Search Results - "POWLES, R. L"

A study to determine the safety profile and maximum tolerated dose of micafungin (FK463) in patients undergoing haematopoietic stem cell transplantation by SIROHI, B, POWLES, R. L, CHOPRA, R, RUSSELL, N, BYRNE, J. L, PRENTICE, H. G, POTTER, M, KOBLINGER, S

“…This open-label, dose-escalation study assessed the maximum tolerated dose (MTD) of the new antifungal micafungin in patients undergoing haematopoietic stem…”
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Syngeneic transplantation in multiple myeloma: a case-matched comparison with autologous and allogeneic transplantation by GAHRTON, G, SVENSSON, H, GUILHOT, F, LAMBERTENGHI DELILIERS, G, LJUNGMAN, P, MASSZI, T, MILLIGAN, D. W, POWLES, R. L, REIFFERS, J, SAMSON, J. D, STOPPA, A. M, VERNANT, J. P, BJÖRKSTRAND, B, VOLIN, L, WALLVIK, J, APPERLEY, J, CARLSON, K, CAVO, M, FERRANT, A, FOUILLARD, L, GRATECOS, N, GRATWOHL, A

“…Twenty-five patients with multiple myeloma received bone marrow grafts (n = 24) or peripheral blood stem cells (n = 1) from twin donors. The outcome was…”
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Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia ? by RINGDEN, O, HOROWITZ, M. M, RIMM, A. A, ROZMAN, C, SOBOCINSKI, K. A, SPECK, B, ZWAAN, F. E, BORTIN, M. M, SONDEL, P, GALE, R. P, BIGGS, J. C, CHAMPLIN, R. E, DEEG, H. J, DICKE, K, MASAOKA, T, POWLES, R. L

“…Optimal prophylaxis of graft-versus-host disease (GVHD) is controversial. We compared efficacy of three posttransplant immune suppressive regimens in 2,286…”
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Long-term survival in allogeneic bone marrow transplant recipients following acyclovir prophylaxis for CMV infection by PRENTICE, H. G, GLUCKMAN, E, POWLES, R. L, LJUNGMAN, P, MILPIED, N. J, CAMARA, R, MANDELLI, F, KHO, P, KENNEDY, L, BELL, A. R

“…Recipients of HLA-matched, related or unrelated allogeneic BMT who were CMV seropositive or those receiving unmanipulated marrow from a seropositive donor were…”
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Vaginal stenosis following allogeneic bone marrow transplantation for acute myeloid leukaemia by DELORD, C, TRELEAVEN, J, SHEPHERD, J, SASO, R, POWLES, R. L

“…We report the unusual complication of vaginal stenosis occurring after allogeneic bone marrow transplantation (BMT) for leukaemia. This was in all likelihood a…”
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Recombinant tissue plasminogen activator (rtPA) for the treatment of hepatic veno-occlusive disease (VOD) by KULKARNI, S, RODRIGUEZ, M, LAFUENTE, A, MATEOS, P, MEHTA, J, SINGHAL, S, SASO, R, TAIT, D, TRELEAVEN, J. G, POWLES, R. L

“…Seventeen patients who developed hepatic veno-occlusive disease (VOD) following hematopoietic stem cell transplantation were treated with recombinant tissue…”
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Impact of previous high-dose therapy on outcome after allografting for multiple myeloma by KULKARNI, S, POWLES, R. L, TRELEAVEN, J. G, SINGHAL, S, SASO, R, HORTON, C, KILLICK, S, TAIT, D, RAMIAH, V, MEHTA, J

“…We describe a single centre experience of 33 patients allografted for multiple myeloma, of which 28 received matched sibling marrow, one haploidentical family…”
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Additional chromosome abnormalities confer worse prognosis in acute promyelocytic leukaemia by HIORNS, LYNNE R., SWANSBURY, G. JOHN, MEHTA, JAYESH, MIN, TOON, DAINTON, MELISSA G., TRELEAVEN, JENNIE, POWLES, RAYMOND L., CATOVSKY, DANIEL

“…Acute promyelocytic leukaemia (APL) has been associated with a favourable prognosis in many studies of acute myeloid leukaemia. A series of 54 patients treated…”
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The importance of CD34+/CD33- cells in platelet engraftment after intensive therapy for cancer patients given peripheral blood stem cell rescue by MILLAR, B. C, MILLAR, J. L, SHEPHERD, V, BLACKWELL, P, PORTER, H, CUNNINGHAM, D, JUDSON, I, TRELEAVEN, J, POWLES, R. L, CATOVSKY, D

“…The study was designed to determine whether the number of CD34+/CD33- cells given at autologous peripheral blood stem cell (PBSC) rescue after intensive…”
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Early detection of cytomegalovirus (CMV) infection in bone marrow transplant patients by reverse transcription-PCR for CMV spliced late gene UL21.5: a two site evaluation by Boriskin, Yu.S., Fuller, K., Powles, R.L., Vipond, I.B., Rice, P.S., Booth, J.C., Caul, E.O., Butcher, P.D.

