Search Results - "PRAGER, R. H"

Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes by Hart, P H, Brand, C, Carson, C F, Riley, T V, Prager, R H, Finlay-Jones, J J

“…To evaluate potential antiinflammatory properties of tea tree oil, the essential oil steam distilled from the Australian native plant, Melaleuca alternifolia…”
Get full text

The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro by Brand, C, Ferrante, A, Prager, R H, Riley, T V, Carson, C F, Finlay-Jones, J J, Hart, P H

“…To evaluate the regulatory properties of the essential oil of Melaleuca alternifolia (tea tree oil) on the production of oxygen derived reactive species by…”
Get full text

Phaclofen: a peripheral and central baclofen antagonist by Kerr, D I, Ong, J, Prager, R H, Gynther, B D, Curtis, D R

“…Phaclofen, the phosphonic acid derivative of baclofen, reversibly antagonized the depression of the cholinergic twitch response of the guinea pig ileum and…”
Get more information

2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors by Kerr, D I, Ong, J, Johnston, G A, Abbenante, J, Prager, R H

“…2-hydroxy-saclofen (2-OH-S), a sulphonic analogue of baclofen, slightly increased the twitch height and reversibly antagonised the GABA- and baclofen-induced…”
Get more information

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen by Lambert, N A, Harrison, N L, Kerr, D I, Ong, J, Prager, R H, Teyler, T J

“…The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potential from CA1 hippocampal neurons…”
Get more information

Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord by Curtis, D R, Gynther, B D, Beattie, D T, Kerr, D I, Prager, R H

“…When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly…”
Get more information

Differing actions of nitropropane analogs of GABA and baclofen in central and peripheral preparations by Ong, J, Kerr, D I, Lacey, G, Curtis, D R, Hughes, R, Prager, R H

“…In the guinea-pig isolated ileum, both baclofen (5-100 microM) and gamma-aminobutyric acid (GABA; 5-100 microM) induced a bicuculline-insensitive depression of…”
Get more information

Precursors to Damascenone:  Synthesis and Hydrolysis of Isomeric 3,9-Dihydroxymegastigma-4,6,7-trienes by Puglisi, Carolyn J, Daniel, Merran A, Capone, Dimitra L, Elsey, Gordon M, Prager, Rolf H, Sefton, Mark A

“…A series of four isomeric 3,9-dihydroxymegastigma-4,6,7-trienes, 8, has been prepared. The (3S,6R,9S) isomer of 8 proved to be identical to an isomer of this…”
Get full text

Rates of Formation of cis- and trans-Oak Lactone from 3-Methyl-4-hydroxyoctanoic Acid by Wilkinson, Kerry L, Elsey, Gordon M, Prager, Rolf H, Pollnitz, Alan P, Sefton, Mark A

“…The rates of formation of both cis- and trans-oak lactone from the corresponding isomers of 3-methyl-4-hydroxyoctanoic acid have been measured in model wine at…”
Get full text

GABAB-receptor-mediated actions of baclofen in rat isolated neocortical slice preparations: antagonism by phosphono-analogues of GABA by Kerr, D I, Ong, J, Johnston, G A, Prager, R H

“…Baclofen, 3-amino-propylphosphonic acid (3-APPA), and beta-phenyl-GABA (BPG), each reduced the frequency of spontaneous paroxysmal discharges in rat…”
Get more information

Antagonism of GABAB‐receptor‐mediated responses in the guinea‐pig isolated ileum and vas deferens by phosphono‐analogues of GABA by Kerr, David I.B., Ong, Jennifer, Prager, Rolf H.

“…1 The phosphono‐analogues of γ‐aminobutyric acid (GABA), 4‐amino‐butylphosphonic acid (4‐ABPA), 3‐amino‐2‐(4‐chlorophenyl)‐propylphosphonic acid (phaclofen)…”
Get full text

Synthesis, formulation, and clinical pharmacological evaluation of hydralazine pyruvic acid hydrazone in two healthy volunteers by Reece, P A, Stafford, I, Prager, R H, Walker, G J, Zacest, R

“…Hydralazine pyruvic acid hydrazone [2-(phthalazin-1-yl hydrazono)propionic acid; 1] is a major plasma metabolite of hydralazine in humans. A number of in vitro…”
Get more information

3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations by KERR, D. I. B, ONG, J, HUGHES, R, PRAGER, R. H

“…Racemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the…”
Get full text

The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations by KERR, D. I. B, ONG, J, DOOLETTE, D. J, SCHAFER, K, PRAGER, R. H

“…In the guinea-pig isolated ileum, (RS)-(+/-)-baclofen induced a depression of cholinergic twitch contractions, reversibly and competitively antagonised by…”
Get full text

3-amino-2-(4-chlorophenyl)-nitropropane is a new GABAB receptor agonist, more active peripherally by Kerr, D I, Ong, J, Doolette, D J, Abbenante, J, Prager, R H

“…The activity of the nitropropane analog of baclofen, 3-amino-2-(4-chlorophenyl)-nitropropane (N-BAC), has been examined at central and peripheral GABAB…”
Get more information

Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA by Kerr, D I, Ong, J, Johnston, G A, Abbenante, J, Prager, R H

“…Saclofen (the direct sulphonic analogue of baclofen) is a competitive antagonist of baclofen at GABAB receptors in guinea pig ileum and rat cortical slices…”
Get more information

Differential modulation of gamma-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant or convulsant activity by Skerritt, J H, Johnston, G A, Chow, S C, MacDonald, R L, Prager, R H, Ward, A D

“…The effects of a series of caprolactam derivatives with central depressant, convulsant or muscle relaxant activity were investigated upon gamma-aminobutyric…”
Get more information

Carbene and radical pathways in pyrolysis of benzisoxazolones and benzotriazoles by Prager, Rolf H., Baradarani, Mehdi M., Khalafy, Jabbar

“…A comparative study of the flash vacuum pyrolysis of a number of N‐alkyl and N‐acyl benzotriazoles and benzisoxazolones has confirmed that carbene derived…”
Get full text

Short-chain baclofen analogues are GABAB receptor antagonists in the guinea-pig isolated ileum by Ong, J, Kerr, D I, Abbenante, J, Prager, R H

“…A new series of GABAB receptor antagonists, based on short-chain baclofen analogues has been investigated. In guinea-pig isolated ileal preparations, the GABAB…”
Get more information

Evaluation of 3-aminopropanesulphonamide analogues of GABA as antagonists at GABA(B) receptors in peripheral and central preparations by Ong, J, Kerr, D I, Bowden, J C, Prager, R H

“…Cholinergic twitch responses in the guinea-pig isolated ileum, and spontaneous discharges in rat neocortical slices, were depressed by the GABA(B) receptor…”
Get full text