Search Results - "PRASAD, G. L"

Part three: a randomized study to assess biomarker changes in cigarette smokers switched to Vuse Solo or Abstinence by Kanobe, Milly N., Jones, Bobbette A., Nelson, Paul, Brown, Buddy G., Chen, Peter, Makena, Patrudu, Schmidt, Eckhardt, Darnell, John, Caraway, John W., Prasad, G. L., Nordskog, Brian, Round, Elaine K.

“…Biomarkers of exposure (BoE) can help evaluate exposure to combustion-related, tobacco-specific toxicants after smokers switch from cigarettes to potentially…”
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Differential gene expression of 3D primary human airway cultures exposed to cigarette smoke and electronic nicotine delivery system (ENDS) preparations by Rayner, Rachael E, Makena, Patrudu, Liu, Gang, Prasad, G L, Cormet-Boyaka, Estelle

“…Acute exposure to cigarette smoke alters gene expression in several biological pathways such as apoptosis, immune response, tumorigenesis and stress response,…”
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Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke by Zhang, Yao, Geng, Shuo, Prasad, G L, Li, Liwu

“…Chronic cigarette smoking is widely known to alter immune functions and compromise host defense against microbial infection. Neutrophils play an essential role…”
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Pathway Analysis of Global Metabolomic Profiles Identified Enrichment of Caffeine, Energy, and Arginine Metabolism in Smokers but Not Moist Snuff Consumers by Liu, Gang, Lee, Douglas P, Schmidt, Eckhardt, Prasad, GL

“…Existing US epidemiological data demonstrate that consumption of smokeless tobacco, particularly moist snuff, is less harmful than cigarette smoking. However,…”
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Distinct gene expression changes in human peripheral blood mononuclear cells treated with different tobacco product preparations by Arimilli, Subhashini, Makena, Patrudu, Liu, Gang, Prasad, G.L.

“…Cigarette smoking exerts diverse physiological effects including immune suppression. To better characterize the biological effects of different categories of…”
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Resensitization of breast cancer cells to anoikis by Tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion by BHARADWAJ, Shantaram, THANAWALA, Ruchi, BON, Giulia, FALCIONI, Rita, PRASAD, G. L

“…Two most common properties of malignant cells are the presence of aberrant actin cytoskeleton and resistance to anoikis. Suppression of several key…”
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Regulation of gene expression by tobacco product preparations in cultured human dermal fibroblasts by Malpass, Gloria E., Arimilli, Subhashini, Prasad, G.L., Howlett, Allyn C.

“…Skin fibroblasts comprise the first barrier of defense against wounds, and tobacco products directly contact the oral cavity. Cultured human dermal fibroblasts…”
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Outcomes of developmental exposure to total particulate matter from cigarette smoke in zebrafish (Danio rerio) by Massarsky, Andrey, Jayasundara, Nishad, Glazer, Lilah, Levin, Edward D., Prasad, G.L., Di Giulio, Richard T.

“…•Effects of prenatal exposure to cigarette smoke remain a subject of major interest.•Effects of developmental exposure to total particulate matter (TPM) were…”
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Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors by RAVAL, Gira N, BHARADWAJ, Shantaram, LEVINE, Edward A, WILLINGHAM, Mark C, GEARY, Randolph L, KUTE, Tim, PRASAD, G. L

“…Suppression of tropomyosins (TMs), a family of actin-binding, microfilament-associated proteins, is a prominent feature of many transformed cells. Yet it is…”
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Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells by Bharadwaj, Shantaram, Prasad, G.L

“…Tropomyosins (TMs) are a family of microfilament binding proteins, which are suppressed in the transformed cells. We have investigated the mechanism of…”
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The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans by Bodhicharla, Rakesh, Ryde, Ian T., Prasad, G.L., Meyer, Joel N.

“…The metabolites of the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) form DNA adducts in animal models. While there are…”
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Gene expression profiles associated with cigarette smoking and moist snuff consumption by Arimilli, Subhashini, Madahian, Behrouz, Chen, Peter, Marano, Kristin, Prasad, G L

“…Among the different tobacco products that are available on the US market, cigarette smoking is shown to be the most harmful and the effects of cigarette…”
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Cigarette smoke preparations, not electronic nicotine delivery system preparations, induce features of lung disease in a 3D lung repeat-dose model by Rayner, Rachael E, Makena, Patrudu, Prasad, G L, Cormet-Boyaka, Estelle

“…Cigarette smoking is a risk factor for several lung diseases, including chronic obstructive pulmonary disease, cardiovascular disease, and lung cancer. The…”
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Metabolomic Analysis Identified Reduced Levels of Xenobiotics, Oxidative Stress, and Improved Vitamin Metabolism in Smokers Switched to Vuse Electronic Nicotine Delivery System by Liu, Gang, Lin, Chi Jen, Yates, Charles R, Prasad, G L

“…Abstract Introduction Switching to noncombustible tobacco products presents an opportunity for cigarette smokers to potentially reduce the health risks…”
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Cigarette smoke preparations, not moist snuff, impair expression of genes involved in immune signaling and cytolytic functions by Liu, Gang, Arimilli, Subhashini, Savage, Evan, Prasad, G. L.

“…Cigarette smoke-induced chronic inflammation is associated with compromised immune responses. To understand how tobacco products impact immune responses, we…”
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Urinary Leukotriene E 4 and 2,3-Dinor Thromboxane B 2 Are Biomarkers of Potential Harm in Short-Term Tobacco Switching Studies by Makena, Patrudu, Liu, Gang, Chen, Peter, Yates, Charles R, Prasad, G L

“…Modified risk tobacco products (MRTP) can reduce harm by decreasing exposure to combustion-related toxicants. In the absence of epidemiologic data, biomarkers…”
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Urinary Leukotriene E4 and 2,3-Dinor Thromboxane B2 Are Biomarkers of Potential Harm in Short-Term Tobacco Switching Studies by Makena, Patrudu, Liu, Gang, Chen, Peter, Yates, Charles R., Prasad, G.L.

“…Abstract Background: Modified risk tobacco products (MRTP) can reduce harm by decreasing exposure to combustion-related toxicants. In the absence of…”
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Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio) by Massarsky, Andrey, Prasad, G.L., Di Giulio, Richard T.

“…Several studies have demonstrated zebrafish as a useful high-throughput in vivo model to study the effects of cigarette smoke on early development. It has been…”
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Differences in biomarkers of inflammation and immune responses in chronic smokers and moist snuff users by Tran, Quynh T., Arimilli, Subhashini, Scott, Eric, Chen, Peter, Prasad, G.L.

“…[Display omitted] •Toxicants in cigarette smoke are drivers of smoking-related diseases such as cancer.•Cigarette smoking impacts systemic immune responses,…”
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Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation : Evidence for Rho kinase pathway by SHAH, Vanya, BHARADWAJ, Shantaram, KAIBUCHI, Kozo, PRASAD, G. L

“…Tropomyosin (TM) family of cytoskeletal proteins is implicated in stabilizing actin microfilaments. Many TM isoforms, including tropomyosin-1 (TM1), are…”
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