“…Background: Bone marrow transplant (BMT) patients at risk of developing cytomegalovirus (CMV) pneumonitis are identified routinely by the early detection of…”
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Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice by Clutterbuck, Robyn D., Millar, Barbara C., Powles, Ray L., Newman, Ann, Catovsky, Daniel, Jarman, Michael, Millar, John L.

“…SCID mice were inoculated intravenously with cells from the human HL60 myeloblastic leukaemia cell line and then treated with the 3‐hydroxy‐3‐methylglutaryl…”
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Detection of minimal residual disease in B‐lineage acute lymphoblastic leukaemia by quantitative flow cytometry by Farahat, Nahla, Morilla, Alison, Owusu‐Ankomah, Kwasi, Morilla, Ricardo, Pinkerton, C. Ross, Treleaven, Jennie G., Matutes, Estella, Powles, Ray L., Catovsky, Daniel

“…The clinical significance of detecting minimal residual disease (MRD) in B‐lineage acute lymphoblastic leukaemia (ALL) was evaluated by quantitative flow…”
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Deletions and Rearrangement of CDKN2 in Lymphoid Malignancy by Stranks, G., Height, S.E., Mitchell, P., Jadayel, D., Yuille, M.A.R., De Lord, C., Clutterbuck, R.D., Treleaven, J.G., Powles, R.L., Nacheva, E., Oscier, D.G., Karpas, A., Lenoir, G.M., Smith, S.D., Millar, J.L., Catovsky, D., Dyer, M.J.S.

“…Recurrent abnormalities of the short arm of chromosome 9, including translocations and interstitial deletions, have been reported in both leukemia and…”
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Topical issues in unrelated donor haematopoietic stem cell transplants: a report from a workshop convened by the Anthony Nolan Trust in London - 2005 by Duarte, R F, Pamphilon, D, Cornish, J, Shaw, B E, Samson, D, Craddock, C, Marks, D, Mufti, G J, Powles, R L, Apperley, J F, Madrigal, J A, Goldman, J M

“…Over more than three decades, The Anthony Nolan Trust (ANT) has provided an unrelated donor (UD) for over 4000 children and adults lacking a suitable family…”
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Multiple myeloma treated with high dose intravenous melphalan by Selby, P J, McElwain, T J, Nandi, A C, Perren, T J, Powles, R L, Tillyer, C R, Osborne, R J, Slevin, M L, Malpas, J S

“…High dose melphalan (HDM, 140 mg/m2 i.v.) has been evaluated in 58 patients under 63 years with multiple myeloma. Among previously untreated patients 11/41…”
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The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation by SELBY, P. J, POWLES, R. L, EASTON, D, PERREN, T. J, STOLLE, K, JKAMESON, B, FIDDIAN, A. P, TRYHORN, Y, STERN, H

“…Eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6…”
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GM-CSF accelerates neutrophil recovery after autologous hematopoietic stem cell transplantation by Greenberg, P, Advani, R, Keating, A, Gulati, S C, Nimer, S, Champlin, R, Karanes, C, Gorin, N C, Powles, R L, Smith, A, Lamborn, K, Cuffie, C

“…Patients with non-myeloid hematologic malignancies (including Hodgkin's and non-Hodgkin's lymphomas, myeloma and acute lymphoid leukemia) or solid tumors…”
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Fatal pneumococcal infections following allogeneic bone marrow transplant by Rege, K, Mehta, J, Treleaven, J, Jameson, B, Meller, S T, Mitchell, P, Milan, S, Powles, R L

“…Six cases of fatal pneumococcal sepsis are described, occurring in the post-allograft setting, between 3 and 39 months after transplantation. Five of the six…”
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Systemic candidiasis with candida vasculitis due to Candida kruzei in a patient with acute myeloid leukaemia by GREGORY, R. K, POWLES, R. L, TRELEAVEN, J. G, SMITH, M. L, MORTIMER, P. S, WOTHERSPOON, A, RILEY, U

“…Candida kruzei-related systemic infections are increasing in frequency, particularly in patients receiving prophylaxis with antifungal triazoles. A Caucasian…”
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Selective inhibition of primary acute myeloid leukaemia cell growth by lovastatin by Newman, A, Clutterbuck, R D, Powles, R L, Millar, J L

“…Primary human acute myeloid leukaemic (AML) cells from bone marrow (BM) and peripheral blood (PB), the human myeloblastic leukaemia cell line (HL60) and normal…”
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