Search Results - "PSYCHIATRIC GENETICS"

Brain-derived neurotrophic factor and schizophrenia by Di Carlo, Pasquale, Punzi, Giovanna, Ursini, Gianluca

“…The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term…”
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Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia by Curtis, David

“…BACKGROUNDThe polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to…”
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Genetic risk factors and gene–environment interactions in adult and childhood attention-deficit/hyperactivity disorder by Palladino, Viola S, McNeill, Rhiannon, Reif, Andreas, Kittel-Schneider, Sarah

“…Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, genetic studies have revealed…”
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A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans by Bakermans-Kranenburg, Marian J, van IJzendoorn, Marinus H

“…Variation in the oxytocin receptor (OXTR) gene may partly explain individual differences in oxytocin-related social behavior. Two single nucleotide…”
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Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights by Zamanpoor, Mansour

“…Schizophrenia is a common multigenic and debilitating neurological disorder characterized by chronic psychotic symptoms and psychosocial impairment. Complex…”
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Applications of Mendelian randomization in psychiatry: a comprehensive systematic review by Saccaro, Luigi F., Gasparini, Simone, Rutigliano, Grazia

“…Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify their risk factors and causative mechanisms due to their…”
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Offspring of parents with schizophrenia, bipolar disorder, and depression: a review of familial high-risk and molecular genetics studies by Sandstrom, Andrea, Sahiti, Qendresa, Pavlova, Barbara, Uher, Rudolf

“…Offspring of parents with severe mental illness, including schizophrenia, bipolar disorder, and major depressive disorder, have a one-in-three risk of…”
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Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool by Odintsova, Veronika V., Roetman, Peter J., Ip, Hill F., Pool, René, Van der Laan, Camiel M., Tona, Klodiana-Daphne, Vermeiren, Robert R.J.M., Boomsma, Dorret I.

“…There are substantial differences, or variation, between humans in aggression, with its molecular genetic basis mostly unknown. This review summarizes…”
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A new case with coexistence of mosaic 48,XYYY/47,XYY, and CACNA1E variant in autism spectrum disorder by Kalayci, Aysel, Agirbasli, Deniz, Serdengecti, Nihal, Alay, Mustafa Tarik, Tarakcioglu, Mahmut Cem, Seven, Mehmet

“…Autism spectrum disorder (ASD) is a genetically heterogeneous neurobehavioral disorder. The etiology and the inheritance pattern are usually multifactorial…”
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Association of NTRK2 gene with suicidality: a meta-analysis by Ye, Wenzhu, Zhang, Ruo Su, Hosang, Georgina M., Fabbri, Chiara, King, Nicole, Strauss, John, Jones, Ian, Jones, Lisa, Breen, Gerome, Kennedy, James L., Vincent, John B., Zai, Clement C.

“…Previous studies have shown that genes in brain development pathways may have important roles in affecting risk of suicidal behaviors, with our previous…”
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The association among multiple-site chronic pain, sedentary behavior, and major depressive disorders: a mendelian randomization study by Li, Nan-Xi, Chen, Cheng-Feng, Zhang, Bin

“…Observational studies have reported that major depressive disorder (MDD) is associated with sedentary behavior (SB) and multiple chronic pain (MCP), but their…”
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Genomics and pharmacogenomics of cluster headache: implications for personalized management? A systematic review by Isayeva, Ulker, Paribello, Pasquale, Ginelli, Enrico, Pisanu, Claudia, Comai, Stefano, Carpiniello, Bernardo, Squassina, Alessio, Manchia, Mirko

“…The role of genetic factors in cluster headache etiology, suggested by familial and twin studies, remains ill-defined, with the exact pathophysiological…”
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Further evidence of the role of microRNA in schizophrenia: a case report by Sanjuan-Ortiz, Cecilia, Rojo-Bofill, Luis M, Rosello, Monica, Orellana, Carmen, Iranzo-Tatay, Carmen

“…According to the neurodevelopmental hypothesis of schizophrenia, genetic predisposing factors cause abnormalities in neural functions, leading to the disease…”
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Prenatal diagnosis and molecular cytogenetic analyses of a homozygous Robertsonian translocation family with novel mosaic Robertsonian fission karyotype by Xu, Zhen, Luo, Huili, Li, Manman, OuYang, Liu, Xia, Zhi

“…Approximately one person in 1000 is a Robertsonian translocation carrier. Errors in the formation of eggs (or more rarely of sperms) may be the cause of…”
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Genetic association of SLC6A3 (dopamine transporter) gene polymorphisms with personality disorders and substance abuse disorders: a systematic review and meta-analysis by Vogiatzoglou, Angeliki V, Kontou, Panagiota I, Bagos, Pantelis G, Braliou, Georgia G

“…Personality disorders (PD) are characterized by socially dysfunctional behavioral patterns that affect patients and show higher incidence rates within…”
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Comparison of microRNA expression levels in patients with schizophrenia before and after electroconvulsive therapy by Usta Saglam, Nazife Gamze, Duz, Mehmet Bugrahan, Salman Yilmaz, Seda, Ozen, Mustafa, Balcioglu, Ibrahim

“…Exploring the role of microRNAs in the antipsychotic efficacy of electroconvulsive therapy (ECT) will contribute to understanding the underlying mechanism…”
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Whole-exome sequencing implicates 16p13.2 as a risk locus for attention-deficit/hyperactivity disorder in the Faroese population by Gregersen, Noomi O, Lydersen, Leivur N, Biskopstø, Marjun, Zachariasen, Julia F, Jespersen, Rókur F, Stórá, Tórmóður, Andorsdóttir, Guðrið, Wang, August G

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Arginine, glycine, and creatine supplementation improves symptoms in a female with creatine transporter deficiency by Tauer, Kara, Theile, Caroline, Owens, Joshua W, Cecil, Kim M, Shillington, Amelle

“…X-linked creatine transporter deficiency is caused by hemizygous or heterozygous pathogenic variants in SLC6A8 that cause neuropsychiatric symptoms because of…”
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Epigenetics in bipolar disorder: a critical review of the literature by Legrand, Adrien, Iftimovici, Anton, Khayachi, Anouar, Chaumette, Boris

“…INTRODUCTIONBipolar disorder (BD) is a chronic, disabling disease characterised by alternate mood episodes, switching through depressive and manic/hypomanic…”
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Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders by Li, Wenqianglong, Zhou, Hang, Thygesen, Johan H, Heydtmann, Mathis, Smith, Iain, Degenhardt, Franziska, Nöthen, Markus, Morgan, Marsha Y, Kranzler, Henry R, Gelernter, Joel, Bass, Nicholas, McQuillin, Andrew

“…While progress has been made in determining the genetic basis of antisocial behaviour, little progress has been made for antisocial personality disorder…”
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