Search Results - "PRINSEN, M. K"

Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats by Til, H.P., Falke, H.E., Prinsen, M.K., Willems, M.I.

“…The acute and subacute toxicity of five biogenic amines—tyramine, spermidine, spermine, putrescine and cadaverine-were examined in Wistar rats. Tyramine and…”
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The Draize Eye Test and in vitro alternatives; a left-handed marriage? by Prinsen, M.K.

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The chicken enucleated eye test (CEET): a practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials by Prinsen, M.K.

“…The enucleated eye test with chicken eyes (CEET) obtained from an abattoir proved to be a valuable and practical alternative for the ‘traditional’ enucleated…”
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Human volunteer study with PGME: eye irritation during vapour exposure by Emmen, H.H, Muijser, H, Arts, J.H.E, Prinsen, M.K

“…The objective of this study was to establish the possible occurrence of eye irritation and subjective symptoms in human volunteers exposed to propylene glycol…”
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Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits by Prinsen, M K, Koëter, H B

“…The enucleated eye test (EET) with the isolated eye of rabbits has been recognized as a valuable alternative to the Draize test, because it represents a test…”
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Eye irritation testing : The way forward : The report and recommendations of ECVAM Workshop 34 by BALLS, M, BERG, N, PRINSEN, M. K, SPIELMANN, H, WORTH, A. P, BRUNER, L. H, CURREN, R. D, DE SILVA, O, EARL, L. K, ESDAILE, D. J, FENTEM, J. H, LIEBSCH, M, OHNO, Y

“…This is the report of the thirty-fourth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's…”
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The isolated chicken eye test as a suitable in vitro method for determining the eye irritation potential of household cleaning products by Schutte, K., Prinsen, M.K., McNamee, P.M., Roggeband, R.

“…Eye irritation is an important endpoint in the safety evaluation of consumer products and their ingredients. Several in vitro methods have been developed and…”
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Skin sensitization testing: the relevance of rechallenge and pretreatment with sodium lauryl sulfate in the guinea pig maximization test by Prinsen, M.K., Romijn, T., Snoeij, N.J.

“…The guinea pig maximization test is one of the preferred test methods for the identification of skin sensitizers. The OECD/EC test guidelines allow for the…”
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Induction of dorsolateral prostate adenocarcinomas and other accessory sex gland lesions in male wistar rats by a single administration of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl after sequential treatment with cyproterone acetate and testosterone propionate by BOSLAND, M. C, PRINSEN, M. K

“…Groups of 20-25 male Wistar rats (Cpb:WU), nine groups of 4-week-old rats, and nine groups of 8-week-old rats, were given cyproterone acetate (CA) s.c. or by…”
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Validation—Lessons learned from practical experience by Fentem, J.H., Prinsen, M.K., Spielmann, H., Walum, E., Botham, P.A.

“…With regard to the problems encountered and the experience gained in validation studies conducted in the past, suggestions have been made concerning criteria…”
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Characterization of adenocarcinomas of the dorsolateral prostate induced in wistar rats by N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate by BOSLAND, M. C, PRINSEN, M. K, DIRKSEN, T. J. M, SPIT, B. J

“…Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl,…”
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Organotypic models for the assessment/prediction of ocular irritation by Chamberlain, M, Gad, S.C, Gautheron, P, Prinsen, M.K

“…The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group on the use of isolated eyes and…”
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Comparison of dose–responses of contact allergens using the guinea pig maximization test and the local lymph node assay by van Och, François M.M., Vandebriel, Rob J., Prinsen, Menk K., De Jong, Wim H., Slob, Wout, van Loveren, Henk

“…The guinea pig maximization test (GPMT) has been used as a method for the prediction of skin sensitizing potential for over 30 years. Besides hazard…”
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Determination of the oestrogenic (uterotrophic) activity of extracts of 'general purpose polystyrene (GPPS)' using immature female rats by Prinsen, Menk K., Gouko, Nobuaki

“…In Japan there is growing concern about the possible adverse effects of consumption of food from styrene containers (mainly those made from polystyrene paper)…”
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Irag Working Group 1: Organotypic models for the assessment/prediction of ocular irritation by Chamberlain, M., Gad, S.C., Gautheron, P., Prinsen, M.K.

“…The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group on the use of isolated eyes and…”
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Induction of skin and thyroid tumors in male rats by N-methyl-N-nitrosourea after sequential treatment with cyproterone acetate and testosterone propionate: effects of castration, rat strain and time of carcinogen injection by Bosland, M C, Prinsen, M K, Rivenson, A, Weisburger, J H

“…The purpose of this study was to determine the carcinogenic effect in male rats of a single i.v. injection of N-methyl-N-nitrosourea (MNU) after sequential…”
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Adenocarcinomas of the prostate induced by N-nitroso-N-methylurea in rats pretreated with cyproterone acetate and testosterone by Bosland, M C, Prinsen, M K, Kroes, R

“…Prostatic adenocarcinomas were induced in 5 out of 20 Wistar rats upon a single administration of 50 mg/kg N-nitroso-N-methylurea (NMU). The rats were…”
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Induction of proliferative lesions of ventral prostate, seminal vesicle, and other accessory sex glands in rats by N-methyl-N-nitrosourea: effect of castration, pretreatment with cyproterone acetate and testosterone propionate and rat strain by Bosland, M C, Prinsen, M K, Rivenson, A, Silverman, J, Fiala, E, Williams, G M, Kroes, R, Weisburger, J H

“…Wistar (Cpb:WU), F344 or Sprague-Dawley rats were sequentially treated with cyproterone acetate (CA) for 21 days, testosterone propionate (TP) for 3 days,…”
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IRAG working group 1. Organotypic models for the assessment/prediction of ocular irritation. Interagency Regulatory Alternatives Group by Chamberlain, M, Gad, S C, Gautheron, P, Prinsen, M K

“…The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group on the use of isolated eyes and…”
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Human volunteer study with PGME: eye irritation during vapour exposure by EMMEN, H. H, MUIJSER, H, ARTS, J. H. E, PRINSEN, M. K

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