Search Results - "PRINS, N. D"

Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI by DEN HEIJER, T, VERMEER, S. E, VAN DIJK, E. J, PRINS, N. D, KOUDSTAAL, P. J, HOFMAN, A, BRETELER, M. M. B

“…Type 2 diabetes increases the risk not only of vascular dementia but also of Alzheimer's disease. The question remains whether diabetes increases the risk of…”
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Trajectories of cognitive decline in different types of dementia by Smits, L L, van Harten, A C, Pijnenburg, Y A L, Koedam, E L G E, Bouwman, F H, Sistermans, N, Reuling, I E W, Prins, N D, Lemstra, A W, Scheltens, P, van der Flier, W M

“…To investigate trajectories of cognitive decline in patients with different types of dementia compared to controls in a longitudinal study. In 199 patients…”
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C-reactive protein and cerebral small-vessel disease : The Rotterdam scan study by VAN DIJK, E. J, PRINS, N. D, VERMEER, S. E, VROOMAN, H. A, HOFMAN, A, KOUDSTAAL, P. J, BRETELER, M. M. B

“…Inflammatory processes are involved in the development and consequences of atherosclerosis. Whether these processes are also involved in cerebral small-vessel…”
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Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe by DEN HEIJER, T, LAUNER, L. J, PRINS, N. D, VAN DIJK, E. J, VERMEER, S. E, HOFMAN, A, KOUDSTAAL, P. J, BRETELER, M. M. B

“…Blood pressure level is associated with the risk of clinical Alzheimer disease (AD), yet the underlying mechanisms are unclear. High blood pressure levels may…”
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Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD—VIVIAD by Vijverberg, E. G. B., Axelsen, T. M., Bihlet, A. R., Henriksen, K., Weber, F., Fuchs, K., Harrison, J. E., Kühn-Wache, K., Alexandersen, P., Prins, N. D., Scheltens, Philip

“…Background Varoglutamstat (formerly PQ912) is a small molecule that inhibits the activity of the glutaminyl cyclase to reduce the level of pyroglutamate-A-beta…”
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Homocysteine and cognitive function in the elderly: The Rotterdam Scan Study by PRINS, N. D, DEN HEIJER, T, HOFMAN, A, KOUDSTAAL, P. J, JOLLES, J, CLARKE, R, BRETELER, M. M. B

“…Elevated plasma total homocysteine (tHcy) concentrations are associated with AD and vascular dementia, but the relation with cognitive performance in…”
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High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study by van Loenhoud, A C, de Boer, C, Wols, K, Pijnenburg, Y A, Lemstra, A W, Bouwman, F H, Prins, N D, Scheltens, P, Ossenkoppele, R, van der Flier, W M

“…Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although…”
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Measuring progression of cerebral white matter lesions on MRI: Visual rating and volumetrics by PRINS, N. D, VAN STRAATEN, E. C. W, VAN DIJK, E. J, SIMONI, M, VAN SCHIJNDEL, R. A, VROOMAN, H. A, KOUDSTAAL, P. J, SCHELTENS, P, BRETELER, M. M. B, BARKHOF, F

“…To evaluate the concordance of a volumetric method for measuring white matter lesion (WML) change with visual rating scales. The authors selected a stratified…”
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Efficacy of early cognitive–linguistic treatment and communicative treatment in aphasia after stroke: a randomised controlled trial (RATS-2) by de Jong-Hagelstein, M, van de Sandt-Koenderman, W M E, Prins, N D, Dippel, D W J, Koudstaal, P J, Visch-Brink, E G

“…BackgroundThe two main approaches in aphasia treatment are cognitive–linguistic treatment (CLT), aimed at restoring the linguistic levels affected, semantics,…”
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MR spectroscopy of brain white matter in the prediction of dementia by DEN HEIJER, T, SIJENS, P. E, PRINS, N. D, HOFMAN, A, KOUDSTAAL, P. J, OUDKERK, M, BRETELER, M. M. B

“…Previous 1H-MR spectroscopy (MRS) studies compared biochemical spectra of persons with dementia with those of healthy control subjects. Given the long…”
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Arterial oxygen saturation, COPD, and cerebral small vessel disease by van Dijk, E J, Vermeer, S E, de Groot, J C, van de Minkelis, J, Prins, N D, Oudkerk, M, Hofman, A, Koudstaal, P J, Breteler, M M B

