Search Results - "PROTTER, A. A"

Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide by Cochrane, Dawn R, Bernales, Sebastián, Jacobsen, Britta M, Cittelly, Diana M, Howe, Erin N, D'Amato, Nicholas C, Spoelstra, Nicole S, Edgerton, Susan M, Jean, Annie, Guerrero, Javier, Gómez, Francisco, Medicherla, Satyanarayana, Alfaro, Iván E, McCullagh, Emma, Jedlicka, Paul, Torkko, Kathleen C, Thor, Ann D, Elias, Anthony D, Protter, Andrew A, Richer, Jennifer K

“…The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast…”
Get full text

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model by Steele, J W, Lachenmayer, M L, Ju, S, Stock, A, Liken, J, Kim, S H, Delgado, L M, Alfaro, I E, Bernales, S, Verdile, G, Bharadwaj, P, Gupta, V, Barr, R, Friss, A, Dolios, G, Wang, R, Ringe, D, Fraser, P, Westaway, D, St George-Hyslop, P H, Szabo, P, Relkin, N R, Buxbaum, J D, Glabe, C G, Protter, A A, Martins, R N, Ehrlich, M E, Petsko, G A, Yue, Z, Gandy, S

“…Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer's disease,…”
Get full text

Restricted Delivery of Talazoparib Across the Blood-Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma by Kizilbash, Sani H, Gupta, Shiv K, Chang, Kenneth, Kawashima, Ryo, Parrish, Karen E, Carlson, Brett L, Bakken, Katrina K, Mladek, Ann C, Schroeder, Mark A, Decker, Paul A, Kitange, Gaspar J, Shen, Yuqiao, Feng, Ying, Protter, Andrew A, Elmquist, William F, Sarkaria, Jann N

“…Poly ADP-ribose polymerase (PARP) inhibitors, including talazoparib, potentiate temozolomide efficacy in multiple tumor types; however, talazoparib-mediated…”
Get full text

Evidence for Functional Heterogeneity of Circulating B-Type Natriuretic Peptide by Liang, Faquan, MD, PhD, O’Rear, Jessica, Schellenberger, Ute, PhD, Tai, Lungkuo, PhD, Lasecki, Michael, Schreiner, George F., MD, PhD, Apple, Fred S., PhD, Maisel, Alan S., MD, Pollitt, N. Stephen, PhD, Protter, Andrew A., PhD

“…Evidence for Functional Heterogeneity of Circulating B-Type Natriuretic Peptide Faquan Liang, Jessica O’Rear, Ute Schellenberger, Lungkuo Tai, Michael Lasecki,…”
Get full text

Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses by Shen, Zhewei, Halberg, Anna, Fong, Jia Yi, Guo, Jingyu, Song, Gavin, Louie, Brent, Luedtke, Gregory R., Visuthikraisee, Viwat, Protter, Andrew A., Koh, Xiaoying, Baik, Taegon, Lum, Pek Yee

“…COVID-19, first reported in late 2019, is an ongoing pandemic that has been causing devastation across the globe. Although there are multiple vaccines that can…”
Get full text

Activation of p38 mitogen‐activated protein kinase in spinal microglia is a critical link in inflammation‐induced spinal pain processing by Svensson, Camilla I., Marsala, Martin, Westerlund, Anna, Calcutt, Nigel A., Campana, Wendy M., Freshwater, Jason D., Catalano, Rosanne, Feng, Ying, Protter, Andrew A., Scott, Brian, Yaksh, Tony L.

“…We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models of nociception and correlated this effect with localization and…”
Get full text

Altered Patterns of Gene Expression in Response to Myocardial Infarction by Stanton, Lawrence W, Garrard, Lisa J, Damm, Deborah, Garrick, Brett L, Lam, Andrew, Kapoun, Ann M, Zheng, Qiang, Protter, Andrew A, Schreiner, George F, White, R Tyler

“…The use of cDNA microarrays has made it possible to simultaneously analyze gene expression for thousands of genes. Microarray technology was used to evaluate…”
Get full text

Recombinant Vascular Endothelial Growth Factor 121 Attenuates Hypertension and Improves Kidney Damage in a Rat Model of Preeclampsia by Li, Zhihe, Zhang, Ying, Ma, Jing Ying, Kapoun, Ann M, Shao, Qiming, Kerr, Irene, Lam, Andrew, O’Young, Gilbert, Sannajust, Frederick, Stathis, Peter, Schreiner, George, Karumanchi, S Ananth, Protter, Andrew A, Pollitt, N Stephen

“…Inhibitors of angiogenic factors are known to be upregulated, and their levels increase in the maternal circulation before the onset of preeclampsia. We…”
Get full text

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain by Steele, J W, Ju, S, Lachenmayer, M L, Liken, J, Stock, A, Kim, S H, Delgado, L M, Alfaro, I E, Bernales, S, Verdile, G, Bharadwaj, P, Gupta, V, Barr, R, Friss, A, Dolios, G, Wang, R, Ringe, D, Protter, A A, Martins, R N, Ehrlich, M E, Yue, Z, Petsko, G A, Gandy, S

