Search Results - "PRICE, David A"

Five-Year Graft Survival of Descemet Membrane Endothelial Keratoplasty (EK) versus Descemet Stripping EK and the Effect of Donor Sex Matching by Price, David A., Kelley, Meagan, Price, Francis W., Price, Marianne O.

“…To determine whether the reduced risk of immunologic rejection with Descemet membrane endothelial keratoplasty (DMEK) results in a 5-year survival advantage…”
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Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States by Stepan, Antonia F, Walker, Daniel P, Bauman, Jonathan, Price, David A, Baillie, Thomas A, Kalgutkar, Amit S, Aleo, Michael D

“…Because of a preconceived notion that eliminating reactive metabolite (RM) formation with new drug candidates could mitigate the risk of idiosyncratic drug…”
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Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance by Davey, Martin S., Willcox, Carrie R., Joyce, Stephen P., Ladell, Kristin, Kasatskaya, Sofya A., McLaren, James E., Hunter, Stuart, Salim, Mahboob, Mohammed, Fiyaz, Price, David A., Chudakov, Dmitriy M., Willcox, Benjamin E.

“…γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use…”
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Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia by Anguille, Sébastien, Van de Velde, Ann L., Smits, Evelien L., Van Tendeloo, Viggo F., Juliusson, Gunnar, Cools, Nathalie, Nijs, Griet, Stein, Barbara, Lion, Eva, Van Driessche, Ann, Vandenbosch, Irma, Verlinden, Anke, Gadisseur, Alain P., Schroyens, Wilfried A., Muylle, Ludo, Vermeulen, Katrien, Maes, Marie-Berthe, Deiteren, Kathleen, Malfait, Ronald, Gostick, Emma, Lammens, Martin, Couttenye, Marie M., Jorens, Philippe, Goossens, Herman, Price, David A., Ladell, Kristin, Oka, Yoshihiro, Fujiki, Fumihiro, Oji, Yusuke, Sugiyama, Haruo, Berneman, Zwi N.

“…Relapse is a major problem in acute myeloid leukemia (AML) and adversely affects survival. In this phase 2 study, we investigated the effect of vaccination…”
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NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs by Béziat, Vivien, Liu, Lisa L., Malmberg, Jenny-Ann, Ivarsson, Martin A., Sohlberg, Ebba, Björklund, Andreas T., Retière, Christelle, Sverremark-Ekström, Eva, Traherne, James, Ljungman, Per, Schaffer, Marie, Price, David A., Trowsdale, John, Michaëlsson, Jakob, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan

“…Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I…”
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Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease by Mayassi, Toufic, Ladell, Kristin, Gudjonson, Herman, McLaren, James E., Shaw, Dustin G., Tran, Mai T., Rokicka, Jagoda J., Lawrence, Ian, Grenier, Jean-Christophe, van Unen, Vincent, Ciszewski, Cezary, Dimaano, Matthew, Sayegh, Hoda E., Kumar, Vinod, Wijmenga, Cisca, Green, Peter H.R., Gokhale, Ranjana, Jericho, Hilary, Semrad, Carol E., Guandalini, Stefano, Dinner, Aaron R., Kupfer, Sonia S., Reid, Hugh H., Barreiro, Luis B., Rossjohn, Jamie, Price, David A., Jabri, Bana

“…Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic…”
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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules by Pye, Cameron R, Hewitt, William M, Schwochert, Joshua, Haddad, Terra D, Townsend, Chad E, Etienne, Lyns, Lao, Yongtong, Limberakis, Chris, Furukawa, Akihiro, Mathiowetz, Alan M, Price, David A, Liras, Spiros, Lokey, R. Scott

“…Macrocyclic peptides are considered large enough to inhibit “undruggable” targets, but the design of passively cell-permeable molecules in this space remains a…”
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Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity by Edwards, Emily S.J., Bier, Julia, Cole, Theresa S., Wong, Melanie, Hsu, Peter, Berglund, Lucinda J., Boztug, Kaan, Lau, Anthony, Gostick, Emma, Price, David A., O'Sullivan, Michael, Meyts, Isabelle, Choo, Sharon, Gray, Paul, Holland, Steven M., Deenick, Elissa K., Uzel, Gulbu, Tangye, Stuart G.

“…Germline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110δ subunit of phosphoinositide 3-kinase (PI3K), result in hyperactivation of the…”
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CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells by Brenna, Elena, Davydov, Alexey N., Ladell, Kristin, McLaren, James E., Bonaiuti, Paolo, Metsger, Maria, Ramsden, James D., Gilbert, Sarah C., Lambe, Teresa, Price, David A., Campion, Suzanne L., Chudakov, Dmitriy M., Borrow, Persephone, McMichael, Andrew J.