“…Objective: To study whether lower arterial oxygen saturation (SaO2) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter…”
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Neuroanatomical localisation and clinical correlates of white matter lesions in the elderly by Artero, S, Tiemeier, H, Prins, N D, Sabatier, R, Breteler, M M B, Ritchie, K

“…Background: White matter lesions (WML) in elderly people co-occur with hypertension, depression, and cognitive impairment. Little is known about the density…”
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Performance of five automated white matter hyperintensity segmentation methods in a multicenter dataset by Heinen, Rutger, Steenwijk, Martijn D., Barkhof, Frederik, Biesbroek, J. Matthijs, van der Flier, Wiesje M., Kuijf, Hugo J., Prins, Niels D., Vrenken, Hugo, Biessels, Geert Jan, de Bresser, Jeroen

“…White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease, that is increasingly studied with large, pooled multicenter…”
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Grey zone amyloid burden affects memory function: the SCIENCe project by Ebenau, J. L., Verfaillie, S. C. J., van den Bosch, K. A., Timmers, T., Wesselman, L. M. P., van Leeuwenstijn, M., Tuncel, H., Golla, S. V. S., Yaqub, M. M., Windhorst, A. D., Prins, N. D., Barkhof, F., Scheltens, P., van der Flier, W. M., van Berckel, B. N. M.

“…Purpose To determine thresholds for amyloid beta pathology and evaluate associations with longitudinal memory performance with the aim to identify a grey zone…”
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Phase 2A Learnings Incorporated into RewinD-LB, a Phase 2B Clinical Trial of Neflamapimod in Dementia with Lewy Bodies by Prins, N. D., de Haan, W., Gardner, A., Blackburn, K., Chu, H.-M., Galvin, J. E., Alam, John J.

“…Background In an exploratory 91-participant phase 2a clinical trial (AscenD-LB, NCT04001517) in dementia with Lewy bodies (DLB), neflamapimod showed…”
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Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline by Vermeer, Sarah E, Prins, Niels D, den Heijer, Tom, Hofman, Albert, Koudstaal, Peter J, Breteler, Monique M.B

“…Silent brain infarcts (i.e., infarcts without associated neurologic symptoms) are common, and their clinical significance is unclear. In this population-based…”
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Disturbed phase relations in white matter hyperintensity based vascular dementia: An EEG directed connectivity study by van Straaten, E.C.W, den Haan, J, de Waal, H, van der Flier, W.M, Barkhof, F, Prins, N.D, Stam, C.J

“…Highlights • Directed functional connectivity shows a phase lead of the frontal regions to parieto-occipital regions in subjects without objective cognitive…”
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Frequency of white matter lesions and silent lacunar infarcts by van Dijk, E J, Prins, N D, Vermeer, S E, Koudstaal, P J, Breteler, M M B

“…White matter lesions and silent lacunar infarcts are related to and may result from cerebral small vessel disease. Reported frequencies of these lesions vary…”
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Targeting Lifestyle Behavior to Improve Brain Health: User-Experiences of an Online Program for Individuals with Subjective Cognitive Decline by Wesselman, Linda M. P., Schild, A. K., Hooghiemstra, A. M., Meiberth, D., Drijver, A. J., Leeuwenstijn-Koopman, M. V., Prins, N. D., Brennan, S., Scheltens, P., Jessen, F., van der Flier, W. M., Sikkes, S. A. M.

“…Background Online programs targeting lifestyle have the potential to benefit brain health. We aimed to develop such a program for individuals with subjective…”
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Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings by Vermunt, Lisa, Muniz-Terrera, Graciela, Ter Meulen, Lea, Veal, Colin, Blennow, Kaj, Campbell, Archie, Carrié, Isabelle, Delrieu, Julien, Fauria, Karine, Huesa Rodríguez, Gema, Ingala, Silvia, Jenkins, Natalie, Molinuevo, José Luis, Ousset, Pierre-Jean, Porteous, David, Prins, Niels D, Solomon, Alina, Tom, Brian D, Zetterberg, Henrik, Zwan, Marissa, Ritchie, Craig W, Scheltens, Philip, Luscan, Gerald, Brookes, Anthony J, Visser, Pieter Jelle

“…Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically…”
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