Search Results - "PUGA, Alvaro"

Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease by Puga, Alvaro

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the induction of the CYP1 family of cytochrome P450s and of…”
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Effects of arsenic exposure on DNA methylation and epigenetic gene regulation by Reichard, John F, Puga, Alvaro

“…Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results…”
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Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood by de Gannes, Matthew, Koch, Sheryl E., Puga, Alvaro, Rubinstein, Jack

“…Congenital heart disease (CHD) is the most common congenital abnormality. A precise etiology for CHD remains elusive, but likely results from interactions…”
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Chromium Cross-Links Histone Deacetylase 1-DNA Methyltransferase 1 Complexes to Chromatin, Inhibiting Histone-Remodeling Marks Critical for Transcriptional Activation by Schnekenburger, Michael, Talaska, Glenn, Puga, Alvaro

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis by Marlowe, Jennifer L., Puga, Alvaro

“…Most effects of exposure to halogenated and polycyclic aromatic hydrocarbons are mediated by the aryl hydrocarbon receptor (AHR). It has long been recognized…”
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Long term low-dose arsenic exposure induces loss of DNA methylation by Reichard, John F., Schnekenburger, Michael, Puga, Alvaro

“…Arsenic ranks as the number one toxic environmental contaminant. In humans, arsenic exposure is associated with various forms of cancer, cardiovascular and…”
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Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells by Ko, Chia‐I, Fan, Yunxia, de Gannes, Matthew, Wang, Qin, Xia, Ying, Puga, Alvaro

“…Lack of cell cycle checkpoints and uninterrupted passage through S‐phase continuously renew the embryonic stem (ES) cell population and maintain pluripotency…”
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Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives by Grandjean, Philippe, Barouki, Robert, Bellinger, David C, Casteleyn, Ludwine, Chadwick, Lisa H, Cordier, Sylvaine, Etzel, Ruth A, Gray, Kimberly A, Ha, Eun-Hee, Junien, Claudine, Karagas, Margaret, Kawamoto, Toshihiro, Paige Lawrence, B, Perera, Frederica P, Prins, Gail S, Puga, Alvaro, Rosenfeld, Cheryl S, Sherr, David H, Sly, Peter D, Suk, William, Sun, Qi, Toppari, Jorma, van den Hazel, Peter, Walker, Cheryl L, Heindel, Jerrold J

“…The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the most rapidly expanding areas of biomedical research. Environmental stressors…”
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The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis by YUNXIA FAN, BOIVIN, Gregory P, KNUDSEN, Erik S, NEBERT, Daniel W, YING XIA, PUGA, Alvaro

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological and toxic effects of its xenobiotic ligands…”
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Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29⁻31 August 2018 in Paris, France by Esser, Charlotte, Lawrence, B Paige, Sherr, David H, Perdew, Gary H, Puga, Alvaro, Barouki, Robert, Coumoul, Xavier

“…In a time where "translational" science has become a mantra in the biomedical field, it is reassuring when years of research into a biological phenomenon…”
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Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood by Li, Yue, Xie, Changchun, Murphy, Susan K, Skaar, David, Nye, Monica, Vidal, Adriana C, Cecil, Kim M, Dietrich, Kim N, Puga, Alvaro, Jirtle, Randy L, Hoyo, Cathrine

“…Lead exposure during early development causes neurodevelopmental disorders by unknown mechanisms. Epidemiologic studies have focused recently on determining…”
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Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions by Wang, Qin, Kurita, Hisaka, Carreira, Vinicius, Ko, Chia-I, Fan, Yunxia, Zhang, Xiang, Biesiada, Jacek, Medvedovic, Mario, Puga, Alvaro

“…The AHR is a ligand-activated transcription factor that mediates gene-environment interactions. Genome-wide expression profiling during differentiation of…”
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Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells by Abiko, Yumi, Puga, Alvaro, Kumagai, Yoshito

“…Highly reactive quinone species produced by photooxidation and/or metabolic activation of mono- or bi-aromatic hydrocarbons modulate cellular homeostasis and…”
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Hexavalent chromium promotes differential binding of CTCF to its cognate sites in Euchromatin by VonHandorf, Andrew, Zablon, Hesbon A., Biesiada, Jacek, Zhang, Xiang, Medvedovic, Mario, Puga, Alvaro

“…Hexavalent chromium compounds are well-established respiratory carcinogens to which humans are commonly exposed in industrial and occupational settings. In…”
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MAP3K1 regulates female reproductive tract development by Kimura, Eiki, Mongan, Maureen, Xiao, Bo, Christianto, Antonius, Wang, Jingjing, Carreira, Vinicius S, Bolon, Brad, Zhang, Xiang, Burns, Katherine A, Biesiada, Jacek, Medvedovic, Mario, Puga, Alvaro, Xia, Ying

“…Mitogen-activated protein 3 kinase 1 (MAP3K1) has a plethora of cell type-specific functions not yet fully understood. Herein, we describe a role for MAP3K1 in…”
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Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult by Carreira, Vinicius S, Fan, Yunxia, Kurita, Hisaka, Wang, Qin, Ko, Chia-I, Naticchioni, Mindi, Jiang, Min, Koch, Sheryl, Zhang, Xiang, Biesiada, Jacek, Medvedovic, Mario, Xia, Ying, Rubinstein, Jack, Puga, Alvaro

“…The Developmental Origins of Health and Disease (DOHaD) Theory proposes that the environment encountered during fetal life and infancy permanently shapes…”
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Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes by Carreira, Vinicius S, Fan, Yunxia, Wang, Qing, Zhang, Xiang, Kurita, Hisaka, Ko, Chia-I, Naticchioni, Mindi, Jiang, Min, Koch, Sheryl, Medvedovic, Mario, Xia, Ying, Rubinstein, Jack, Puga, Alvaro

“…Congenital heart disease (CHD) is the most common congenital abnormality and one of the leading causes of newborn death throughout the world. Despite much…”
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The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis by Marlowe, Jennifer L, Fan, Yunxia, Chang, Xiaoqing, Peng, Li, Knudsen, Erik S, Xia, Ying, Puga, Alvaro

“…Cellular stress by DNA damage induces checkpoint kinase-2 (CHK2)-mediated phosphorylation and stabilization of the E2F1 transcription factor, leading to…”
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Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin by Ovesen, Jerald L, Schnekenburger, Michael, Puga, Alvaro

“…Posttranslational histone modifications are a critical regulatory mechanism of gene transcription. Previous studies from our laboratory have shown that…”
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Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes by VonHandorf, Andrew, Sánchez-Martín, Francisco Javier, Biesiada, Jacek, Zhang, Hongxia, Zhang, Xiang, Medvedovic, Mario, Puga, Alvaro

“…Hexavalent chromium compounds are well-established respiratory carcinogens used in industrial processes. While inhalation exposure constitutes an occupational…”
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