Search Results - "PRITZKER, Kenneth"

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care by Pritzker, Kenneth P H, Nieminen, Heikki J

“…Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming even more important as precision medicine develops. However, the capability…”
Get full text

Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography by Karhula, Sakari S, Finnilä, Mikko A, Lammi, Mikko J, Ylärinne, Janne H, Kauppinen, Sami, Rieppo, Lassi, Pritzker, Kenneth P H, Nieminen, Heikki J, Saarakkala, Simo

“…Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular…”
Get full text

The role of LCN2 and LCN2-MMP9 in spondylitis radiographic development: gender and HLA-B27 status differences by Tsui, Florence W. L, Lin, Aifeng, Sari, Ismail, Zhang, Zhenbo, Pritzker, Kenneth P. H, Tsui, Hing Wo, Inman, Robert D

“…Background Male HLA-B27-positive radiographic-axial spondyloarthritis (r-axSpA) patients are prone to have severe spinal radiographic progression, but the…”
Get full text

Ultrasonic actuation of a fine-needle improves biopsy yield by Perra, Emanuele, Lampsijärvi, Eetu, Barreto, Gonçalo, Arif, Muhammad, Puranen, Tuomas, Hæggström, Edward, Pritzker, Kenneth P. H., Nieminen, Heikki J.

“…Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the…”
Get full text

An ultrasonically actuated needle promotes the transport of nanoparticles and fluids by Perra, Emanuele, Hayward, Nick, Pritzker, Kenneth P. H., Nieminen, Heikki J.

“…Non-invasive therapeutic ultrasound (US) methods, such as high-intensity focused ultrasound (HIFU), have limited access to tissue targets shadowed by bones or…”
Get full text

An ultrasonically actuated fine-needle creates cavitation in bovine liver by Perra, Emanuele, Hayward, Nick, Pritzker, Kenneth P. H., Nieminen, Heikki J.

“…Ultrasonic cavitation is being used in medical applications as a way to influence matter, such as tissue or drug vehicles, on a micro-scale. Oscillating or…”
Get full text

Predictive and prognostic cancer biomarkers revisited by Pritzker, Kenneth P H

“…While both prognostic and predictive cancer biomarkers predict clinical outcome, the term 'predictive biomarker' is reserved for the association of a specific…”
Get more information

Tumor RNA disruption predicts survival benefit from breast cancer chemotherapy by Parissenti, Amadeo M., Guo, Baoqing, Pritzker, Laura B., Pritzker, Kenneth P. H., Wang, Xiaohui, Zhu, Mu, Shepherd, Lois E., Trudeau, Maureen E.

“…In a prior substudy of the CAN-NCIC-MA.22 clinical trial (ClinicalTrials.gov identifier NCT00066443), we observed that neoadjuvant chemotherapy reduced tumor…”
Get full text

Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade? by Pritzker, Kenneth P H, Darling, Mark R, Hwang, Jason T-K, Mock, David

“…Oral epithelial dysplasia is considered a potential histologic precursor of subsequent squamous cell cancer. As standard clinical practice, pathologists grade…”
Get more information

Ultrasound-Enhanced Fine-Needle Biopsy Improves Yield in Human Epithelial and Lymphoid Tissue by Le Bourlout, Yohann, Rehell, Minna, Kelppe, Jetta, Rautava, Jaana, Perra, Emanuele, Rantanen, Jouni, Ehnholm, Gösta, Hayward, Nick, Nyman, Kristofer, Pritzker, Kenneth P.H., Tarkkanen, Jussi, Atula, Timo, Aro, Katri, Nieminen, Heikki J.

