Search Results - "PUMIGLIA, Kevin"

Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic Stroke by Li, Qing-fen, Decker-Rockefeller, Brandee, Bajaj, Anshika, Pumiglia, Kevin

“…Cerebrovascular malformations (CVMs) affect approximately 3% of the population, risking hemorrhagic stroke, seizures, and neurological deficits. Recently Ras…”
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Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells by Shen, Qin, Goderie, Susan K., Jin, Li, Karanth, Nithin, Sun, Yu, Abramova, Natalia, Vincent, Peter, Pumiglia, Kevin, Temple, Sally

“…Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood…”
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Suppression of integrin α3β1 by α9β1 in the epidermis controls the paracrine resolution of wound angiogenesis by Longmate, Whitney M, Lyons, Scott P, Chittur, Sridar V, Pumiglia, Kevin M, Van De Water, Livingston, DiPersio, C Michael

“…Development of wound therapies is hindered by poor understanding of combinatorial integrin function in the epidermis. In this study, we generated mice with…”
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Src-induced Tyrosine Phosphorylation of VE-cadherin Is Not Sufficient to Decrease Barrier Function of Endothelial Monolayers by Adam, Alejandro P., Sharenko, Amy L., Pumiglia, Kevin, Vincent, Peter A.

“…Activation of Src family kinases (SFK) and the subsequent phosphorylation of VE-cadherin have been proposed as major regulatory steps leading to increases in…”
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Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis by Bajaj, Anshika, Li, Qing-fen, Zheng, Qingxia, Pumiglia, Kevin

“…Neurofibromatosis is a well known familial tumor syndrome, however these patients also suffer from a number of vascular anomalies. The loss of NFl from the…”
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Whole mount of adult ear skin as a model to study vascular malformations by Decker-Rockefeller, Brandee, Li, Qingfen, Pumiglia, Kevin

“…BackgroundGenetic analysis in human patients has linked mutations in PIK3CA, the catalytic subunit of PI-3′Kinase, to sporadic incidences of vascular…”
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α3β1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression by Iyer, Vandana, Pumiglia, Kevin, DiPersio, C. Michael

“…Matrix metalloproteinases facilitate cell migration and tumor invasion through their ability to proteolyse the extracellular matrix. The laminin-binding…”
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Integrin α3β1-Dependent Activation of FAK/Src Regulates Rac1-Mediated Keratinocyte Polarization on Laminin-5 by Choma, David P., Milano, Vincenzo, Pumiglia, Kevin M., Michael DiPersio, C.

“…Upon epidermal wounding, keratinocytes at the wound edge become activated, deposit newly synthesized laminin-5 into the extracellular matrix, and migrate into…”
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Integrins Regulate Microtubule Nucleating Activity of Centrosome through Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase/Extracellular Signal-regulated Kinase (MEK/ERK) Signaling by Colello, Diane, Mathew, Shomita, Ward, Rachel, Pumiglia, Kevin, LaFlamme, Susan E.

“…Microtubule nucleation is an essential step in the formation of the microtubule cytoskeleton. We recently showed that androgen and Src promote microtubule…”
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BranchAnalysis2D/3D automates morphometry analyses of branching structures by Srinivasan, Aditya, Muñoz-Estrada, Jesús, Bourgeois, Justin R., Nalwalk, Julia W., Pumiglia, Kevin M., Sheen, Volney L., Ferland, Russell J.

“…•An open-source algorithm for analysis of branching structures is presented.•Algorithm output matches output from human observers using existing analysis…”
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Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms by Bryant, Patrick, Zheng, Qingxia, Pumiglia, Kevin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation by Meadows, Kafi N., Bryant, Patrick, Pumiglia, Kevin

“…We investigated the role of Ras in vascular endothelial growth factor (VEGF)-mediated signal transduction and the promotion of angiogenic changes primary…”
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An Immortalization -Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion by LAMAR, John M, PUMIGLIA, Kevin M, DIPERSIO, C. Michael

“…Integrins, the major receptors for cell adhesion to the extracellular matrix, play important roles during tumor progression. However, it is still unclear…”
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Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells by McMullen, Meghan E., Bryant, Patrick W., Glembotski, Christopher C., Vincent, Peter A., Pumiglia, Kevin M.

“…Pathological conditions such as hypertension and hyperglycemia as well as abrasions following balloon angioplasty all lead to endothelial dysfunction that…”
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Integrins promote cytokinesis through the RSK signaling axis by Mathew, Shomita S, Nieves, Bethsaida, Sequeira, Sharon, Sambandamoorthy, Savitha, Pumiglia, Kevin, Larsen, Melinda, Laflamme, Susan E

“…Cytokinesis is the final stage in cell division. Although integrins can regulate cytokinesis, the mechanisms involved are not fully understood. In this study,…”
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Activation of Endothelial Ras Signaling Bypasses Senescence and Causes Abnormal Vascular Morphogenesis by BAJAJ, Anshika, QINGXIA ZHENG, ADAM, Alejandro, VINCENT, Peter, PUMIGLIA, Kevin

“…Angiogenesis is crucial for embryogenesis, reproduction, and wound healing and is a critical determinant of tumor growth and metastasis. The multifunctional…”
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Cell Cycle Arrest Mediated by the MEK/Mitogen-Activated Protein Kinase Pathway by Pumiglia, Kevin M., Decker, Stuart J.

“…The mitogen-activated protein kinase (MAPK) cascade plays a crucial role in the transduction of extracellular signals into responses governing growth and…”
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Pro-inflammatory angiogenesis is mediated by p38 MAP kinase by Rajashekhar, Gangaraju, Kamocka, Malgorzata, Marin, Abby, Suckow, Mark A., Wolter, William R., Badve, Sunil, Sanjeevaiah, Aravind Raj, Pumiglia, Kevin, Rosen, Elliot, Clauss, Matthias

“…Chronic inflammation is tightly linked to diseases associated with endothelial dysfunction including aberrant angiogenesis. To better understand the…”
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α3β1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway by Manohar, Asha, Shome, Swati Ghosh, Lamar, John, Stirling, Lee, Iyer, Vandana, Pumiglia, Kevin, DiPersio, C. Michael

“…Inadequate or inappropriate adhesion of epithelial cells to extracellular matrix leads to a form of apoptosis known as anoikis. During various tissue…”
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Endostatin and anastellin inhibit distinct aspects of the angiogenic process by Neskey, David M, Ambesi, Anthony, Pumiglia, Kevin M, McKeown-Longo, Paula J

“…Endostatin and anastellin, fragments of collagen type XVIII and fibronectin, respectively, belong to a family of endogenous inhibitors of angiogenesis which…”
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