Search Results - "PRIMIANO, T"

Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase : implications for chemoprevention by PRIMIANO, T, LI, Y, KENSLER, T. W, TRUSH, M. A, SUTTER, T. R

“…Cancer chemoprevention is inhibition of neoplastic disease by naturally occurring or synthetic chemical agents. Dithiolethiones inhibit production of…”
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Glutathione S-transferases and gamma-glutamyl transpeptidase in the rat nervous systems: a basis for differential susceptibility to neurotoxicants by Philbert, M A, Beiswanger, C M, Manson, M M, Green, J A, Novak, R F, Primiano, T, Reuhl, K R, Lowndes, H E

“…Glutathione and its related enzymes play a major role in the detoxification of toxic chemicals. In rat brain the pattern of distribution of reduced glutathione…”
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Differential expression of glutathione S-transferase isoforms in compartments of the testis and segments of the epididymis of the rat by Gandy, J, Primiano, T, Novak, R F, Kelce, W R, York, J L

“…Specific cell types of the mammalian testes demonstrate varying susceptibility to toxic insult by chemical agents. The mammalian testis is divided into two…”
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Purification and characterization of class mu glutathione S-transferase isozymes from rabbit hepatic tissue by Primiano, T, Novak, R F

“…Class mu glutathione S-transferases (GSTs) are important in the detoxication of epoxides generated by oxidative metabolism. Phenobarbital,…”
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Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis by Kong, A N, Yu, R, Chen, C, Mandlekar, S, Primiano, T

“…Many natural products elicit diverse pharmacological effects. Using two classes of potential chemopreventive compounds, the phenolic compounds and the…”
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Enhanced glutathione S-transferase 7-7 expression in rat hepatic cytosol following treatment with pyrrole by Primiano, T, Gandy, J, York, J L, Novak, R F

“…Rat hepatic GST 7-7 expression in cytosol and in the S-hexylglutathione-agarose affinity purified fraction of cytosol from saline- (control) and…”
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements by Primiano, Thomas, Baig, Mirza, Maliyekkel, Anil, Chang, Bey-Dih, Fellars, Stacey, Sadhu, Justin, Axenovich, Sergey A, Holzmayer, Tatyana A, Roninson, Igor B

“…To identify human genes required for tumor cell growth, transcriptome-scale selection was used to isolate genetic suppressor elements (GSEs) inhibiting breast…”
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Antioxidant-inducible genes by Primiano, T, Sutter, T R, Kensler, T W

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cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3 by Knight, Laundette P., Primiano, Thomas, Groopman, John D., Kensler, Thomas W., Sutter, Thomas R.

“…The aflatoxin B1 (AFB1) aldehyde metabolite of AFB1 may contribute to the cytotoxicity of this hepatocarcinogen via protein adduction. Aflatoxin B1 aldehyde…”
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Intermittent dosing with oltipraz : relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases by PRIMIANO, T, EGNER, P. A, SUTTER, T. R, KELLOFF, G. J, ROEBUCK, B. D, KENSLER, T. W

“…Oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against chemical carcinogenesis in several animal models and is currently under evaluation…”
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Isolation of cDNAs representing dithiolethione-responsive genes by Primiano, Thomas, Gastel, Jonathan A., Kensler, Thomas W., Sutter, Thomas R.

“…Dithiolethiones inhibit tumorigenicity elicited by many structurally diverse carcinogens in numerous target tissues. These protective actions are associated…”
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Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones by Primiano, Thomas, Kensler, Thomas W., Kuppusamy, Periannan, Zweier, Jay L., Sutter, Thomas R.

“…Treatment of rats with the cancer chemopreventive agent 1, 2-dithiole-3-thione (D3T) resulted in a significant increase in hepatic heme oxygenase (HO)…”
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements by Primiano, Thomas, Baig, Mirza, Maliyekkel, Anil, Chang, Bey-Dih, Fellars, Stacey, Sadhu, Justin, Axenovich, Sergey A, Holzmayer, Tatyana A, Roninson, Igor B

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Redox Regulation of Genes that Protect Against Carcinogens by Primiano, Thomas, Sutter, Thomas R, Kensler, Thomas W

“…Most carcinogens require activation to electrophilic metabolites or species that generate reactive oxygen in order to initiate the tumorigenic process. These…”
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Identification of dithiolethione-inducible gene-1 as a leukotriene B sub(4) 12-hydroxydehydrogenase: implications for chemoprevention by Primiano, T, Li, Yunbo, Kensler, T W, Trush, MA, Sutter, T R

“…Cancer chemoprevention is inhibition of neoplastic disease by naturally occurring or synthetic chemical agents. Dithiolethiones inhibit production of…”
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Induction of leukotriene B4 metabolism by cancer chemopreventive agents by Primiano, T, Kensler, T W, Trush, M A, Sutter, T R

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Isolation of cDNAs repesenting dithiolethione-responsive genes by PRIMIANO, T, GASTEL, J. A, KENSLER, T. W, SUTTER, T. R

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Enhanced expression, purification, and characterization of a novel class alpha glutathione S-transferase isozyme appearing in rabbit hepatic cytosol following treatment with 4-picoline by Primiano, T, Novak, R F

“…A novel class alpha glutathione S-transferase (GST) isozyme is expressed in the hepatic cytosol of rabbits treated with 4-picoline. SDS-PAGE analysis revealed…”
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Differences between rats and rabbits in hepatic cytosolic glutathione S-transferase expression in response to nitrogen heterocycle and other inducers by Primiano, T, Kim, S G, Novak, R F

“…Glutathione S-transferase (GST) expression was examined in hepatic cytosol from rats and rabbits treated with 4-picoline, pyrrole, pyridine, pyrazine,…”
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Changes in adult metabolism of aflatoxin B1 in rats neonatally exposed to diethylstilbestrol. Alterations in alpha-class glutathione S-transferases by Zangar, R C, Springer, D L, McCrary, J A, Novak, R F, Primiano, T, Buhler, D R

“…Neonatal exposure of rats to xenobiotics has been shown to produce long-term alterations in hepatic enzyme activities and in levels of DNA adducts following…”
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