Search Results - "PRAVENEC, M"

Recent progress in the genetics of spontaneously hypertensive rats by Pravenec, M, Křen, V, Landa, V, Mlejnek, P, Musilová, A, Šilhavý, J, Šimáková, M, Zídek, V

“…The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Recent…”
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Transgenic overexpression of the Nrf2 ameliorates insulin resistance and changes fatty acids in membrane phospholipids in spontaneously hypertensive rats by Markova, I, Malinska, H, Oliyarnyk, O, Kazdova, L, Pravenec, M

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Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet by Šilhavý, J, Mlejnek, P, Šimáková, M, Vaněčková, I, Behuliak, M, Kuda, O, Sticová, E, Jirsa, M, Pravenec, M

“…Telmisartan is an angiotensin receptor blocker (ARB) and a selective peroxisome proliferator activated receptor gamma (PPARG) modulator. Recently, we tested…”
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Lipid-lowering and antioxidant effect of metformin in spontaneously hypertensive rats expressing human c-reactive protein by Oliyarnyk, O, Malinska, H, Skop, V, Kazdova, L, Pravenec, M

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Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats by Šilhavý, J, Krijt, J, Sokolová, J, Zídek, V, Mlejnek, P, Šimáková, M, Škop, V, Trnovská, J, Oliyarnyk, O, Marková, I, Hüttl, M, Malínská, H, Kazdová, L, Liška, F, Kožich, V, Pravenec, M

“…Increased levels of plasma cysteine predispose to obesity and metabolic disturbances. Our recent genetic analyses in spontaneously hypertensive rats (SHR)…”
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Comparative effect of silymarin and silybin treatment on inflammation and oxidative stress in transgenic spontaneously hypertensive rats overexpressing human C-reactive protein by Oliyarnyk, O, Malinska, H, Markova, I, Trnovska, J, Skop, V, Kazdova, L, Vecera, R, Pravenec, M

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Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity by Pravenec, M, Zídek, V, Landa, V, Mlejnek, P, Šilhavý, J, Šimáková, M, Trnovská, J, Škop, V, Marková, I, Malínská, H, Hüttl, M, Kazdová, L, Bardová, K, Tauchmannová, K, Vrbacký, M, Nůsková, H, Mráček, T, Kopecký, J, Houštěk, J

“…Brown adipose tissue (BAT) plays an important role in lipid and glucose metabolism in rodents and possibly also in humans. Identification of genes responsible…”
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Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis by Abdelmagid, Nada, Bereczky-Veress, Biborka, Atanur, Santosh, Musilová, Alena, Zídek, Václav, Saba, Laura, Warnecke, Andreas, Khademi, Mohsen, Studahl, Marie, Aurelius, Elisabeth, Hjalmarsson, Anders, Garcia-Diaz, Ana, Denis, Cécile V, Bergström, Tomas, Sköldenberg, Birgit, Kockum, Ingrid, Aitman, Timothy, Hübner, Norbert, Olsson, Tomas, Pravenec, Michal, Diez, Margarita

“…Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain…”
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Connexin 50 mutation lowers blood pressure in spontaneously hypertensive rat by Šeda, O, Liška, F, Pravenec, M, Vernerová, Z, Kazdová, L, Křenová, D, Zídek, V, Šedová, L, Krupková, M, Křen, V

“…We assessed the effect of the previously uncovered gap junction protein alpha 8 (Gja8) mutation present in spontaneously hypertensive rat - dominant cataract…”
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Genetically determined folate deficiency is associated with abnormal hepatic folate profiles in the spontaneously hypertensive rat by Pravenec, M, Leung, K Y, Zídek, V, Mlejnek, P, Šimáková, M, Šilhavý, J, Kožich, V, Greene, N D E

“…Increased levels of plasma cysteine are associated with obesity and metabolic disturbances. Our recent genetic analyses in spontaneously hypertensive rats…”
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Fumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats by Pravenec, M, Silhavy, J, Zidek, V, Mlejnek, P, Landa, V, Simakova, M, Strnad, H, Oliyarnyk, O, Kazdova, L, Kurtz, T.W

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Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats by Pravenec, M, Landa, V, Zídek, V, Mlejnek, P, Šilhavý, J, Mir, S A, Vaingankar, S M, Wang, J, Kurtz, T W

“…The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and left ventricular hypertrophy. Catecholamines play…”
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Molecule-specific Effects of Angiotensin II–Receptor Blockers Independent of the Renin–Angiotensin System by Kurtz, Theodore W., Pravenec, Michal

“…Because all clinically approved angiotensin-receptor blockers (ARBs) have good safety profiles and share the ability to block angiotensin II type 1 (AT1)…”
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Hepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein by Škop, V, Trnovská, J, Oliyarnyk, O, Marková, I, Malínská, H, Kazdová, L, Zídek, V, Landa, V, Mlejnek, P, Šimáková, M, Kůdela, M, Pravenec, M, Šilhavý, J

“…Dyslipidemia and inflammation play an important role in the pathogenesis of cardiovascular and liver disease. Fenofibrate has a well-known efficacy to reduce…”
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Tissue-Specific Peroxisome Proliferator Activated Receptor Gamma Expression and Metabolic Effects of Telmisartan by Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Šilhavý, Jan, Landa, Vladimír, Kazdová, Ludmila, Pravenec, Michal, Kurtz, Theodore W.

“…BACKGROUND The angiotensin receptor blocker telmisartan has unique chemical properties that enable it to partially activate the peroxisome proliferator…”
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Autocrine effects of visfatin on hepatocyte sensitivity to insulin action by Skop, V, Kontrová, K, Zídek, V, Pravenec, M, Kazdová, L, Mikulík, K, Sajdok, J, Zídková, J

“…Visfatin was originally described as an adipokine with insulin mimetic effects. Recently, it was found that visfatin is identical with the Nampt (nicotinamide…”
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Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein by Šilhavý, J, Zídek, V, Landa, V, Šimáková, M, Mlejnek, P, Oliyarnyk, O, Malínská, H, Kazdová, L, Mancini, M, Pravenec, M

“…Recently, we derived "humanized" spontaneously hypertensive rats (SHR-CRP) in which transgenic expression of human CRP induces inflammation, oxidative stress,…”
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Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats by Landa, V, Zídek, V, Mlejnek, P, Šimáková, M, Šilhavý, J, Trnovská, J, Kazdová, L, Pravenec, M

“…It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol…”
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Pharmacogenetic analysis of captopril effects on blood pressure: possible role of the Ednrb (endothelin receptor type B) candidate gene by Zicha, J, Dobešová, Z, Zídek, V, Silhavý, J, Simáková, M, Mlejnek, P, Vaněčková, I, Kuneš, J, Pravenec, M

“…The objective of the current study was to search for genetic determinants associated with antihypertensive effects of angiotensin-converting enzyme (ACE)…”
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Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat by Jirout, M.L., Friese, R.S., Mahapatra, N.R., Mahata, M., Taupenot, L., Mahata, S.K., Křen, V., Zídek, V., Fischer, J., Maatz, H., Ziegler, M.G., Pravenec, M., Hubner, N., Aitman, T.J., Schork, N.J., O'Connor, D.T.

“…Understanding catecholamine metabolism is crucial for elucidating the pathogenesis of hereditary hypertension. Here we integrated transcriptional and…”
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