Search Results - "PRAVENEC, Michal"

Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure by Morris, R Curtis, Pravenec, Michal, Šilhavý, Jan, DiCarlo, Stephen E, Kurtz, Theodore W

“…To reduce the risk of salt-induced hypertension, medical authorities have emphasized dietary guidelines promoting high intakes of potassium and low intakes of…”
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CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study by Silhavy, Jan, Mlejnek, Petr, Šimáková, Miroslava, Marková, Irena, Malínská, Hana, Hüttl, Martina, Kazdová, Ludmila, Kazantsev, Dmitry, Mancini, Massimiliano, Novotný, Jiří, Pravenec, Michal

“…Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of…”
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The pivotal role of renal vasodysfunction in salt sensitivity and the initiation of salt-induced hypertension by Kurtz, Theodore W, DiCarlo, Stephen E, Pravenec, Michal, Morris, R Curtis

“…PURPOSE OF REVIEWFor decades, it has been widely accepted that initiation of salt-induced hypertension involves a type of kidney dysfunction (natriuretic…”
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Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats by Nemeckova, Ivana, Eissazadeh, Samira, Rathouska, Jana Urbankova, Silhavy, Jan, Malinska, Hana, Pravenec, Michal, Nachtigal, Petr

“…C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked…”
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WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling by Chen, Huimei, Moreno-Moral, Aida, Pesce, Francesco, Devapragash, Nithya, Mancini, Massimiliano, Heng, Ee Ling, Rotival, Maxime, Srivastava, Prashant K., Harmston, Nathan, Shkura, Kirill, Rackham, Owen J. L., Yu, Wei-Ping, Sun, Xi-Ming, Tee, Nicole Gui Zhen, Tan, Elisabeth Li Sa, Barton, Paul J. R., Felkin, Leanne E., Lara-Pezzi, Enrique, Angelini, Gianni, Beltrami, Cristina, Pravenec, Michal, Schafer, Sebastian, Bottolo, Leonardo, Hubner, Norbert, Emanueli, Costanza, Cook, Stuart A., Petretto, Enrico

“…Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems…”
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Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model by Hüttl, Martina, Markova, Irena, Miklánková, Denisa, Zapletalova, Iveta, Kujal, Petr, Šilhavý, Jan, Pravenec, Michal, Malinska, Hana

“…Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we…”
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An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure by Kurtz, Theodore W, DiCarlo, Stephen E, Pravenec, Michal, Morris, Jr, R Curtis

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Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity by Kurtz, Theodore W, DiCarlo, Stephen E, Pravenec, Michal, Morris, R Curtis

“…High-salt intake is one of the major dietary determinants of increased blood pressure and cardiovascular disease. Thus, there is scientific and medical…”
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A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion by Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan

“…Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the…”
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Distribution and functional impact of DNA copy number variation in the rat by Hubner, Norbert, Aitman, Timothy, Cook, Stuart, Jacob, Howard, Cuppen, Edwin, Pravenec, Michal, Saar, Kathrin, Verheul, Mark, van Heesch, Sebastiaan A A C, Adamovic, Tatjana, Shull, James D, Guryev, Victor

“…The abundance and dynamics of copy number variants (CNVs) in mammalian genomes poses new challenges in the identification of their impact on natural and…”
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Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility by Mihola, Ondrej, Landa, Vladimir, Pratto, Florencia, Brick, Kevin, Kobets, Tatyana, Kusari, Fitore, Gasic, Srdjan, Smagulova, Fatima, Grey, Corinne, Flachs, Petr, Gergelits, Vaclav, Tresnak, Karel, Silhavy, Jan, Mlejnek, Petr, Camerini-Otero, R Daniel, Pravenec, Michal, Petukhova, Galina V, Trachtulec, Zdenek

“…Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of…”
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Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose by Senko, Anna N, Overall, Rupert W, Silhavy, Jan, Mlejnek, Petr, Malínská, Hana, Hüttl, Martina, Marková, Irena, Fabel, Klaus S, Lu, Lu, Stuchlik, Ales, Williams, Robert W, Pravenec, Michal, Kempermann, Gerd