“…T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a…”
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A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells by Ladell, Kristin, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James E., Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie, Price, David A., Appay, Victor

“…The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we…”
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Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients by Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David A., Fairlie, David P., Craik, David J.

“…Significance Peptides are valuable leads for drug development, offering advantages over other molecular classes. Specifically, they can bind potently and…”
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Fmoc-Based Synthesis of Disulfide-Rich Cyclic Peptides by Cheneval, Olivier, Schroeder, Christina I, Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A, Craik, David J

“…Disulfide-rich cyclic peptides have exciting potential as leads or frameworks in drug discovery; however, their use is faced with some synthetic challenges,…”
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MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape by Pymm, Phillip, Illing, Patricia T, Ramarathinam, Sri H, O'Connor, Geraldine M, Hughes, Victoria A, Hitchen, Corinne, Price, David A, Ho, Bosco K, McVicar, Daniel W, Brooks, Andrew G, Purcell, Anthony W, Rossjohn, Jamie, Vivian, Julian P

“…Structural determination and analysis of HLA-I that presents an HIV-derived peptide to an NK cell receptor reveal that N-terminal extended epitope…”
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Molecular basis for universal HLA-A0201–restricted CD8⁺ T-cell immunity against influenza viruses by Valkenburg, Sophie A., Josephs, Tracy M., Clemens, E. Bridie, Grant, Emma J., Nguyen, Thi H. O., Wang, George C., Price, David A., Miller, Adrian, Tong, Steven Y. C., Thomas, Paul G., Doherty, Peter C., Rossjohn, Jamie, Gras, Stephanie, Kedzierska, Katherine

“…Memory CD8⁺ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral proteins confer broad protection against distinct strains of…”
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On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds by White, Tina R, Renzelman, Chad M, Rand, Arthur C, Rezai, Taha, McEwen, Cayla M, Gelev, Vladimir M, Turner, Rushia A, Linington, Roger G, Leung, Siegfried S F, Kalgutkar, Amit S, Bauman, Jonathan N, Zhang, Yizhong, Liras, Spiros, Price, David A, Mathiowetz, Alan M, Jacobson, Matthew P, Lokey, R Scott

“…A single trimethylated species is obtained in an on-resin N-methylation reaction of a cyclic hexapeptide. This regioselectivity is driven by conformation and…”
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Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable by Nielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Hill, Timothy A., Lucke, Andrew J., Craik, David J., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Fairlie, David P.

“…The use of peptides in medicine is limited by low membrane permeability, metabolic instability, high clearance, and negligible oral bioavailability. The…”
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection by Douek, Daniel C, Brenchley, Jason M, Price, David A, Schacker, Timothy W, Asher, Tedi E, Silvestri, Guido, Rao, Srinivas, Kazzaz, Zachary, Bornstein, Ethan, Lambotte, Olivier, Altmann, Daniel, Blazar, Bruce R, Rodriguez, Benigno, Teixeira-Johnson, Leia, Landay, Alan, Martin, Jeffrey N, Hecht, Frederick M, Picker, Louis J, Lederman, Michael M, Deeks, Steven G

“…Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology…”
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Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab by Ming, Qianqian, Antfolk, Daniel, Price, David A., Manturova, Anna, Medina, Elliot, Singh, Srishti, Mason, Charlotte, Tran, Timothy H., Smalley, Keiran S. M., Leung, Daisy W., Luca, Vincent C.

“…The immune checkpoint protein, Lymphocyte activation gene-3 (LAG3), binds Major Histocompatibility Complex Class II (MHC-II) and suppresses T cell activation…”
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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function by Thomas, Sharyn, Mohammed, Fiyaz, Reijmers, Rogier M., Woolston, Annemarie, Stauss, Theresa, Kennedy, Alan, Stirling, David, Holler, Angelika, Green, Louisa, Jones, David, Matthews, Katherine K., Price, David A., Chain, Benjamin M., Heemskerk, Mirjam H. M., Morris, Emma C., Willcox, Benjamin E., Stauss, Hans J.

“…TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell…”
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Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition by Saunders, Philippa M, Pymm, Phillip, Pietra, Gabriella, Hughes, Victoria A, Hitchen, Corinne, O'Connor, Geraldine M, Loiacono, Fabrizio, Widjaja, Jacqueline, Price, David A, Falco, Michela, Mingari, Maria Cristina, Moretta, Lorenzo, McVicar, Daniel W, Rossjohn, Jamie, Brooks, Andrew G, Vivian, Julian P

“…Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism…”
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