Search Results - "PUGH, W"

Social Complexity and the Middle Preclassic Lowland Maya by Pugh, Timothy W.

“…Intensified social complexity emerged in some parts of the lowland Maya region during the Middle Preclassic period (800–300 BC). Though data for Middle…”
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High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq by Schödel, Johannes, Oikonomopoulos, Spyros, Ragoussis, Jiannis, Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.

“…Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the response of all mammalian cells to alterations in oxygen tension…”
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Hypoxia and HIF pathway in cancer and the placenta by Macklin, Philip S, McAuliffe, James, Pugh, Christopher W, Yamamoto, Atsushi

“…Abstract In this review we note that the placenta and cancer both develop in microenvironments in which there are gradients of oxygen availability. Whilst…”
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Regulation of angiogenesis by hypoxia: role of the HIF system by Ratcliffe, Peter J, Pugh, Christopher W

“…The regulation of angiogenesis by hypoxia is an important component of homeostatic mechanisms that link vascular oxygen supply to metabolic demand. Molecular…”
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Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing by Webb, James D, Coleman, Mathew L, Pugh, Christopher W

“…This article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the…”
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ZCCHC8 , the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation by Gable, Dustin L, Gaysinskaya, Valeriya, Atik, Christine C, Talbot, Jr, C Conover, Kang, Byunghak, Stanley, Susan E, Pugh, Elizabeth W, Amat-Codina, Nuria, Schenk, Kara M, Arcasoy, Murat O, Brayton, Cory, Florea, Liliana, Armanios, Mary

“…Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders. We used genome-wide linkage to…”
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Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials by Yeh, Tzu-Lan, Leissing, Thomas M, Abboud, Martine I, Thinnes, Cyrille C, Atasoylu, Onur, Holt-Martyn, James P, Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T, Leung, Ivanhoe K H, Morcrette, Helen, Clifton, Ian J, Claridge, Timothy D W, Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J, Chowdhury, Rasheduzzaman, Pugh, Christopher W, Schofield, Christopher J

“…Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus…”
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Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases by Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.

“…The hypoxia-inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an α/β-heterodimeric transcription factor that…”
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Gastroretentive dosage forms: Overview and special case of Helicobacter pylori by Bardonnet, P.L., Faivre, V., Pugh, W.J., Piffaretti, J.C., Falson, F.

“…The challenge to develop efficient gastroretentive dosage forms began about 20 years ago, following the discovery of Helicobacter pylori by Warren and…”
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Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling by Adam, Julie, Hatipoglu, Emine, O'Flaherty, Linda, Ternette, Nicola, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Nye, Emma, Stamp, Gordon W., Wolhuter, Kathryn, Stevens, Marcus, Fischer, Roman, Carmeliet, Peter, Maxwell, Patrick H., Pugh, Chris W., Frizzell, Norma, Soga, Tomoyoshi, Kessler, Benedikt M., El-Bahrawy, Mona, Ratcliffe, Peter J., Pollard, Patrick J.

“…The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose inactivation is associated with the development of leiomyomata, renal cysts,…”
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases by Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.

“…The response to hypoxia in animals involves the expression of multiple genes regulated by the αβ-hypoxia-inducible transcription factors (HIFs). The…”
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Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor by Appelhoff, Rebecca J., Tian, Ya-Min, Raval, Raju R., Turley, Helen, Harris, Adrian L., Pugh, Christopher W., Ratcliffe, Peter J., Gleadle, Jonathan M.

“…Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis. The heterodimeric HIF complex is…”
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Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression by Schödel, Johannes, Bardella, Chiara, Sciesielski, Lina K, Brown, Jill M, Pugh, Chris W, Buckle, Veronica, Tomlinson, Ian P, Ratcliffe, Peter J, Mole, David R

“…Johannes Schödel and colleagues report the identification of a distant transcriptional enhancer of CCND1 at the recently identified renal cell carcinoma…”
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Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma by Raval, Raju R., Lau, Kah Weng, Tran, Maxine G. B., Sowter, Heidi M., Mandriota, Stefano J., Li, Ji-Liang, Pugh, Christopher W., Maxwell, Patrick H., Harris, Adrian L., Ratcliffe, Peter J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice by Milkiewicz, Malgorzata, Pugh, Christopher W., Egginton, Stuart

“…Hypoxia-inducible factor (HIF) modulates transcriptional control of several genes involved in vascular growth and cellular metabolism. HIF activity can be…”
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Using Static Analysis to Find Bugs by Ayewah, N., Pugh, W., Hovemeyer, D., Morgenthaler, J.D., Penix, J.

“…Static analysis examines code in the absence of input data and without running the code. It can detect potential security violations (SQL injection), runtime…”
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Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation by Masson, Norma, Willam, Carsten, Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.

“…Oxygen‐dependent proteolytic destruction of hypoxia‐inducible factor‐α (HIF‐α) subunits plays a central role in regulating transcriptional responses to…”
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Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes by Adam, Julie, Ramracheya, Reshma, Chibalina, Margarita V., Ternette, Nicola, Hamilton, Alexander, Tarasov, Andrei I., Zhang, Quan, Rebelato, Eduardo, Rorsman, Nils J.G., Martín-del-Río, Rafael, Lewis, Amy, Özkan, Gizem, Do, Hyun Woong, Spégel, Peter, Saitoh, Kaori, Kato, Keiko, Igarashi, Kaori, Kessler, Benedikt M., Pugh, Christopher W., Tamarit-Rodriguez, Jorge, Mulder, Hindrik, Clark, Anne, Frizzell, Norma, Soga, Tomoyoshi, Ashcroft, Frances M., Silver, Andrew, Pollard, Patrick J., Rorsman, Patrik

“…We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells…”
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Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway by Hodson, Emma J., Nicholls, Lynn G., Turner, Philip J., Llyr, Ronan, Fielding, James W., Douglas, Gillian, Ratnayaka, Indrika, Robbins, Peter A., Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie

“…Key points Sustained hypoxic exposure increases ventilatory sensitivity to hypoxia as part of physiological acclimatisation. Oxygen‐sensitive signals are…”
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Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors by Tian, Ya-Min, Yeoh, Kar Kheng, Lee, Myung Kyu, Eriksson, Tuula, Kessler, Benedikt M., Kramer, Holger B., Edelmann, Mariola J., Willam, Carsten, Pugh, Christopher W., Schofield, Christopher J., Ratcliffe, Peter J.

“…Hypoxia inducible factor (HIF) is regulated by dual pathways involving oxygen-dependent prolyl and asparaginyl hydroxylation of its α-subunits. Prolyl…”
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