Search Results - "PROCACCIO, V"

Correlation between genetic polymorphisms and stroke recovery: Analysis of the GAIN Americas and GAIN International Studies by Cramer, S. C., Procaccio, V.

“…Background and purpose:  Recovery after stroke occurs on the basis of specific molecular events. Genetic polymorphisms associated with impaired neural repair…”
Get full text

The mitochondrial DNA content of cumulus granulosa cells is linked to embryo quality by Desquiret-Dumas, V., Clément, A., Seegers, V., Boucret, L., Ferré-L'Hotellier, V., Bouet, P.E., Descamps, P., Procaccio, V., Reynier, P., May-Panloup, P.

“…Abstract STUDY QUESTION Could the mitochondrial DNA (mtDNA) content of cumulus granulosa cells (CGCs) be related to oocyte competence? SUMMARY ANSWER The…”
Get full text

Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells by Boucret, L., Chao de la Barca, J.M., Morinière, C., Desquiret, V., Ferré-L'Hôtellier, V., Descamps, P., Marcaillou, C., Reynier, P., Procaccio, V., May-Panloup, P.

“…STUDY QUESTION What part do mitochondria play in cases of diminished ovarian reserve (DOR)? SUMMARY ANSWER Mitochondrial biogenesis in cumulus cells may be…”
Get full text

Highly asymmetrical distribution of muscle wasting correlates to the heteroplasmy in a patient carrying a large-scale mitochondrial DNA deletion: a novel pathophysiological mechanism for explaining asymmetry in mitochondrial myopathies by Masingue, M., Rucheton, B., Bris, C., Romero, N.B., Procaccio, V., Eymard, B

“…•Heteroplasmy varies not only in different organs but within different muscles•heteroplasmy explains asymmetrical muscle involvement in mitochondrial…”
Get full text

The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy 'plus' phenotype by Rouzier, Cécile, Bannwarth, Sylvie, Chaussenot, Annabelle, Chevrollier, Arnaud, Verschueren, Annie, Bonello-Palot, Nathalie, Fragaki, Konstantina, Cano, Aline, Pouget, Jean, Pellissier, Jean-François, Procaccio, Vincent, Chabrol, Brigitte, Paquis-Flucklinger, Véronique

“…MFN2 and OPA1 genes encode two dynamin-like GTPase proteins involved in the fusion of the mitochondrial membrane. They have been associated with…”
Get full text

Deep sequencing shows that oocytes are not prone to accumulate mtDNA heteroplasmic mutations during ovarian ageing by Boucret, L., Bris, C., Seegers, V., Goudenège, D., Desquiret-Dumas, V., Domin-Bernhard, M., Ferré-L'Hotellier, V., Bouet, P.E., Descamps, P., Reynier, P., Procaccio, V., May-Panloup, P.

“…Abstract STUDY QUESTION Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER Our…”
Get full text

Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases by Koene, S., Rodenburg, R. J., van der Knaap, M. S., Willemsen, M. A. A. P., Sperl, W., Laugel, V., Ostergaard, E., Tarnopolsky, M., Martin, M. A., Nesbitt, V., Fletcher, J., Edvardson, S., Procaccio, V., Slama, A., van den Heuvel, L. P. W. J., Smeitink, J. A. M.

“…Mitochondrial complex I is the largest multi-protein enzyme complex of the oxidative phosphorylation system. Seven subunits of this complex are encoded by the…”
Get full text

Targeted metabolomics reveals reduced levels of polyunsaturated choline plasmalogens and a smaller dimethylarginine/arginine ratio in the follicular fluid of patients with a diminished ovarian reserve by de la Barca, J M Chao, Boueilh, T, Simard, G, Boucret, L, Ferré-L’Hotellier, V, Tessier, L, Gadras, C, Bouet, P E, Descamps, P, Procaccio, V, Reynier, P, May-Panloup, P

“…ABSTRACT STUDY QUESTION Does the metabolomic profile of the follicular fluid (FF) of patients with a diminished ovarian reserve (DOR) differ from that of…”
Get full text

The mitochondrial DNA content of cumulus cells may help predict embryo implantation by Taugourdeau, A., Desquiret-Dumas, V., Hamel, J. F., Chupin, S., Boucret, L., Ferré-L’Hotellier, V., Bouet, P. E., Descamps, P., Procaccio, V., Reynier, P., May-Panloup, P.

“…Purpose The quantification of mtDNA in cumulus granulosa cells (CGCs) surrounding an oocyte has been positively linked with morphological embryonic quality. In…”
Get full text

Perspectives of drug-based neuroprotection targeting mitochondria by Procaccio, V., Bris, C., Chao de la Barca, J.M., Oca, F., Chevrollier, A., Amati-Bonneau, P., Bonneau, D., Reynier, P.