“…Needle biopsy is a common technique used to obtain cell and tissue samples for diagnostics. Currently, two biopsy methods are widely used: (i) fine-needle…”
Get full text

Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis by Tsui, Florence W L, Tsui, Hing Wo, Las Heras, Facundo, Pritzker, Kenneth P H, Inman, Robert D

“…Unravelling the basis of joint inflammation and ankylosis represents a major challenge in ankylosing spondylitis (AS) research. As noggin (NOG) and sclerostin…”
Get more information

Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) by Lin, Aifeng, Inman, Robert D, Streutker, Catherine J, Zhang, Zhenbo, Pritzker, Kenneth P H, Tsui, Hing Wo, Tsui, Florence W L

“…Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of…”
Get full text

Association between subchondral bone structure and osteoarthritis histopathological grade by Finnilä, Mikko A. J., Thevenot, Jérôme, Aho, Olli‐Matti, Tiitu, Virpi, Rautiainen, Jari, Kauppinen, Sami, Nieminen, Miika T., Pritzker, Kenneth, Valkealahti, Maarit, Lehenkari, Petri, Saarakkala, Simo

“…ABSTRACT Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone…”
Get full text

Assessing Oral Epithelial Dysplasia Risk for Transformation to Cancer: Comparison Between Histologic Grading Systems Versus S100A7 Immunohistochemical Signature-based Grading by Darling, Mark Roger, Hwang, Jason T.K., Dickson, Benjamin J., Cutz, Jean-Claude, Salama, Samih, McCord, Christina, Pritzker, Kenneth P.H., Mock, David, Thompson, Lester D.R.

“…While a 3-tier oral epithelial dysplasia grading system has been utilized for decades, it is widely recognized as a suboptimal risk indicator for…”
Get full text

Quantifying Complex Micro‐Topography of Degenerated Articular Cartilage Surface by Contrast‐Enhanced Micro‐Computed Tomography and Parametric Analyses by Ylitalo, Tuomo, Finnilä, Mikko A.J., Gahunia, Harpal K., Karhula, Sakari S., Suhonen, Heikki, Valkealahti, Maarit, Lehenkari, Petri, Hæggström, Edward, Pritzker, Kenneth P.H., Saarakkala, Simo, Nieminen, Heikki J.

“…ABSTRACT One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become…”
Get full text

Colon Cancer Biomarkers: Implications for Personalized Medicine by Pritzker, Kenneth P.H.

“…The heterogeneity of colon cancers and their reactions presents both a challenge and promise for personalized medicine. The challenge is to develop effective…”
Get full text

Individualized five-year risk assessment for oral premalignant lesion progression to cancer by Hwang, Jason T.K., PhD, Gu, Ying R., PhD, MBA, Shen, Mi, MSc, Ralhan, Ranju, PhD, Walfish, Paul G., MD, CM, O.Ont, FRCPC, FCAHS, Pritzker, Kenneth P.H., MD, FRCPC, Mock, David, DDS, PhD, FRCD(C)

“…Objective The standard of care for premalignant lesion risk assessment is dysplasia grading by histopathology. With significant overlap between dysplasia…”
Get full text

Effects of the Steroidal Aromatase Inhibitor Exemestane and the Nonsteroidal Aromatase Inhibitor Letrozole on Bone and Lipid Metabolism in Ovariectomized Rats by Goss, Paul E, Qi, Shangle, Cheung, Angela M, Hu, Haiqing, Mendes, Maria, Pritzker, Kenneth P H

“…Purpose: Exemestane (EXE) and letrozole (LET) are third-generation aromatase inhibitors currently prescribed for postmenopausal hormone-dependent breast…”
Get full text

Localized delivery of compounds into articular cartilage by using high-intensity focused ultrasound by Nieminen, Heikki J., Lampsijärvi, Eetu, Barreto, Gonçalo, Finnilä, Mikko A. J., Salmi, Ari, Airaksinen, Anu J., Eklund, Kari K., Saarakkala, Simo, Pritzker, Kenneth P. H., Hæggström, Edward

“…Localized delivery of drugs into an osteoarthritic cartilaginous lesion does not yet exist, which limits pharmaceutical management of osteoarthritis (OA)…”
Get full text

RNA disruption indicates CHOP therapy efficacy in canine lymphoma by Parissenti, Amadeo M, Pritzker, Laura B, Guo, Baoqing, Narendrula, Rashmi, Wang, Shirly Xiaohui, Lin, Lin Laura, Pei, Jingchun, Skowronski, Karolina, Bienzle, Dorothee, Woods, J Paul, Pritzker, Kenneth P H, Coomber, Brenda L

“…Assessment of the efficacy of a multi-agent chemotherapy protocol in which cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) are administered in…”
Get full text