“…Latrepirdine (Dimebon; dimebolin) is a neuroactive compound that was associated with enhanced cognition, neuroprotection and neurogenesis in laboratory…”
Get full text

B-Type Natriuretic Peptide Exerts Broad Functional Opposition to Transforming Growth Factor-β in Primary Human Cardiac Fibroblasts: Fibrosis, Myofibroblast Conversion, Proliferation, and Inflammation by Kapoun, Ann M, Liang, Faquan, O’Young, Gilbert, Damm, Deborah L, Quon, Diana, White, R Tyler, Munson, Kimberly, Lam, Andrew, Schreiner, George F, Protter, Andrew A

“…ABSTRACT—The natriuretic peptides, including human B-type natriuretic peptide (BNP), have been implicated in the regulation of cardiac remodeling. Because…”
Get full text

Progressive transforming growth factor β1-induced lung fibrosis is blocked by an orally active alk5 kinase inhibitor by BONNIAUD, Philippe, MARGETTS, Peter J, PROTTER, Andrew A, GAULDIE, Jack, KOLB, Martin, SCHROEDER, Jane Ann, KAPOUN, Ann M, DAMM, Debby, MURPHY, Alison, CHAKRAVARTY, Sarvajit, DUGAR, Sundeep, HIGGINS, Linda

Get full text

CD36 is a receptor for oxidized low density lipoprotein by ENDEMANN, G, STANTON, L. W, MADDEN, K. S, BRYANT, C. M, WHITE, R. T, PROTTER, A. A

“…The oxidation of low density lipoprotein (LDL) in the arterial wall is thought to contribute to human atherosclerotic lesion formation, in part by the high…”
Get full text

The precursor to B-type natriuretic peptide is an O-linked glycoprotein by Schellenberger, Ute, O’Rear, Jessica, Guzzetta, Andrew, Jue, Rodney A., Protter, Andrew A., Stephen Pollitt, N.

“…Human pro-B-type natriuretic peptide (proBNP), the precursor for B-type natriuretic peptide (BNP), was expressed in Chinese hamster ovary cells (CHO) and…”
Get full text

Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE2 release and thermal hyperalgesia by Svensson, Camilla I, Hua, Xiao-Ying, Protter, Andrew A, Powell, Henry C, Yaksh, Tony L

“…Based on previous work, we hypothesized that activation of spinal NMDA-receptor initiates activation of the p38 mitogen-activated protein kinase (p38 MAPK)…”
Get full text

Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia by Sweitzer, S.M., Peters, M.C., Ma, J.Y., Kerr, I., Mangadu, R., Chakravarty, S., Dugar, S., Medicherla, S., Protter, A.A., Yeomans, D.C.

“…The stress-activated mitogen-activated protein kinase (MAPK) p38 is emerging as an important mediator of pain. The present study examined the possible…”
Get full text

Inhibition of p38α MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-XL, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo by Navas, T A, Nguyen, A N, Hideshima, T, Reddy, M, Ma, J Y, Haghnazari, E, Henson, M, Stebbins, E G, Kerr, I, O'Young, G, Kapoun, A M, Chakravarty, S, Mavunkel, B, Perumattam, J, Luedtke, G, Dugar, S, Medicherla, S, Protter, A A, Schreiner, G F, Anderson, K C, Higgins, L S

“…Inhibition of p38 kinase blocks the production of tumor-promoting factors in the multiple myeloma (MM) bone marrow microenvironment. Proteasome inhibitors…”
Get full text

B-Type Natriuretic Peptide Inhibited Angiotensin II-Stimulated Cholesterol Biosynthesis, Cholesterol Transfer, and Steroidogenesis in Primary Human Adrenocortical Cells by Liang, Faquan, Kapoun, Ann M, Lam, Andrew, Damm, Debby L, Quan, Diana, O’Connell, Maile, Protter, Andrew A

“…In this study, we demonstrate that B-type natriuretic peptide (BNP) opposed angiotensin II (Ang II)-stimulated de novo cholesterol biosynthesis, cellular…”
Get full text

Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction by LUCHNER, A, MUDERS, F, DIETL, O, FRIEDRICH, E, BLUMBERG, F, PROTTER, A. A, RIEGGER, G. A. J, ELSNER, D

“…Activation of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) is considered a hallmark of myocardial remodeling. To determine magnitude…”
Get full text

Antinociceptive action of a p38α MAPK inhibitor, SD-282, in a diabetic neuropathy model by Sweitzer, Sarah M., Medicherla, Satyanarayana, Almirez, Ramona, Dugar, Sundeep, Chakravarty, Sarvajit, Shumilla, Jennifer A., Yeomans, David C., Protter, Andrew A.

“…Diabetes can induce a bewildering list of sensory changes, including alteration in pain sensitivity. Painful diabetic neuropathy is refractory to most common…”
Get full text

Clinical Implications of Defective B‐Type Natriuretic Peptide by Menon, Santosh G., Mills, Roger M., Schellenberger, Ute, Saqhir, Syed, Protter, Andrew A.

“…Our understanding of the natriuretic peptide system continues to evolve rapidly. B‐type natriuretic peptide (BNP), originally thought to be a simple…”
Get full text