“…Mitochondrial dysfunction has been reported in most neurodegenerative diseases. These anomalies include bioenergetic defect, respiratory chain-induced…”
Get full text

Mitochondrial complex I defect resulting from exercise-induced lower-limb ischemia in patients with peripheral arterial disease by Signolet, Isabelle, Abraham, Pierre, Chupin, Stéphanie, Ammi, Myriam, Gueguen, Naïg, Letournel, Franck, Picquet, Jean, Baufreton, Christophe, Daligault, Mickael, Procaccio, Vincent, Reynier, Pascal, Henni, Samir

“…This study aims to compare the structural and mitochondrial alterations between muscle segments affected by exercise-induced ischemia and segments of the same…”
Get full text

Key Role of Estrogens and Endothelial Estrogen Receptor α in Blood Flow–Mediated Remodeling of Resistance Arteries by Tarhouni, K, Guihot, A L, Freidja, M L, Toutain, B, Henrion, B, Baufreton, C, Pinaud, F, Procaccio, V, Grimaud, L, Ayer, A, Loufrani, L, Lenfant, F, Arnal, J F, Henrion, D

“…OBJECTIVE—Flow- (shear stress–)mediated outward remodeling of resistance arteries is involved in collateral growth during postischemic revascularization. As…”
Get full text

Multiethnic involvement in autosomal-dominant optic atrophy in Singapore by Loo, J L, Singhal, S, Rukmini, A V, Tow, S, Amati-Bonneau, P, Procaccio, V, Bonneau, D, Gooley, J J, Reynier, P, Ferré, M, Milea, D

“…Purpose Autosomal-dominant optic atrophy (ADOA), often associated with mutations in the OPA1 gene (chromosome 3q28-q29) is rarely reported in Asia. Our aim was…”
Get full text

Estrogens are needed for the improvement in endothelium-mediated dilation induced by a chronic increase in blood flow in rat mesenteric arteries by Tarhouni, K, Guihot, A.L, Vessieres, E, Procaccio, V, Grimaud, L, Abraham, P, Lenfant, F, Arnal, J.F, Favre, J, Loufrani, L, Henrion, D

“…Abstract Resistance arteries play a key role in the control of local blood flow. They undergo outward remodeling in response to a chronic increase in blood…”
Get full text

Early‐onset Behr syndrome due to compound heterozygous mutations in OPA1 by Bonneau, D., Lenaers, G., Procaccio, V., Amati‐Bonneau, P., Reynier, P.

“…Summary Behr syndrome is an early‐onset and severe syndromic optic atrophy which is probably heterogeneous. Recently, a heterozygous mutation in OPA1 was…”
Get full text

Deep Sequencing Shows That Oocytes Are Not Prone to Accumulate mtDNA Heteroplasmic Mutations During Ovarian Ageing by Boucret, L, Bris, C, Seegers, V, Goudenège, D, Desquiret-Dumas, V, Domin-Bernhard, M, Ferré-L’Hotellier, V, Bouet, P E, Descamps, P, Reynier, P, Procaccio, V, May-Panloup, P

“…(Abstracted from Hum Reprod 2017;32(10):2101–2109)This study looks at the effect of ovarian aging on the number of point mutations in oocyte mitochondrial DNA…”
Get full text

SIMULTANEOUS MFN2 AND GDAP1 MUTATIONS CAUSE MAJOR MITOCHONDRIAL DEFECTS IN A PATIENT WITH CMT by CASSEREAU, J, CASASNOVAS, C, PROCACCIO, V, CHEVROLLIER, A, GUEGUEN, N, MALINGE, M.-C, GUILLET, V, REYNIER, P, BONNEAU, D, AMATI-BONNEAU, P, BANCHS, I, VOLPINI, V

Get full text

Novel pathophysiological mechanisms in dominant optic atrophy beyond the mitochondrial dynamics equilibrium by Lenaers, G., Charif, M., Amati‐Bonneau, P., la Barca, J. Chao, Procaccio, V., Chevrollier, A., Leruez, S., Bonneau, D., Reynier, P.

“…Summary Inherited Optic Neuropathies are blinding diseases related to mitochondrial dysfunctions in retinal ganglion cell (RGC). There are two main forms: the…”
Get full text

The genetic pathophysiology of dominant optic atrophy by Lenaers, G., Charif, M., Amati‐Bonneau, P., Chao de la Barca, J., Procaccio, V., Gerber, S., Kaplan, J., Roubertie, A., Meunier, I., Reynier, P., Rozet, J.M., Hamel, C., Bonneau, D.

“…Summary Inherited Optic Neuropathies are blinding diseases related to mitochondrial dysfunctions jeopardizing retinal ganglion cell (RGC) survival. There are…”
Get full text

Identification of novel mutations in WFS1 and genotype-phenotype correlation in Wolfram syndrome by Cano, A., Rouzier, C., Monnot, S., Chabrol, B., Conrath, J., Lecomte, P., Delobel, B., Boileau, P., Valero, R., Procaccio, V., Paquis-Flucklinger, V., Vialettes, B.

“…Mutations in the WFS1 gene have been reported in Wolfram syndrome (WS), an autosomal recessive disorder defined by early onset of diabetes mellitus (DM) and…”
Get full text