Search Results - "PROCHAZKA, JAN"

Towards a Cure for Diamond-Blackfan Anemia: Views on Gene Therapy by Vale, Matilde, Prochazka, Jan, Sedlacek, Radislav

“…Diamond-Blackfan anemia (DBA) is a rare genetic disorder affecting the bone marrow's ability to produce red blood cells, leading to severe anemia and various…”
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Different approaches to superhard coatings and nanocomposites by Veprek, Stan, Veprek-Heijman, Maritza G.J., Karvankova, Pavla, Prochazka, Jan

“…Different approaches to the preparation of superhard coatings such as intrinsically superhard materials, coatings whose hardness is enhanced by energetic ion…”
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Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland by Nedvetsky, Pavel I., Emmerson, Elaine, Finley, Jennifer K., Ettinger, Andreas, Cruz-Pacheco, Noel, Prochazka, Jan, Haddox, Candace L., Northrup, Emily, Hodges, Craig, Mostov, Keith E., Hoffman, Matthew P., Knox, Sarah M.

“…A fundamental question in development is how cells assemble to form a tubular network during organ formation. In glandular organs, tubulogenesis is a multistep…”
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TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases by Ujevic, Andrea, Knizkova, Daniela, Synackova, Alzbeta, Pribikova, Michaela, Trivic, Tijana, Dalinskaya, Anna, Drobek, Ales, Niederlova, Veronika, Paprckova, Darina, De Guia, Roldan, Kasparek, Petr, Prochazka, Jan, Labaj, Juraj, Fedosieieva, Olha, Roeck, Bernhard Florian, Mihola, Ondrej, Trachtulec, Zdenek, Sedlacek, Radislav, Stepanek, Ondrej, Draber, Peter

“…The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we show that the two adapter proteins, TANK and AZI2, suppress…”
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Proteolytic profiles of two isoforms of human AMBN expressed in E. coli by MMP-20 and KLK-4 proteases by Vetyskova, Veronika, Hubalek, Martin, Sulc, Josef, Prochazka, Jan, Vondrasek, Jiri, Vydra Bousova, Kristyna

“…Ameloblastin is a protein in biomineralization of tooth enamel. However recent results indicate that this is probably not its only role in an organism. Enamel…”
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Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer by Kasikova, Lenka, Rakova, Jana, Hensler, Michal, Lanickova, Tereza, Tomankova, Jana, Pasulka, Josef, Drozenova, Jana, Mojzisova, Katerina, Fialova, Anna, Vosahlikova, Sarka, Laco, Jan, Ryska, Ales, Dundr, Pavel, Kocian, Roman, Brtnicky, Tomas, Skapa, Petr, Capkova, Linda, Kovar, Marek, Prochazka, Jan, Praznovec, Ivan, Koblizek, Vladimir, Taskova, Alice, Tanaka, Hisashi, Lischke, Robert, Mendez, Fernando Casas, Vachtenheim, Jiri, Heinzelmann-Schwarz, Viola, Jacob, Francis, McNeish, Iain A., Halaska, Michal J., Rob, Lukas, Cibula, David, Orsulic, Sandra, Galluzzi, Lorenzo, Spisek, Radek, Fucikova, Jitka

“…Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their…”
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Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development by Prochazkova, Michaela, Prochazka, Jan, Marangoni, Pauline, Klein, Ophir D

“…Members of the fibroblast growth factor (FGF) family have myriad functions during development of both non-vertebrate and vertebrate organisms. One of these…”
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Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions by Spoutil, Frantisek, Aranaz-Novaliches, Goretti, Prochazkova, Michaela, Wald, Tomas, Novosadova, Vendula, Kasparek, Petr, Osicka, Radim, Reseland, Janne E., Lyngstadaas, Staale P., Tiainen, Hanna, Bousova, Kristyna, Vondrasek, Jiri, Sedlacek, Radislav, Prochazka, Jan

“…Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial…”
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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation by Sinigaglia, Ketty, Cherian, Anna, Du, Qiupei, Lacovich, Valentina, Vukić, Dragana, Melicherová, Janka, Linhartova, Pavla, Zerad, Lisa, Stejskal, Stanislav, Malik, Radek, Prochazka, Jan, Bondurand, Nadège, Sedláček, Radislav, O’Connell, Mary A., Keegan, Liam P.

