Search Results - "PULLAGURLA, Manik"

Binding of isotryptamines and indenes at h5-HT6 serotonin receptors by KOLANOS, Renata, SIRIPURAPU, Uma, PULLAGURLA, Manik, RIAZ, Mohamed, SETOLA, Vince, ROTH, Bryan L, DUKAT, Małgorzata, GLENNON, Richard A

“…To determine if the indolic nitrogen atom is required for the binding of N(1)-benzyltryptamines at h5-HT(6) serotonin receptors, several isotryptamines and…”
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Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors by PULLAGURLA, Manik R, WESTKAEMPER, Richard B, GLENNON, Richard A

“…A graphics model of the human 5-HT6 receptor was constructed and automated docking studies were performed. The model suggests that 5-HT6 antagonist…”
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Synthesis and anti-HIV activity of (−)-β- d-(2 R,4 R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (−)-β- d-(2 R,4 R)-1,3-dioxolane guanosine (DXG) prodrugs by Narayanasamy, Janarthanan, Pullagurla, Manik R., Sharon, Ashoke, Wang, Jianing, Schinazi, Raymond F., Chu, Chung K.

“…Prodrugs of (−)-β- d-(2 R,4 R)-1,3-dioxolane-2,6-diamino purine (DAPD), organic salts of DAPD, 5′- l-valyl DAPD and N − 1 substituted (−)-β- d-(2 R,4…”
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Comparison of the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) and cocaine: asymmetric generalization by Khorana, Nantaka, Pullagurla, Manik R, Young, Richard, Glennon, Richard A

“…Evidence suggests that (±)3,4-methylenedioxymethamphetamine (MDMA) and psychostimulants produce similar but non-identical stimulus effects in animals. To…”
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Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors by PULLAGURLA, Manik, SIRIPURAPU, Uma, KOLANOS, Renata, BONDAREV, Mikhail L, DUKAT, Małgorzata, SETOLA, V, ROTH, B. L, GLENNON, Richard A

“…An examination of several amine-substituted analogs of N(1)-benzenesulfonylindoles reveals that although they bind at human 5-HT(6) serotonin receptors with…”
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1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands by LEE, Mase, RANGISETTY, Jagadeesh B, PULLAGURLA, Manik R, DUKAT, Małgorzata, SETOLA, Vince, ROTH, Bryan L, GLENNON, Richard A

“…4-Sulfonyl analogs of 1-(1-naphthyl)piperazine bind at human 5-HT6 receptors and represent a novel class of human 5-HT6 receptor ligands…”
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Stimulus effects of three sulfur-containing psychoactive agents by Khorana, Nantaka, Pullagurla, Manik R., Dukat, Malgorzata, Young, Richard, Glennon, Richard A.

“…Two agents gaining popularity on the illicit drug market are the phenylalkylamines 4-MTA and 2C-T-7 [or 1-(4-methylthiophenyl)-2-aminopropane and…”
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N1-Benzenesulfonylgramine and N1-Benzenesulfonylskatole: Novel 5-HT6 receptor ligand templates by PULLAGURLA, Manik R, DUKAT, Malgorzata, SETOLA, Vincent, ROTH, Bryan, GLENNON, Richard A

“…1-Benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine (3; K(i)=2.3 nM) is a 5-HT(6) receptor antagonist; removal of the 5-methoxy group (i.e., 6; K(i)=4.1 nM) has…”
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Modulation of the stimulus effects of (+)amphetamine by the 5-HT 6 antagonist MS-245 by Pullagurla, Manik, Bondareva, Tatiana, Young, Richard, Glennon, Richard A

“…5-HT 6 serotonin receptors are distributed within some dopamine terminal regions in the brain leading to suggestions that they might influence dopaminergic…”
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Evaluation of a new lead for acetylcholinesterase inhibition by Khorana, Nantaka, Markmee, Sutthatip, Ingkaninan, Kornkanok, Ruchirawat, Somsak, Kitbunnadaj, Ruengwit, Pullagurla, Manik Reddy

“…Acetylcholine is the most common neurotransmitter of the parasympathetic nervous system. Several cholinergic drugs are widely used in Alzheimer's disease,…”
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Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245 by PULLAGURLA, Manik, BONDAREVA, Tatiana, YOUNG, Richard, GLENNON, Richard A

“…5-HT(6) serotonin receptors are distributed within some dopamine terminal regions in the brain leading to suggestions that they might influence dopaminergic…”
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Possible differences in modes of agonist and antagonist binding at human 5-HT 6 receptors by Pullagurla, Manik R, Westkaemper, Richard B, Glennon, Richard A

“…A homology model of human 5-HT 6 receptors was constructed and N 1-arylsulfonyltryptamines (e.g., 3a) were found to bind in a different manner than the…”
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Binding of amine-substituted N 1-benzenesulfonylindoles at human 5-HT 6 serotonin receptors by Pullagurla, Manik, Siripurapu, Uma, Kolanos, Renata, Bondarev, Mikhail L., Dukat, Małgorzata, Setola, V., Roth, B.L., Glennon, Richard A.

“…Indoles 11 and 12 (R 1 and/or R 2 = NHCH 3 or H; R and R 3 = NH 2 or H) were examined to determine the influence of amine substituents on 5-HT 6 receptor…”
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Binding of isotryptamines and indenes at h5-HT 6 serotonin receptors by Kolanos, Renata, Siripurapu, Uma, Pullagurla, Manik, Riaz, Mohamed, Setola, Vince, Roth, Bryan L., Dukat, Małgorzata, Glennon, Richard A.

“…The binding of isotryptamines (e.g., 5, K i = 32 nM) and indenes (e.g., 11, K i = 3 nM) to h5-HT 6 serotonin receptors indicates that the presence of an…”
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1-(1-Naphthyl)piperazine as a novel template for 5-HT 6 serotonin receptor ligands by Lee, Mase, Rangisetty, Jagadeesh B., Pullagurla, Manik R., Dukat, Małgorzata, Setola, Vince, Roth, Bryan L., Glennon, Richard A.

“…4-Arylsulfone derivatives of 1-(1-naphthyl)piperazine represent a novel class of human 5-HT 6 serotonin receptor ligands. In particular, compounds such as 1f (…”
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N1-Benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT 6 receptor ligand templates by Pullagurla, Manik R., Dukat, Małgorzata, Setola, Vincent, Roth, Bryan, Glennon, Richard A.

“…1-Benzenesulfonyl-5-methoxy- N, N-dimethyltryptamine ( 3; K i=2.3 nM) is a 5-HT 6 receptor antagonist; removal of the 5-methoxy group (i.e., 6; K i=4.1 nM) has…”
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5-ZATRYPTAMINE ANALOGS AS h5-HT6 SEROTONIN RECEPTOR LIGANDS by Pullagurla, Manik, Dukat, Małgorzata, Roth, Bryan L., Setola, Vincent, Glennon, Richard A.

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Design of novel 5-HT(6) antagonists by Pullagurla, Manik Reddy

“…5-HT6 receptors are one of the recently discovered serotonin receptors. They are G-protein coupled receptors and are positively coupled to an adenylate cyclase…”
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Design of novel 5-HT(6) antagonists by Pullagurla, Manik Reddy

“…5-HT6 receptors are one of the recently discovered serotonin receptors. They are G-protein coupled receptors and are positively coupled to an adenylate cyclase…”
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