Search Results - "PUI, C. H"

Infection-related complications during treatment for childhood acute lymphoblastic leukemia by Inaba, H., Pei, D., Wolf, J., Howard, S.C., Hayden, R.T., Go, M., Varechtchouk, O., Hahn, T., Buaboonnam, J., Metzger, M.L., Rubnitz, J.E., Ribeiro, R.C., Sandlund, J.T., Jeha, S., Cheng, C., Evans, W.E., Relling, M.V., Pui, C.-H.

“…Comprehensive studies on neutropenia and infection-related complications in patients with acute lymphoblastic leukemia (ALL) are lacking. We evaluated…”
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Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update by Relling, M V, Gardner, E E, Sandborn, W J, Schmiegelow, K, Pui, C-H, Yee, S W, Stein, C M, Carrillo, M, Evans, W E, Hicks, J K, Schwab, M, Klein, T E

“…The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Methyltransferase Genotype and Thiopurine Dosing was originally…”
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Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing by Relling, MV, Gardner, EE, Sandborn, WJ, Schmiegelow, K, Pui, C‐H, Yee, SW, Stein, CM, Carrillo, M, Evans, WE, Klein, TE

“…Thiopurine methyltransferase (TPMT) activity exhibits monogenic co‐dominant inheritance, with ethnic differences in the frequency of occurrence of variant…”
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Clinical impact of minimal residual disease in children with different subtypes of acute lymphoblastic leukemia treated with Response-Adapted therapy by Pui, C-H, Pei, D, Raimondi, S C, Coustan-Smith, E, Jeha, S, Cheng, C, Bowman, W P, Sandlund, J T, Ribeiro, R C, Rubnitz, J E, Inaba, H, Gruber, T A, Leung, W H, Yang, J J, Downing, J R, Evans, W E, Relling, M V, Campana, D

“…To determine the clinical significance of minimal residual disease (MRD) in patients with prognostically relevant subtypes of childhood acute lymphoblastic…”
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The association of environmental factors with neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia (ALL) by Nigro, S. E., Hall, L. P., Harman, J., Willard, V. W., Conklin, H. M., Pui, C.-H., Jeha, S., Jacola, L. M.

“…Purpose To investigate the association of environmental factors, rehabilitation services during therapy and socioeconomic status (SES – insurance type), with…”
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Pharmacogenomics and Individualized Medicine: Translating Science Into Practice by Crews, K R, Hicks, J K, Pui, C-H, Relling, M V, Evans, W E

“…Research on genes and medications has advanced our understanding of the genetic basis of individual drug responses. The aim of pharmacogenomics is to develop…”
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Cognitive Outcomes Following Contemporary Treatment Without Cranial Irradiation for Childhood Acute Lymphoblastic Leukemia by CONKLIN, H. M, KRULL, K. R, REDDICK, W. E, PEI, D, CHENG, C, PUI, C. H

“…Treatment of acute lymphoblastic leukemia (ALL) has included the use of prophylactic cranial irradiation in up to 20% of children with high-risk disease…”
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Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia by Liu, C, Kawedia, J D, Cheng, C, Pei, D, Fernandez, C A, Cai, X, Crews, K R, Kaste, S C, Panetta, J C, Bowman, W P, Jeha, S, Sandlund, J T, Evans, W E, Pui, C-H, Relling, M V

“…Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We…”
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Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia by Pui, C H, Pei, D, Sandlund, J T, Ribeiro, R C, Rubnitz, J E, Raimondi, S C, Onciu, M, Campana, D, Kun, L E, Jeha, S, Cheng, C, Howard, S C, Metzger, M L, Bhojwani, D, Downing, J R, Evans, W E, Relling, M V

“…We analyzed the long-term outcome of 1011 patients treated in five successive clinical trials (Total Therapy Studies 11, 12, 13A, 13B, and 14) between 1984 and…”
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Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia by IMAI, C, MIHARA, K, ANDREANSKY, M, NICHOLSON, I. C, PUI, C-H, GEIGER, T. L, CAMPANA, D

“…To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we transduced T lymphocytes with anti-CD19 chimeric receptors, consisting…”
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Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia by Stocco, G, Cheok, MH, Crews, KR, Dervieux, T, French, D, Pei, D, Yang, W, Cheng, C, Pui, C‐H, Relling, MV, Evans, WE

