Search Results - "PUHR, Martin"

Interleukin-6 and prostate cancer: Current developments and unsolved questions by Culig, Zoran, Puhr, Martin

“…Interleukin (IL)-6 is a pro-inflammatory cytokine that is expressed in prostate tumors and in the stromal tumor micro-enviroment. It is known to regulate…”
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Interleukin-6: A multifunctional targetable cytokine in human prostate cancer by Culig, Zoran, Puhr, Martin

“…► Interleukin-6 is a multifunctional cytokine which regulates growth of prostate cancer. ► Stimulation of androgen receptor activity by interleukin-6 may…”
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The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy by Puhr, Martin, Hoefer, Julia, Eigentler, Andrea, Ploner, Christian, Handle, Florian, Schaefer, Georg, Kroon, Jan, Leo, Angela, Heidegger, Isabel, Eder, Iris, Culig, Zoran, Van der Pluijm, Gabri, Klocker, Helmut

“…The major obstacle in the management of advanced prostate cancer is the occurrence of resistance to endocrine therapy. Although the androgen receptor (AR) has…”
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Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205 by Puhr, Martin, Hoefer, Julia, Schäfer, Georg, Erb, Holger H.H, Oh, Su Jung, Klocker, Helmut, Heidegger, Isabel, Neuwirt, Hannes, Culig, Zoran

“…Docetaxel is a standard chemotherapy for patients with metastatic prostate cancer. However, the response is rather limited and not all of the patients benefit…”
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The role of epithelial–mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel‐resistant prostate cancer by Hanrahan, Karen, O'Neill, Amanda, Prencipe, Maria, Bugler, Jane, Murphy, Lisa, Fabre, Aurelie, Puhr, Martin, Culig, Zoran, Murphy, Keefe, Watson, R. William

“…Docetaxel is the main treatment for advanced castration‐resistant prostate cancer; however, resistance eventually occurs. The development of intratumoral…”
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ZEB1‐associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat by Meidhof, Simone, Brabletz, Simone, Lehmann, Waltraut, Preca, Bogdan‐Tiberius, Mock, Kerstin, Ruh, Manuel, Schüler, Julia, Berthold, Maria, Weber, Anika, Burk, Ulrike, Lübbert, Michael, Puhr, Martin, Culig, Zoran, Wellner, Ulrich, Keck, Tobias, Bronsert, Peter, Küsters, Simon, Hopt, Ulrich T, Stemmler, Marc P, Brabletz, Thomas

“…Therapy resistance is a major clinical problem in cancer medicine and crucial for disease relapse and progression. Therefore, the clinical need to overcome it,…”
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Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells by Ippolito, Luigi, Marini, Alberto, Cavallini, Lorenzo, Morandi, Andrea, Pietrovito, Laura, Pintus, Gianfranco, Giannoni, Elisa, Schrader, Thomas, Puhr, Martin, Chiarugi, Paola, Taddei, Maria Letizia

“…Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support…”
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miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer by Pasqualini, Lorenza, Bu, Huajie, Puhr, Martin, Narisu, Narisu, Rainer, Johannes, Schlick, Bettina, Schäfer, Georg, Angelova, Mihaela, Trajanoski, Zlatko, Börno, Stefan T, Schweiger, Michal R, Fuchsberger, Christian, Klocker, Helmut

“…The normal prostate as well as early stages and advanced prostate cancer (PCa) require a functional androgen receptor (AR) for growth and survival. The recent…”
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Prostate Cancer's Silent Partners: Fibroblasts and Their Influence on Glutamine Metabolism Manipulation by Hönscheid, Pia V, Baretton, Gustavo B, Puhr, Martin, Siciliano, Tiziana, Israel, Justus S, Stope, Matthias B, Ebersbach, Celina, Beier, Alicia-Marie K, Thomas, Christian, Erb, Holger H H

“…Cancer-associated fibroblast (CAF)s in the tumour microenvironment (TME) modulate the extracellular matrix, interact with cancer cells, and facilitate…”
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The impact of androgen-induced translation in modulating androgen receptor activity by Israel, Justus S, Marcelin, Laura-Maria, Mehralivand, Sherif, Scholze, Jana, Hofmann, Jörg, Stope, Matthias B, Puhr, Martin, Thomas, Christian, Erb, Holger H. H

“…Abstract Introduction Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives…”
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New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium by Mehralivand, Sherif, Thomas, Christian, Puhr, Martin, Claessens, Frank, van de Merbel, Arjanneke F, Dubrovska, Anna, Jenster, Guido, Bernemann, Christof, Sommer, Ulrich, Erb, Holger H H

