Search Results - "PRATT, Robert M"

Antagonists of the human adenosine A2A receptor. Part 3 Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines by GILLESPIE, Roger J, CLIFFE, Ian A, ROLFEY, Jonathan, STRATTON, Gemma C, UPTON, Rebecca, WEISS, Scott M, WILLIAMSON, Douglas S, DAWSON, Claire E, DOURISH, Colin T, GAUR, Suneel, JORDAN, Allan M, KNIGHT, Antony R, LERPINIERE, Joanne, MISRA, Anil, PRATT, Robert M

“…A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective…”
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Antagonists of the human adenosine A2A receptor. Part 1 Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives by GILLESPIE, Roger J, ADAMS, David R, JORDAN, Allan M, KNIGHT, Antony R, KNUTSEN, Lars J. S, LAWRENCE, Anthony, LERPINIERE, Joanne, MISRA, Anil, PORTER, Richard H. P, PRATT, Robert M, SHEPHERD, Robin, UPTON, Rebecca, BEBBINGTON, David, WARD, Simon E, WEISS, Scott M, WILLIAMSON, Douglas S, BENWELL, Karen, CLIFFE, Ian A, DAWSON, Claire E, DOURISH, Colin T, FLETCHER, Allan, GAUR, Suneel, GILES, Paul R

“…The (-)-(11R,2'S)-enantiomer of the antimalarial drug mefloquine has been found to be a reasonably potent and moderately selective adenosine A(2A) receptor…”
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Antagonists of the human adenosine A2A receptor. Part 2 Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives by GILLESPIE, Roger J, CLIFFE, Ian A, MISRA, Anil, PRATT, Robert M, TODD, Richard S, UPTON, Rebecca, WEISS, Scott M, WILLIAMSON, Douglas S, DAWSON, Claire E, DOURISH, Colin T, GAUR, Suneel, GILES, Paul R, JORDAN, Allan M, KNIGHT, Antony R, LAWRENCE, Anthony, LERPINIERE, Joanne

“…We describe herein the discovery and development of a series of 4-arylthieno[3,2-d]pyrimidines which are potent adenosine A(2A) receptor antagonists. These…”
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Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts by Olden, K, Pratt, R M, Yamada, K M

“…Using tunicamycin, we have investigated the role of glycosylation in the biosynthesis, processing and turnover of CSP, the major cell surface glycoprotein of…”
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Detection of Epidermal Growth Factor-Urogastrone and Its Receptor during Fetal Mouse Development by Nexø, Ebba, Hollenberg, Morley D., Figueroa, Alvaro, Pratt, Robert M.

“…Using both a radioimmunoassay and a radioreceptor assay, we have estimated the content of mouse epidermal growth factor-urogastrone (EGF-URO) in fetal mice at…”
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Mesenchymal Cells from the Human Embryonic Palate are Highly Responsive to Epidermal Growth Factor by Yoneda, Toshiyuki, Pratt, Robert M.

“…An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth,…”
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EGF receptor expression in the developing tooth is altered by exogenous retinoic acid and EGF by Abbott, B.D., Pratt, Robert M.

“…Retinoic acid (RA) is a teratogen producing a variety of malformations including clefts of the secondary palate and malformations of the teeth. Recent studies…”
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Developmental aspects of secondary palate formation by Greene, R M, Pratt, R M

“…Research on development of the secondary palate has, in the past, dealt primarily with morphological aspects of shelf elevation and fusion. The many factors…”
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Inhibition of limb chondrogenesis in vitro by vitamin A: Alterations in cell surface characteristics by Lewis, Cindy Arey, Pratt, Robert M., Pennypacker, John P., Hassell, John R.

“…Mesenchyme cells derived from embryonic mouse limb buds were cultured at high cell density. During the first 24 h in culture, groups of mesenchyme cells…”
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Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis by PRATT, ROBERT M, PASTAN, IRA

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Effect of epidermal growth factor on secondary palatal epithelium in vitro: tissue isolation and recombination studies by Tyler, M S, Pratt, R M

“…Previous studies have shown that epidermal growth factor (EGF), a peptide of m.w. 6045, can specifically inhibit in organ culture the cessation of DNA…”
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Evaluation of murine placental degradation and transfer of [125I]iodo-epidermal growth factor by DiAugustine, R P, Rosch, M J, Lannon, D E, Walker, M P, Pratt, R M

“…Since epidermal growth factor (EGF) has been postulated to play a role in embryonic and fetal growth, a study was undertaken to assess the placental…”
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Undersulfated chondroitin sulfate in the cartilage matrix of brachymorphic mice by Orkin, Roslyn W., Pratt, Robert M., Martin, George R.

“…Homozygous brachymorphic ( bm bm ) mice have a disproportionately short stature, similar to human achondroplasia. We previously showed that each zone of growth…”
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Inhibition of growth in vitro by glucocorticoids in mouse embryonic facial mesenchyme cells by Salomon, D S, Pratt, R M

“…The growth of primary embryonic facial mesenchyme cells established from cleft palate sensitive A/J and resistant C57BL/6J (C57) mice is inhibited by…”
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Glucocorticoid receptors in murine embryonic facial mesenchyme cells by SALOMON, DAVID S, PRATT, ROBERT M

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Tunicamycin inhibits mouse tooth morphogenesis and odontoblast differentiation in vitro by Thesleff, I, Pratt, R M

“…Tunicamycin (TM), an antibiotic that selectively inhibits dolichol-mediated protein glycosylation, inhibited morphogenesis and differentiation of odontoblasts…”
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Dexamethasone affects phosphatidylinositol synthesis and degradation in cultured human embryonic cells by Grove, R I, Willis, W D, Pratt, R M

“…Dexamethasone (DEX), a glucocorticoid which induces cleft palate, causes marked alterations in the synthesis and degradation of phosphatidylinositol (PI) but…”
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Effect of retinoids on proliferation of human embryonic palatal mesenchymal cells in culture by Watanabe, T. (Yamagata Univ. (Japan). School of Medicine), Willis, W.D, Pratt, R.M

“…The cytokinetics and growth effects of retinnic acid (RA) (13-cis-RA, and all-trans-RA) were determined in human embryonic palatal mesenchymal (HEPM) cells…”
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Defective PAPS-synthesis in epiphyseal cartilage from brachymorphic mice by Schwartz, N B, Ostrowski, V, Brown, K S, Pratt, R M

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Immunohistochemical localization of cyclic AMP in the developing rodent secondary palate by Greene, R M, Shanfeld, J L, Davidovitch, Z, Pratt, R M

“…During development of the mammalian secondary palate, medial-edge epithelia (MEE) from apposing palatal shelves adhere and undergo autolysis allowing palatal…”
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