Search Results - "PRATHEESHKUMAR, POYIL"

Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways by Pratheeshkumar, Poyil, Budhraja, Amit, Son, Young-Ok, Wang, Xin, Zhang, Zhuo, Ding, Songze, Wang, Lei, Hitron, Andrew, Lee, Jeong-Chae, Xu, Mei, Chen, Gang, Luo, Jia, Shi, Xianglin

“…Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the growing tumor to receive oxygen and nutrients. Cancer prevention…”
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Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells by Zhang, Zhuo, Pratheeshkumar, Poyil, Budhraja, Amit, Son, Young-Ok, Kim, Donghern, Shi, Xianglin

“…[Display omitted] •Short term exposure of cells to arsenic causes ROS generation.•Chronical exposure of cells to arsenic causes malignant cell…”
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Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells by Son, Young-Ok, Pratheeshkumar, Poyil, Divya, Sasidharan Padmaja, Zhang, Zhuo, Shi, Xianglin

“…Nickel-containing compounds are widely used in industry. Nickel is a known human carcinogen that primarily affects the lungs. Proposed mechanisms of…”
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Cancer prevention with promising natural products: mechanisms of action and molecular targets by Pratheeshkumar, Poyil, Sreekala, Chakkenchath, Zhang, Zhuo, Budhraja, Amit, Ding, Songze, Son, Young-Ok, Wang, Xin, Hitron, Andrew, Hyun-Jung, Kim, Wang, Lei, Lee, Jeong-Chae, Shi, Xianglin

“…Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural…”
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Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways by Pratheeshkumar, Poyil, Son, Young-Ok, Divya, Sasidharan Padmaja, Roy, Ram Vinod, Hitron, John Andrew, Wang, Lei, Kim, Donghern, Dai, Jin, Asha, Padmaja, Zhang, Zhuo, Wang, Yitao, Shi, Xianglin

“…Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with the incidence of lung cancer. Inhibition of metal induced carcinogenesis by a…”
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Quercitrin protects skin from UVB-induced oxidative damage by Yin, Yuanqin, Li, Wenqi, Son, Young-Ok, Sun, Lijuan, Lu, Jian, Kim, Donghern, Wang, Xin, Yao, Hua, Wang, Lei, Pratheeshkumar, Poyil, Hitron, Andrew J., Luo, Jia, Gao, Ning, Shi, Xianglin, Zhang, Zhuo

“…Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally…”
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Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis by Pratheeshkumar, Poyil, Son, Young-Ok, Budhraja, Amit, Wang, Xin, Ding, Songze, Wang, Lei, Hitron, Andrew, Lee, Jeong-Chae, Kim, Donghern, Divya, Sasidharan Padmaja, Chen, Gang, Zhang, Zhuo, Luo, Jia, Shi, Xianglin

“…Angiogenesis, the formation of new blood vessels from pre-existing vascular beds, is essential for tumor growth, invasion, and metastasis. Luteolin is a common…”
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XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis by Hussain, Azhar R, Siraj, Abdul Khalid, Ahmed, Maqbool, Bu, Rong, Pratheeshkumar, Poyil, Alrashed, Alanood M, Qadri, Zeeshan, Ajarim, Dahish, Al-Dayel, Fouad, Beg, Shaham, Al-Kuraya, Khawla S

“…Breast cancer is the most common cancer in females and is ranked second in cancer-related deaths all over the world in women. Despite improvement in diagnosis,…”
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CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells by Pratheeshkumar, Poyil, Siraj, Abdul K, Divya, Sasidharan Padmaja, Parvathareddy, Sandeep Kumar, Alobaisi, Khadija, Al-Sobhi, Saif S, Al-Dayel, Fouad, Al-Kuraya, Khawla S

“…Chromodomain-helicase-DNA-binding protein 4 (CHD4), a core subunit of the nucleosome remodeling and deacetylation (NuRD) complex is highly expressed in several…”
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Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis by Son, Young-Ok, Pratheeshkumar, Poyil, Roy, Ram Vinod, Hitron, John Andrew, Wang, Lei, Divya, Sasidharan Padmaja, Xu, Mei, Luo, Jia, Chen, Gang, Zhang, Zhuo, Shi, Xianglin

