo, Claudio, Vernieri, Claudio, Castagnoli, Lorenzo

“…HER2 overexpression/amplification occurs in 15–20% of breast cancers (BCs) and identifies a highly aggressive BC subtype. Recent clinical progress has…”
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Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer by Ligorio, Francesca, Pellegrini, Ilaria, Castagnoli, Lorenzo, Vingiani, Andrea, Lobefaro, Riccardo, Zattarin, Emma, Santamaria, Marzia, Pupa, Serenella M., Pruneri, Giancarlo, de Braud, Filippo, Vernieri, Claudio

“…De novo or acquired resistance of cancer cells to currently available Human Epidermal Growth Factor Receptor 2 (HER2) inhibitors represents a clinical…”
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Do Pre-Diagnostic Drinking Habits Influence Breast Cancer Survival? by Allemani, Claudia, Berrino, Franco, Krogh, Vittorio, Sieri, Sabina, Pupa, Serenella M, Tagliabue, Elda, Tagliabue, Giovanna, Sant, Milena

“…Aims and background Alcohol consumption increases the risk of developing breast cancer and may also be associated with late diagnosis, recurrence, distant…”
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The d16HER2 Splice Variant: A Friend or Foe of HER2-Positive Cancers? by Castagnoli, Lorenzo, Ladomery, Michael, Tagliabue, Elda, Pupa, Serenella M

“…Human epidermal growth factor receptor 2 ( or HER2) amplification/overexpression is associated with a particularly aggressive molecular subtype of breast…”
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Intratumor lactate levels reflect HER2 addiction status in HER2‐positive breast cancer by Castagnoli, Lorenzo, Iorio, Egidio, Dugo, Matteo, Koschorke, Ada, Faraci, Simona, Canese, Rossella, Casalini, Patrizia, Nanni, Patrizia, Vernieri, Claudio, Di Nicola, Massimo, Morelli, Daniele, Tagliabue, Elda, Pupa, Serenella M.

“…Despite different molecular tumor profiles indicate that human epidermal growth factor receptor 2 (HER2) messenger RNA (mRNA) levels mirror HER2 addiction and…”
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