Search Results - "PRZANOWSKI, Piotr"

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells by Ciechomska, Iwona Anna, Przanowski, Piotr, Jackl, Judyta, Wojtas, Bartosz, Kaminska, Bozena

“…Glioblastoma (GBM) contains rare glioma stem-like cells (GSCs) with capacities of self-renewal, multi-lineage differentiation, and resistance to conventional…”
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Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas by Sielska, Malgorzata, Przanowski, Piotr, Pasierbińska, Maria, Wojnicki, Kamil, Poleszak, Katarzyna, Wojtas, Bartosz, Grzeganek, Dominika, Ellert-Miklaszewska, Aleksandra, Ku, Min-Chi, Kettenmann, Helmut, Kaminska, Bozena

“…Background Malignant tumours release factors, which attract myeloid cells and induce their polarisation to pro-invasive, immunosuppressive phenotypes…”
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Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response by Sielska, Malgorzata, Przanowski, Piotr, Wylot, Bartosz, Gabrusiewicz, Konrad, Maleszewska, Marta, Kijewska, Magdalena, Zawadzka, Malgorzata, Kucharska, Joanna, Vinnakota, Katyayni, Kettenmann, Helmut, Kotulska, Katarzyna, Grajkowska, Wieslawa, Kaminska, Bozena

“…Gliomas attract brain‐resident (microglia) and peripheral macrophages and reprogram these cells into immunosuppressive, pro‐invasive cells. M‐CSF (macrophage…”
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Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors by Kim, Dae Joong, Anandh, Swetha, Null, Jamie L., Przanowski, Piotr, Bhatnagar, Sanchita, Kumar, Pankaj, Shelton, Sarah E., Grundy, Erin E., Chiappinelli, Katherine B., Kamm, Roger D., Barbie, David A., Dudley, Andrew C.

“…Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic activity, especially when paired with cancer immunotherapies. Here we…”
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ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation by Przanowski, Piotr, Przanowska, Róża K., Guertin, Michael J.

“…Alleles within the chr19p13.1 locus are associated with increased risk of both ovarian and breast cancer and increased expression of the ANKLE1 gene. ANKLE1 is…”
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ISG'ylation increases stability of numerous proteins including Stat1, which prevents premature termination of immune response in LPS-stimulated microglia by Przanowski, Piotr, Loska, Stefan, Cysewski, Dominik, Dabrowski, Michal, Kaminska, Bozena

“…Microglia are myeloid cells in the central nervous system which maintain homeostasis and contribute to repair, but instigate neuroinflammation when are…”
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The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia by Przanowski, Piotr, Dabrowski, Michal, Ellert-Miklaszewska, Aleksandra, Kloss, Michal, Mieczkowski, Jakub, Kaza, Beata, Ronowicz, Anna, Hu, Feng, Piotrowski, Arkadiusz, Kettenmann, Helmut, Komorowski, Jan, Kaminska, Bozena

“…Most neurological diseases are associated with chronic inflammation initiated by the activation of microglia, which produce cytotoxic and inflammatory factors…”
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Knockdown of STAT3 targets a subpopulation of invasive melanoma stem‐like cells by Kulesza, Dorota W, Przanowski, Piotr, Kaminska, Bozena

“…Transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers, including melanomas. Active,…”
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Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression by MUHAMMAD ZAEEM NOMAN, JANJI, Bassam, CHOUAIB, Salem, KAMINSKA, Bozena, MOER, Kris Van, PIERSON, Sandrine, PRZANOWSKI, Piotr, BUART, Stéphanie, BERCHEM, Guy, ROMERO, Pedro, MAMI-CHOUAIB, Fathia

“…The relationship between hypoxic stress, autophagy, and specific cell-mediated cytotoxicity remains unknown. This study shows that hypoxia-induced resistance…”
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Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer by Przanowski, Piotr, Lou, Song, Tihagam, Rachisan Djiake, Mondal, Tanmoy, Conlan, Caroline, Shivange, Gururaj, Saltani, Ilyas, Singh, Chandrajeet, Xing, Kun, Morris, Benjamin B, Mayo, Marty W, Teixeira, Luis, Lehmann-Che, Jacqueline, Tushir-Singh, Jogender, Bhatnagar, Sanchita

“…The majority of clinical deaths in patients with triple-negative breast cancer (TNBC) are due to chemoresistance and aggressive metastases, with high…”
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miR‐206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro by Przanowska, Roza K., Sobierajska, Ewelina, Su, Zhangli, Jensen, Kate, Przanowski, Piotr, Nagdas, Sarbajeet, Kashatus, Jennifer A., Kashatus, David F., Bhatnagar, Sanchita, Lukens, John R., Dutta, Anindya

