Search Results - "PRIVETTE, Lisa M"

Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers by Singh, Navneet, Romick-Rosendale, Lindsey, Watanabe-Chailland, Miki, Privette Vinnedge, Lisa M, Komurov, Kakajan

“…Oncogenic kinase inhibitors show short-lived responses in the clinic due to high rate of acquired resistance. We previously showed that pharmacologically…”
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The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia by Wilcher, Katherine E., Page, Evan R.H., Privette Vinnedge, Lisa M.

“…•DEK-NUP214 is an oncogenic fusion protein in t(6;9) acute myeloid leukemia.•Nonfusion DEK protein supports hematopoietic stem cell maintenance and engraftment…”
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Stacking the DEK: From chromatin topology to cancer stem cells by Privette Vinnedge, Lisa M., Kappes, Ferdinand, Nassar, Nicolas, Wells, Susanne I.

“…Stem cells are essential for development and tissue maintenance and display molecular markers and functions distinct from those of differentiated cell types in…”
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DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages by Pease, Nicholas A., Shephard, Miranda S., Sertorio, Mathieu, Waltz, Susan E., Vinnedge, Lisa M. Privette

“…Breast cancer (BC) is the second leading cause of cancer deaths among women. DEK is a known oncoprotein that is highly expressed in over 60% of breast cancers…”
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The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer by Privette Vinnedge, Lisa M, Ho, Shuk-Mei, Wikenheiser-Brokamp, Kathryn A, Wells, Susanne I

“…Expression of estrogen and progesterone hormone receptors indicates a favorable prognosis due to the successful use of hormonal therapies such as tamoxifen and…”
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Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis by Greene, Allie N, Solomon, Matia B, Privette Vinnedge, Lisa M

“…Alzheimer's disease and age-related dementias (AD/ADRD) are debilitating diseases that exact a significant physical, emotional, cognitive, and financial toll…”
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In silico gene expression and pathway analysis of DEK in the human brain across the lifespan by Greene, Allie N., Nguyen, Elizabeth T., Paranjpe, Aditi, Lane, Adam, Privette Vinnedge, Lisa M., Solomon, Matia B.

“…DEK, a chromatin‐remodelling phosphoprotein, is associated with various functions and biological pathways in the periphery, including inflammation,…”
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Up-regulation of SEPT9_v1 stabilizes c-Jun-N-Terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells by Gonzalez, Maria E., Makarova, Olga, Peterson, Esther A., Privette, Lisa M., Petty, Elizabeth M.

“…SEPT9_v1, the largest transcript of the septin gene family member, SEPT9, encodes a septin isoform implicated in the tumorigenic transformation of mammary…”
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Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia by O'Donovan, Sinead M., Franco-Villanueva, Ana, Ghisays, Valentina, Caldwell, Jody L., Haroutunian, Vahraim, Privette Vinnedge, Lisa M., McCullumsmith, Robert E., Solomon, Matia B.

“…DEK is a chromatin-remodeling phosphoprotein found in most human tissues, but its expression and function in the human brain is largely unknown. DEK depletion…”
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Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells by Greene, Allie N, Parks, Lois G, Solomon, Matia B, Privette Vinnedge, Lisa M

“…Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This…”
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Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers : Implications for tumor suppression by PRIVETTE, Lisa M, GONZALEZ, Maria E, LEI DING, KLEER, Celina G, PETTY, Elizabeth M

“…Checkpoint with FHA and Ring Finger (CHFR) is hypothesized to mediate a delay in cell cycle progression early in mitosis in response to microtubule stress,…”
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Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling by Romick-Rosendale, Lindsey E, Hoskins, Elizabeth E, Privette Vinnedge, Lisa M, Foglesong, Grant D, Brusadelli, Marion G, Potter, S Steven, Komurov, Kakajan, Brugmann, Samantha A, Lambert, Paul F, Kimple, Randall J, Virts, Elizabeth L, Hanenberg, Helmut, Gillison, Maura L, Wells, Susanne I

“…Head and neck squamous cell carcinoma (HNSCC) remains a devastating disease, and Fanconi anemia (FA) gene mutations and transcriptional repression are common…”
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Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors by Serrano-Lopez, Juana, Nattamai, Kalpana, Pease, Nicholas A., Shephard, Miranda S., Wellendorf, Ashley M., Sertorio, Mathieu, Smith, Eric A., Geiger, Hartmut, Wells, Susanne I., Cancelas, Jose A., Privette Vinnedge, Lisa M.

“…•DEK loss causes restricted hematopoietic progenitor cells (HPCs) to enter quiescence (G0) in response to radiation.•DEK's role in radiation response is…”
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CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis by Privette, Lisa M., Petty, Elizabeth M.

“…Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to…”
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Loss of CHFR in Human Mammary Epithelial Cells Causes Genomic Instability by Disrupting the Mitotic Spindle Assembly Checkpoint by Privette, Lisa M., Weier, Jingly Fung, Nguyen, Ha Nam, Yu, Xiaochun, Petty, Elizabeth M.

“…CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability. To analyze the…”
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DEK is required for homologous recombination repair of DNA breaks by Smith, Eric A., Gole, Boris, Willis, Nicholas A., Soria, Rebeca, Starnes, Linda M., Krumpelbeck, Eric F., Jegga, Anil G., Ali, Abdullah M., Guo, Haihong, Meetei, Amom R., Andreassen, Paul R., Kappes, Ferdinand, Vinnedge, Lisa M. Privette, Daniel, Jeremy A., Scully, Ralph, Wiesmüller, Lisa, Wells, Susanne I.

“…DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces…”
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High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes by GONZALEZ, Maria E, PETERSON, Esther A, PRIVETTE, Lisa M, LOFFREDA-WREN, Janice L, KALIKIN, Linda M, PETTY, Elizabeth M

“…Altered expression of the human septin gene, SEPT9, and its murine homologue, Sept9, has been implicated in neoplasia. However, their role(s) in oncogenesis…”
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Abstract 2836: Expression of the DEK oncogene in breast cancer cells promotes M2 polarization of tumor associated macrophages by Shephard, Miranda, Pease, Nicholas, Vinnedge, Lisa M. Privette

“…Abstract Breast cancer is the second leading cause of cancer deaths among women. DEK is a known oncoprotein found to be highly expressed in more than 60%…”
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Abstract 3594: DEK overexpression in breast epithelial tissue creates a pro-oncogenic environment by Johnstone, Megan, Cheek, Jon, Vinnedge, Lisa M. Privette

“…Abstract Dense epithelial breast tissue, as detected by mammography, is correlated with a four- to six-fold increased risk for developing breast cancer (BC)…”
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Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers by Navneet Singh, Lindsey Romick-Rosendale, Miki Watanabe-Chailland, Lisa M. Privette Vinnedge, Kakajan Komurov

“…Oncogenic kinase inhibitors show short-lived responses in the clinic due to high rate of acquired resistance. We previously showed that pharmacologically…”
Get full text