Search Results - "PRUSS, R. M"

Phenotypic screening strategies for neurodegenerative diseases: a pathway to discover novel drug candidates and potential disease targets or mechanisms by Pruss, R M

“…Target-directed drug design, although a conceptually rational approach, is only one strategy for drug discovery. In the case of neurodegenerative diseases…”
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Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model by Sunyach, C., Michaud, M., Arnoux, T., Bernard-Marissal, N., Aebischer, J., Latyszenok, V., Gouarné, C., Raoul, C., Pruss, R.M., Bordet, T., Pettmann, B.

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. The pathology is mimicked to a striking degree in transgenic mice carrying familial…”
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Protective role of olesoxime against wild‐type α‐synuclein‐induced toxicity in human neuronally differentiated SHSY‐5Y cells by Gouarné, C, Tracz, J, Paoli, M Giraudon, Deluca, V, Seimandi, M, Tardif, G, Xilouri, M, Stefanis, L, Bordet, T, Pruss, R M

“…Background and Purpose Parkinson's disease (PD) is usually diagnosed clinically from classical motor symptoms, while definitive diagnosis is made postmortem,…”
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Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells by Pruss, R M, Akeson, R L, Racke, M M, Wilburn, J L

“…Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed…”
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Voltage-regulated calcium channels involved in the regulation of enkephalin synthesis are blocked by phorbol ester treatment by Pruss, R M, Stauderman, K A

“…Treatment of bovine chromaffin cells with 40 mM KCl stimulates a 3-fold increase in total methionine enkephalin immunoreactivity (medium plus cells) and a…”
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Variants of 3T3 Cells Lacking Mitogenic Response to Epidermal Growth Factor by Pruss, Rebecca M., Herschman, Harvey R.

“…We have previously demonstrated that epidermal growth factor (EGF) can serve as a potent mitogen for 3T3 cells. We have now selected variant 3T3 cell lines…”
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Selective regulation of carboxypeptidase peptide hormone-processing enzyme during enkephalin biosynthesis in cultured bovine adrenomedullary chromaffin cells by Hook, V Y, Eiden, L E, Pruss, R M

“…Bovine adrenomedullary chromaffin cells in culture were incubated with reserpine or forskolin, two agents acting through different mechanisms, which increase…”
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Human metabotropic glutamate receptor 1:mRNA distribution, chromosome localization and functional expression of two splice variants by STEPHAN, D, BON, C, HOLZWARTH, J. A, GALVAN, M, PRUSS, R. M

“…We have isolated clones from a human brain cDNA library coding for two splice variants of mGluR1. The combined sequences account for 6864 base pairs (bp) of…”
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Neuropeptide Y and peptide YY neuronal and endocrine systems by O'Donohue, T L, Chronwall, B M, Pruss, R M, Mezey, E, Kiss, J Z, Eiden, L E, Massari, V J, Tessel, R E, Pickel, V M, DiMaggio, D A

“…An extensive system of neuropeptide Y (NPY) containing neurons has recently been identified in the central and peripheral nervous system. In addition, NPY and…”
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Galanin gene expression in chromaffin cells is controlled by calcium and protein kinase signaling pathways by Rökaeus, A, Pruss, R M, Eiden, L E

“…The neuropeptide galanin (GAL) is widely distributed throughout the diffuse neuroendocrine system, and is coexpressed with acetylcholine, norepinephrine,…”
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Cytochrome b561 can be detected in many neuroendocrine tissues using a specific monoclonal antibody by Pruss, R M, Shepard, E A

“…CG7 is a monoclonal antibody that recognizes cytochrome b561, a major protein component of adrenal medullary chromaffin granules. Immunocytochemical studies…”
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Myelin-Specific Proteins and Glycolipids in Rat Schwann Cells and Oligodendrocytes in Culture by Mirsky, Rhona, Winter, Janet, Abney, Erika R., Pruss, Rebecca M., Gavrilovic, Jelena, Raff, Martin C.

“…We have used antibodies to identify Schwann cells and oligodendrocytes and to study the expression of myelin-specific glycolipids and proteins in these cells…”
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Immunochemical Characterization of Carboxypeptidase B-Like Peptide-Hormone-Processing Enzyme by Vivian Y. H. Hook, Mezey, Eva, Fricker, Lloyd D., Pruss, Rebecca M., Siegel, Ruth E., Brownstein, Michael J.

“…Specific rabbit antisera against purified bovine pituitary carboxypeptidase processing enzyme (which has also been referred to as ``enkephalin convertase'')…”
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Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells by Aharonov, A, Pruss, R M, Herschman, H R

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Monoclonal antibodies to chromaffin cells can distinguish proteins specific to or specifically excluded from chromaffin granules by Pruss, R M

“…I have prepared a number of monoclonal antibodies to chromaffin cell membranes. One of these antibodies recognizes a number of antigenically related proteins…”
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Specific Radiolabeling of a Cell Surface Receptor for Epidermal Growth Factor by Das, Manjusri, Miyakawa, Tokichi, Fox, C. Fred, Pruss, Rebecca M., Aharonov, Aharon, Herschman, Harvey R.

“…A photoreactive derivative of epidermal growth factor (EGF) has been used to identify and specifically label a membrane receptor for EGF on mouse 3T3 cells…”
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Dissociation of Ca2+ entry and Ca2+ mobilization responses to angiotensin II in bovine adrenal chromaffin cells by Stauderman, K A, Pruss, R M

“…In fura-2-loaded bovine adrenal chromaffin cells, 0.5 microM angiotensin II (AII) stimulated a 185 ± 19 nM increase of intracellular-free calcium [(Ca2+]i)…”
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Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results by Atar, Dan, Arheden, Håkan, Berdeaux, Alain, Bonnet, Jean-Louis, Carlsson, Marcus, Clemmensen, Peter, Cuvier, Valérie, Danchin, Nicolas, Dubois-Randé, Jean-Luc, Engblom, Henrik, Erlinge, David, Firat, Hüseyin, Halvorsen, Sigrun, Hansen, Henrik Steen, Hauke, Wilfried, Heiberg, Einar, Koul, Sasha, Larsen, Alf-Inge, Le Corvoisier, Philippe, Nordrehaug, Jan Erik, Paganelli, Franck, Pruss, Rebecca M, Rousseau, Hélène, Schaller, Sophie, Sonou, Giles, Tuseth, Vegard, Veys, Julien, Vicaut, Eric, Jensen, Svend Eggert

“…The MITOCARE study evaluated the efficacy and safety of TRO40303 for the reduction of reperfusion injury in patients undergoing revascularization for…”
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Multiple populations of neuropeptide-containing cells in cultures of the bovine adrenal medulla by Siegel, R E, Eiden, L E, Pruss, R M

“…Cell populations containing vasoactive intestinal polypeptide (VIP), enkephalins, and catecholamines were identified in bovine adrenal medullary cultures by…”
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Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells by Pruss, R M, Moskal, J R, Eiden, L E, Beinfeld, M C

“…Two neuropeptides, enkephalin and vasoactive intestinal polypeptide (VIP), are simultaneously increased in cultures of bovine chromaffin cells after diverse…”
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