“…Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases…”
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Wars2 is a determinant of angiogenesis by Wang, Mao, Sips, Patrick, Khin, Ester, Rotival, Maxime, Sun, Ximing, Ahmed, Rizwan, Widjaja, Anissa Anindya, Schafer, Sebastian, Yusoff, Permeen, Choksi, Pervinder Kaur, Ko, Nicole Shi Jie, Singh, Manvendra K., Epstein, David, Guan, Yuguang, Houštěk, Josef, Mracek, Tomas, Nuskova, Hana, Mikell, Brittney, Tan, Jessie, Pesce, Francesco, Kolar, Frantisek, Bottolo, Leonardo, Mancini, Massimiliano, Hubner, Norbert, Pravenec, Michal, Petretto, Enrico, MacRae, Calum, Cook, Stuart A

“…Coronary flow (CF) measured ex vivo is largely determined by capillary density that reflects angiogenic vessel formation in the heart in vivo . Here we exploit…”
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Transposon‐mediated transgenesis, transgenic rescue, and tissue‐specific gene expression in rodents and rabbits by Katter, Katharina, Geurts, Aron M., Hoffmann, Orsolya, Mátés, Lajos, Landa, Vladimir, Hiripi, László, Moreno, Carol, Lazar, Jozef, Bashir, Sanum, Zidek, Vaclav, Popova, Elena, Jerchow, Boris, Becker, Katja, Devaraj, Anantharam, Walter, Ingrid, Grzybowksi, Michael, Corbett, Molly, Filho, Artur Rangel, Hodges, Matthew R., Bader, Michael, Ivics, Zoltán, Jacob, Howard J., Pravenec, Michal, Bősze, Zsuzsanna, Rülicke, Thomas, Izsvák, Zsuzsanna

“…Germline transgenesis is an important procedure for functional investigation of biological pathways, as well as for animal biotechnology. We have established a…”
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Natural variation of histone modification and its impact on gene expression in the rat genome by Rintisch, Carola, Heinig, Matthias, Bauerfeind, Anja, Schafer, Sebastian, Mieth, Christin, Patone, Giannino, Hummel, Oliver, Chen, Wei, Cook, Stuart, Cuppen, Edwin, Colomé-Tatché, Maria, Johannes, Frank, Jansen, Ritsert C, Neil, Helen, Werner, Michel, Pravenec, Michal, Vingron, Martin, Hubner, Norbert

“…Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of…”
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Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein by Malínská, Hana, Oliyarnyk, Olena, Škop, Vojtěch, Šilhavý, Jan, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Kazdová, Ludmila, Pravenec, Michal

“…Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for…”
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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease by Pravenec, Michal, Aitman, Timothy J, Hubner, Norbert, Wallace, Caroline A, Zimdahl, Heike, Petretto, Enrico, Schulz, Herbert, Maciver, Fiona, Mueller, Michael, Hummel, Oliver, Monti, Jan, Zidek, Vaclav, Musilova, Alena, Kren, Vladimir, Causton, Helen, Game, Laurence, Born, Gabriele, Schmidt, Sabine, Müller, Anita, Cook, Stuart A, Kurtz, Theodore W, Whittaker, John

“…Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this…”
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Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats by Liška, František, Peterková, Renata, Peterka, Miroslav, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Křen, Vladimír, Starker, Colby G, Voytas, Daniel F, Izsvák, Zsuzsanna, Pravenec, Michal

“…[This corrects the article DOI: 10.1371/journal.pone.0164206.]…”
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Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation by Junková, Kristýna, Mirchi, Lukáš F, Chylíková, Blanka, Janků, Michaela, Šilhavý, Jan, Hüttl, Martina, Marková, Irena, Miklánková, Denisa, Včelák, Josef, Malínská, Hana, Pravenec, Michal, Šeda, Ondřej, Liška, František

“…Metabolic syndrome (MetS) is an important cause of worldwide morbidity and mortality. Its complex pathogenesis includes, on the one hand, sedentary lifestyle…”
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Nestin expression in the myocardium of normotensive and spontaneously hypertensive rats during aging by Cizkova, Dana, Zurmanova, Jitka M., Gerykova, Lucie, Elsnicova, Barbara, Galatik, Frantisek, Silhavy, Jan, Pravenec, Michal, Mokry, Jaroslav

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