“…The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine‐induced adverse events has not been investigated in the…”
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Rapid memory T-cell reconstitution recapitulating CD45RA-depleted haploidentical transplant graft content in patients with hematologic malignancies by Triplett, B M, Shook, D R, Eldridge, P, Li, Y, Kang, G, Dallas, M, Hartford, C, Srinivasan, A, Chan, W K, Suwannasaen, D, Inaba, H, Merchant, T E, Pui, C-H, Leung, W

“…T-cell depletion of an HLA-haploidentical graft is often used to prevent GVHD, but the procedure may lead to increased graft failure, relapse and infections…”
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The Impact of Persistent Leukoencephalopathy on Brain White Matter Microstructure in Long-Term Survivors of Acute Lymphoblastic Leukemia Treated with Chemotherapy Only by Sabin, N D, Cheung, Y T, Reddick, W E, Bhojwani, D, Liu, W, Glass, J O, Brinkman, T M, Hwang, S N, Srivastava, D, Pui, C-H, Robison, L L, Hudson, M M, Krull, K R

“…Survivors of acute lymphoblastic leukemia are at risk for neurocognitive deficits and leukoencephalopathy. We performed a longitudinal assessment of…”
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Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer by Inaba, H., Khan, R. B., Laningham, F. H., Crews, K. R., Pui, C.-H., Daw, N. C.

“…Background: Little information is available about the diagnosis and management of acute methotrexate (MTX)-induced encephalopathy. Methods: We reviewed…”
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Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait by Liu, C, Yang, W, Pei, D, Cheng, C, Smith, C, Landier, W, Hageman, L, Chen, Y, Yang, JJ, Crews, KR, Kornegay, N, Karol, SE, Wong, FL, Jeha, S, Sandlund, JT, Ribeiro, RC, Rubnitz, JE, Metzger, ML, Pui, C‐H, Evans, WE, Bhatia, S, Relling, MV

“…We performed a genomewide association study (GWAS) of primary erythrocyte thiopurine S‐methyltransferase (TPMT) activity in children with leukemia (n = 1,026)…”
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ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy by Bhojwani, D, Pei, D, Sandlund, J T, Jeha, S, Ribeiro, R C, Rubnitz, J E, Raimondi, S C, Shurtleff, S, Onciu, M, Cheng, C, Coustan-Smith, E, Bowman, W P, Howard, S C, Metzger, M L, Inaba, H, Leung, W, Evans, W E, Campana, D, Relling, M V, Pui, C-H

“…ETV6-RUNX1 fusion is the most common genetic aberration in childhood acute lymphoblastic leukemia (ALL). To evaluate whether outcomes for this drug-sensitive…”
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Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity by Chan, W K, Suwannasaen, D, Throm, R E, Li, Y, Eldridge, P W, Houston, J, Gray, J T, Pui, C-H, Leung, W

“…Chimeric antigen receptor (CAR)-redirected cellular therapy is an attractive modality for cancer treatment. We hypothesized that allogeneic CAR-engineered…”
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Genome‐Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy by Liu, Y, Fernandez, CA, Smith, C, Yang, W, Cheng, C, Panetta, JC, Kornegay, N, Liu, C, Ramsey, LB, Karol, SE, Janke, LJ, Larsen, EC, Winick, N, Carroll, WL, Loh, ML, Raetz, EA, Hunger, SP, Devidas, M, Yang, JJ, Mullighan, CG, Zhang, J, Evans, WE, Jeha, S, Pui, C‐H, Relling, MV

“…Remission induction therapy for acute lymphoblastic leukemia (ALL) includes medications that may cause hepatotoxicity, including asparaginase. We used a…”
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Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1 by Jeha, S, Pei, D, Raimondi, S C, Onciu, M, Campana, D, Cheng, C, Sandlund, J T, Ribeiro, R C, Rubnitz, J E, Howard, S C, Downing, J R, Evans, W E, Relling, M V, Pui, C-H

“…To evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/ TCF3/PBX1 ,…”
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ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence by Yang, W, Treviño, L R, Yang, J J, Scheet, P, Pui, C-H, Evans, W E, Relling, M V

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