“…Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon…”
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Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients by Holicek, Peter, Truxova, Iva, Rakova, Jana, Salek, Cyril, Hensler, Michal, Kovar, Marek, Reinis, Milan, Mikyskova, Romana, Pasulka, Josef, Vosahlikova, Sarka, Remesova, Hana, Valentova, Iva, Lysak, Daniel, Holubova, Monika, Kaspar, Petr, Prochazka, Jan, Kasikova, Lenka, Spisek, Radek, Galluzzi, Lorenzo, Fucikova, Jitka

“…While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust type I…”
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Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver by Aich, Abhishek, Boshnakovska, Angela, Witte, Steffen, Gall, Tanja, Unthan-Fechner, Kerstin, Yousefi, Roya, Chowdhury, Arpita, Dahal, Drishan, Methi, Aditi, Kaufmann, Svenja, Silbern, Ivan, Prochazka, Jan, Nichtova, Zuzana, Palkova, Marcela, Raishbrook, Miles, Koubkova, Gizela, Sedlacek, Radislav, Tröder, Simon E., Zevnik, Branko, Riedel, Dietmar, Michanski, Susann, Möbius, Wiebke, Ströbel, Philipp, Lüchtenborg, Christian, Giavalisco, Patrick, Urlaub, Henning, Fischer, Andre, Brügger, Britta, Jakobs, Stefan, Rehling, Peter

“…Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific…”
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Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis by Prochazka, Jan, Prochazkova, Michaela, Du, Wen, Spoutil, Frantisek, Tureckova, Jolana, Hoch, Renee, Shimogori, Tomomi, Sedlacek, Radislav, Rubenstein, John L., Wittmann, Torsten, Klein, Ophir D.

“…The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth…”
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Cytoplasmic polyadenylation by TENT5A is required for proper bone formation by Gewartowska, Olga, Aranaz-Novaliches, Goretti, Krawczyk, Paweł S., Mroczek, Seweryn, Kusio-Kobiałka, Monika, Tarkowski, Bartosz, Spoutil, Frantisek, Benada, Oldrich, Kofroňová, Olga, Szwedziak, Piotr, Cysewski, Dominik, Gruchota, Jakub, Szpila, Marcin, Chlebowski, Aleksander, Sedlacek, Radislav, Prochazka, Jan, Dziembowski, Andrzej

“…Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals…”
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Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice by Vacurova, Eliska, Trnovska, Jaroslava, Svoboda, Petr, Skop, Vojtech, Novosadova, Vendula, Reguera, David Pajuelo, Petrezselyová, Silvia, Piavaux, Benoit, Endaya, Berwini, Spoutil, Frantisek, Zudova, Dagmar, Stursa, Jan, Melcova, Magdalena, Bielcikova, Zuzana, Werner, Lukas, Prochazka, Jan, Sedlacek, Radislav, Huttl, Martina, Hubackova, Sona Stemberkova, Haluzik, Martin, Neuzil, Jiri

“…Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search…”
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Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome by Chowdhury, Arpita, Boshnakovska, Angela, Aich, Abhishek, Methi, Aditi, Vergel Leon, Ana Maria, Silbern, Ivan, Lüchtenborg, Christian, Cyganek, Lukas, Prochazka, Jan, Sedlacek, Radislav, Lindovsky, Jiri, Wachs, Dominic, Nichtova, Zuzana, Zudova, Dagmar, Koubkova, Gizela, Fischer, André, Urlaub, Henning, Brügger, Britta, Katschinski, Dörthe M, Dudek, Jan, Rehling, Peter

“…Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS) is a severe disorder, due to dysfunction of the mitochondrial…”
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Influence of Machine Tool Operating Conditions on the Resulting Circularity and Positioning Accuracy by Sarvas, Matej, Holub, Michal, Marek, Tomas, Prochazka, Jan, Bradac, Frantisek, Blecha, Petr

“…The operating conditions of the production process significantly influence the resulting dimensional and form accuracy of the workpiece. The operating…”
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Skeletal dysmorphology and mineralization defects in Fgf20 KO mice by Dlugosova, Sylvie, Spoutil, Frantisek, Madureira Trufen, Carlos Eduardo, Melike Ogan, Betul, Prochazkova, Michaela, Fedosieieva, Olha, Nickl, Petr, Aranaz Novaliches, Goretti, Sedlacek, Radislav, Prochazka, Jan

“…Fibroblast growth factor 20 (Fgf20), a member of the Fgf9 subfamily, was identified as an important regulator of bone differentiation and homeostasis…”
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Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns by Iatsiuk, Veronika, Malinka, Frantisek, Pickova, Marketa, Tureckova, Jolana, Klema, Jiri, Spoutil, Frantisek, Novosadova, Vendula, Prochazka, Jan, Sedlacek, Radislav

“…Ubiquitin ligases (Ub-ligases) are essential intracellular enzymes responsible for the regulation of proteome homeostasis, signaling pathway crosstalk, cell…”
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Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation by Pavliuchenko, Nataliia, Duric, Iris, Kralova, Jarmila, Fabisik, Matej, Spoutil, Frantisek, Prochazka, Jan, Kasparek, Petr, Pokorna, Jana, Skopcova, Tereza, Sedlacek, Radislav, Brdicka, Tomas

“…Autoinflammatory diseases are characterized by dysregulation of innate immune system leading to spontaneous sterile inflammation. One of the well-established…”
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c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells by Kaspar, Petr, Prochazka, Jan, Efenberkova, Michaela, Juhasz, Attila, Novosadova, Vendula, Sedlacek, Radislav

“…Rhabdomyosarcomas (RMS) are a heterogeneous group of mesodermal tumors, the most common sub-types are embryonal (eRMS) and alveolar (aRMS) rhabdomyosarcoma…”
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