“…miR‐206, miR‐1a‐1, and miR‐1a‐2 are induced during differentiation of skeletal myoblasts and promote myogenesis in vitro. miR‐206 is required for skeletal…”
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Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice by Przanowski, Piotr, Wasko, Urszula, Zheng, Zeming, Yu, Jun, Sherman, Robyn, Zhu, Lihua Julie, McConnell, Michael J., Tushir-Singh, Jogender, Green, Michael R., Bhatnagar, Sanchita

“…Rett syndrome (RTT) is a genetic disorder resulting from a loss-of-function mutation in one copy of the X-linked gene methyl-CpG–binding protein 2 (MECP2)…”
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Toxoplasma gondii infection supports the infiltration of T cells into brain tumors by Nguyen, Yen T.M., Sibley, Lydia, Przanowski, Piotr, Zhao, Xiao-Yu, Kovacs, Michael, Wang, Shengyuan, Jones, Marieke K., Cowan, Maureen, Liu, Wenjie, Merchak, Andrea R., Gaultier, Alban, Janes, Kevin, Zang, Chongzhi, Harris, Tajie, Ewald, Sarah E., Zong, Hui

“…Few T cells infiltrate into primary brain tumors, fundamentally hampering the effectiveness of immunotherapy. We hypothesized that Toxoplasma gondii, a…”
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Kinetic networks identify TWIST2 as a key regulatory node in adipogenesis by Dutta, Arun B, Lank, Daniel S, Przanowska, Roza K, Przanowski, Piotr, Wang, Lixin, Nguyen, Bao, Walavalkar, Ninad M, Duarte, Fabiana M, Guertin, Michael J

“…Adipocytes contribute to metabolic disorders such as obesity, diabetes, and atherosclerosis. Prior characterizations of the transcriptional network driving…”
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A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome by Przanowski, Piotr, Zheng, Zeming, Wasko, Urszula, Bhatnagar, Sanchita

“…X chromosome inactivation (XCI) is the random silencing of one X chromosome in females to achieve gene dosage balance between the sexes. As a result, all…”
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A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer by Shivange, Gururaj, Urbanek, Karol, Przanowski, Piotr, Perry, Justin S.A., Jones, James, Haggart, Robert, Kostka, Christina, Patki, Tejal, Stelow, Edward, Petrova, Yuliya, Llaneza, Danielle, Mayo, Marty, Ravichandran, Kodi S., Landen, Charles N., Bhatnagar, Sanchita, Tushir-Singh, Jogender

“…Therapeutic antibodies targeting ovarian cancer (OvCa)-enriched receptors have largely been disappointing due to limited tumor-specific antibody-dependent…”
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Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors by Przanowska, Roza K., Weidmann, Chase A., Saha, Shekhar, Cichewicz, Magdalena A., Jensen, Kate N., Przanowski, Piotr, Irving, Patrick S., Janes, Kevin A., Guertin, Michael J., Weeks, Kevin M., Dutta, Anindya

“…Many lncRNAs have been discovered using transcriptomic data; however, it is unclear what fraction of lncRNAs is functional and what structural properties…”
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Open chromatin landscape of rat microglia upon proinvasive or inflammatory polarization by Przanowski, Piotr, Mondal, Shamba S., Cabaj, Aleksandra, Dębski, Konrad J., Wojtas, Bartosz, Gielniewski, Bartłomiej, Kaza, Beata, Kaminska, Bozena, Dabrowski, Michal

“…Microglia are brain‐resident, myeloid cells that play important roles in health and brain pathologies. Herein, we report a comprehensive, replicated, false…”
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Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma by Mieczkowski, Jakub, Kocyk, Marta, Nauman, Pawel, Gabrusiewicz, Konrad, Sielska, Małgorzata, Przanowski, Piotr, Maleszewska, Marta, Rajan, Wenson D, Pszczolkowska, Dominika, Tykocki, Tomasz, Grajkowska, Wieslawa, Kotulska, Katarzyna, Roszkowski, Marcin, Kostkiewicz, Boguslaw, Kaminska, Bozena

“…Glioblastoma (GBM) is an aggressive malignancy associated with profound host immunosuppression. Microglia and macrophages infiltrating GBM acquire the…”
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Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells by Kruczyk, Marcin, Przanowski, Piotr, Dabrowski, Michal, Swiatek-Machado, Karolina, Mieczkowski, Jakub, Wallerman, Ola, Ronowicz, Anna, Piotrowski, Arkadiusz, Wadelius, Claes, Kaminska, Bozena, Komorowski, Jan

“…Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many human tumors, including gliomas, and regulates the expression of…”
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