“…Arsenic (As3+) is a carcinogen with considerable environmental and occupational relevancy. The present study shows that As3+-transformed human lung bronchial…”
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Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling by Pratheeshkumar, Poyil, Son, Young-Ok, Divya, Sasidharan Padmaja, Turcios, Lilia, Roy, Ram Vinod, Hitron, John Andrew, Wang, Lei, Kim, Donghern, Dai, Jin, Asha, Padmaja, Zhang, Zhuo, Shi, Xianglin

“…Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with an increased risk of lung cancer. However, the mechanisms underlying…”
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APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy by Siraj, Abdul K., Kumar Parvathareddy, Sandeep, Pratheeshkumar, Poyil, Padmaja Divya, Sasidharan, Ahmed, Saeeda Omer, Melosantos, Roxanne, Begum, Rafia, Concepcion, Rica Micaela J.A., Al-Sanea, Nasser, Ashari, Luai H, Abduljabbar, Alaa, Al-Dayel, Fouad, Al-Kuraya, Khawla S.

“…[Display omitted] •In Saudi Arabia, CRC is the second most common cancer.•In our cohort, APC mutation was independent predictor of superior overall…”
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Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation by Wang, Lei, Fan, Jia, Hitron, John Andrew, Son, Young-Ok, Wise, James T F, Roy, Ram Vinod, Kim, Donghern, Dai, Jin, Pratheeshkumar, Poyil, Zhang, Zhuo, Shi, Xianglin

“…Nickel compounds are known as human carcinogens. Chronic environmental exposure to nickel is a worldwide health concern. Although the mechanisms of…”
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Krupple-Like Factor 5 is a Potential Therapeutic Target and Prognostic Marker in Epithelial Ovarian Cancer by Siraj, Abdul K, Pratheeshkumar, Poyil, Divya, Sasidharan Padmaja, Parvathareddy, Sandeep Kumar, Alobaisi, Khadija A, Thangavel, Saravanan, Siraj, Sarah, Al-Badawi, Ismail A, Al-Dayel, Fouad, Al-Kuraya, Khawla S

“…Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. Despite current therapeutic and surgical options, advanced EOC shows poor…”
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Epithelial–mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells by Ding, Song-Ze, Yang, Yu-Xiu, Li, Xiu-Ling, Michelli-Rivera, Audrey, Han, Shuang-Yin, Wang, Lei, Pratheeshkumar, Poyil, Wang, Xin, Lu, Jian, Yin, Yuan-Qin, Budhraja, Amit, Hitron, Andrew J.

“…Hexavalent chromium [Cr(VI)] is an important human carcinogen associated with pulmonary diseases and lung cancer. Exposure to Cr(VI) induces DNA damage, cell…”
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RETRACTED ARTICLE: Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism by Pratheeshkumar, Poyil, Son, Young-Ok, Divya, Sasidharan Padmaja, Wang, Lei, Zhang, Zhuo, Shi, Xianglin

“…Arsenic is a well-documented human carcinogen. The present study explored the role of the onco-miR, miR-21 and its target protein, programmed cell death 4…”
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Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression by Wang, Lei, Kuang, Lisha, Hitron, John Andrew, Son, Young-Ok, Wang, Xin, Budhraja, Amit, Lee, Jeong-Chae, Pratheeshkumar, Poyil, Chen, Gang, Zhang, Zhuo, Luo, Jia, Shi, Xianglin

“…Environmental exposure to arsenic is known to cause various cancers. There are some potential relationships between cell malignant transformation and C-X-C…”
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Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis by Roy, Ram Vinod, Son, Young-Ok, Pratheeshkumar, Poyil, Wang, Lei, Hitron, John Andrew, Divya, Sasidharan Padmaja, D, Rakesh, Kim, Donghern, Yin, Yuanqin, Zhang, Zhuo, Shi, Xianglin

“…DNA methylation and histone modification promote opening and closure of chromatin structure, which affects gene expression without altering the DNA sequence…”
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Abstract 2798: Quercetin inhibits Cr(VI)-induced malignant transformation of human lung epithelial cells by targeting miR-21-Pdcd4 signaling pathway by Poyil, Pratheeshkumar

“…Hexavalent chromium [Cr(VI)] is an important human carcinogen associated with pulmonary diseases and lung cancer. Cancer prevention using natural products has…”
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Oxidative stress and metal carcinogenesis by Lee, Jeong-Chae, Son, Young-Ok, Pratheeshkumar, Poyil, Shi, Xianglin

“…Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals…”
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