“…The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate…”
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Emerging frontiers in androgen receptor research for prostate Cancer: insights from the 2nd international androgen receptor Symposium by Israel, Justus Simon, Marcelin, Laura-Maria, Thomas, Christian, Szczyrbová, Eva, Fuessel, Susanne, Puhr, Martin, Linxweiler, Johannes, Yalala, Shivani, Zwart, Wilbert T, Baniahmad, Aria, van Goubergen, Jasper, Itkonen, Harri M, Sharp, Adam, O'Neill, Edward, Pretze, Marc, Miederer, Matthias, Erb, Holger H H

“…Continued exploration of the androgen receptor (AR) is crucial, as it plays pivotal roles in diverse diseases such as prostate cancer (PCa), serving as a…”
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Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer by Kroon, Jan, Puhr, Martin, Buijs, Jeroen T, van der Horst, Geertje, Hemmer, Daniëlle M, Marijt, Koen A, Hwang, Ming S, Masood, Motasim, Grimm, Stefan, Storm, Gert, Metselaar, Josbert M, Meijer, Onno C, Culig, Zoran, van der Pluijm, Gabri

“…Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used in combination with…”
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Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells by Vakhrusheva, Olesya, Erb, Holger H H, Bräunig, Vitus, Markowitsch, Sascha D, Schupp, Patricia, Baer, Patrick C, Slade, Kimberly Sue, Thomas, Anita, Tsaur, Igor, Puhr, Martin, Culig, Zoran, Cinatl, Jr, Jindrich, Michaelis, Martin, Efferth, Thomas, Haferkamp, Axel, Juengel, Eva

“…Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to…”
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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe by Drápela, Stanislav, Khirsariya, Prashant, Weerden, Wytske M., Fedr, Radek, Suchánková, Tereza, Búzová, Diana, Červený, Jan, Hampl, Aleš, Puhr, Martin, Watson, William R., Culig, Zoran, Krejčí, Lumír, Paruch, Kamil, Souček, Karel

“…As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic…”
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Antidiabetic drugs influence molecular mechanisms in prostate cancer by Pircher, Andreas, Zieher, Martin, Eigentler, Andrea, Pichler, Renate, Schäfer, Georg, Fritz, Josef, Puhr, Martin, Steiner, Eberhard, Horninger, Wolfgang, Klocker, Helmut, Heidegger, Isabel

“…Background: We investigated the role of diabetes mellitus (DM) and the molecular mechanisms of antidiabetic drugs in prostate cancer (PCa). Patients and…”
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Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo by Gu, Lei, Vogiatzi, Paraskevi, Puhr, Martin, Dagvadorj, Ayush, Lutz, Jacqueline, Ryder, Amy, Addya, Sankar, Fortina, Paolo, Cooper, Carlton, Leiby, Benjamin, Dasgupta, Abhijit, Hyslop, Terry, Bubendorf, Lukas, Alanen, Kalle, Mirtti, Tuomas, Nevalainen, Marja T

“…There are no effective therapies for disseminated prostate cancer. Constitutive activation of Stat5 in prostate cancer is associated with cancer lesions of…”
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Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer by Pardella, Elisa, Pranzini, Erica, Nesi, Ilaria, Parri, Matteo, Spatafora, Pietro, Torre, Eugenio, Muccilli, Angela, Castiglione, Francesca, Fambrini, Massimiliano, Sorbi, Flavia, Cirri, Paolo, Caselli, Anna, Puhr, Martin, Klocker, Helmut, Serni, Sergio, Raugei, Giovanni, Magherini, Francesca, Taddei, Maria Letizia

“…Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor…”
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Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways by PUHR, Martin, SANTER, Frédéric R, NEUWIRT, Hannes, SUSANI, Martin, NEMETH, Jeffrey A, HOBISCH, Alfred, KENNER, Lukas, CULIG, Zoran

“…Suppressor of cytokine signaling-3 (SOCS-3) acts as a negative feedback regulator of the Janus-activated kinase/signal transducers and activators of…”
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PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells by Puhr, Martin, Hoefer, Julia, Neuwirt, Hannes, Eder, Iris E, Kern, Johann, Schäfer, Georg, Geley, Stephan, Heidegger, Isabel, Klocker, Helmut, Culig, Zoran

“…Occurrence of an inherent or acquired resistance to the chemotherapeutic drug docetaxel is a major burden for patients suffering from different kinds of…”
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