Search Results - "POWIS, G"

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes by Zhu, Jingjing, Powis de Tenbossche, Céline G., Cané, Stefania, Colau, Didier, van Baren, Nicolas, Lurquin, Christophe, Schmitt-Verhulst, Anne-Marie, Liljeström, Peter, Uyttenhove, Catherine, Van den Eynde, Benoit J.

“…Despite impressive clinical success, cancer immunotherapy based on immune checkpoint blockade remains ineffective in many patients due to tumoral resistance…”
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A revisited history of cacao domestication in pre-Columbian times revealed by archaeogenomic approaches by Lanaud, Claire, Vignes, Hélène, Utge, José, Valette, Gilles, Rhoné, Bénédicte, Garcia Caputi, Mariella, Angarita Nieto, Natalia Sofía, Fouet, Olivier, Gaikwad, Nilesh, Zarrillo, Sonia, Powis, Terry G., Cyphers, Ann, Valdez, Francisco, Olivera Nunez, S. Quirino, Speller, Camilla, Blake, Michael, Valdez, Fred Jr, Raymond, Scott, Rowe, Sarah M., Duke, Guy S., Romano, Francisco Ernesto, Loor Solórzano, Rey Gaston, Argout, Xavier

“…Humans have a long history of transporting and trading plants, contributing to the evolution of domesticated plants. Theobroma cacao originated in the…”
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Cacao use and the San Lorenzo Olmec by Powis, Terry G, Cyphers, Ann, Gaikwad, Nilesh W, Grivetti, Louis, Cheong, Kong

“…Mesoamerican peoples had a long history of cacao use--spanning more than 34 centuries--as confirmed by previous identification of cacao residues on…”
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PATHOME: an algorithm for accurately detecting differentially expressed subpathways by Nam, S, Chang, H R, Kim, K-T, Kook, M-C, Hong, D, Kwon, C H, Jung, H R, Park, H S, Powis, G, Liang, H, Park, T, Kim, Y H

“…The translation of high-throughput gene expression data into biologically meaningful information remains a bottleneck. We developed a novel computational…”
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Properties and biological activities of thioredoxins by Powis, G, Montfort, W R

“…The mammalian thioredoxins are a family of small (approximately 12 kDa) redox proteins that undergo NADPH-dependent reduction by thioredoxin reductase and in…”
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Prehispanic use of chili peppers in Chiapas, Mexico by Powis, Terry G, Gallaga Murrieta, Emiliano, Lesure, Richard, Lopez Bravo, Roberto, Grivetti, Louis, Kucera, Heidi, Gaikwad, Nilesh W

“…The genus Capsicum is New World in origin and represents a complex of a wide variety of both wild and domesticated taxa. Peppers or fruits of Capsicum species…”
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Early Maya Ceremonial Architecture at Pacbitun, Belize by Powis, Terry G., Micheletti, George J., Crow, Kaitlin, Skaggs, Sheldon, Stanchly, Norbert, Cartagena, Nicaela, Powis, Jeffrey A.

“…The development of Middle Preclassic (900–300 BC) ceremonial architecture is receiving more attention by archaeologists conducting research in the Maya…”
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Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma by Koul, Dimpy, Shen, Ruijun, Kim, Yong-Wan, Kondo, Yasuko, Lu, Yiling, Bankson, Jim, Ronen, Sabrina M, Kirkpatrick, D Lynn, Powis, Garth, Yung, W K Alfred

“…The phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway is critical in glioblastomas. Loss of PTEN, a negative regulator of the PI3K pathway or…”
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7 KRAS the Elephant in the Room of Cancer Therapy: New Approaches by Powis, G, Ihle, N.T, Kirkpatrick, D.L

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490 Potent and selective inhibitors of the KRAS-signaling nanocluster protein, CNKSR1, block oncogenic KRAS signaling and mut-KRAS cell growth by Kirkpatrick, L, Triana-Baltzer, G, Indarte, M, Scott, M, Lemos, R, Powis, G

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An Iterative Approach to Ground Penetrating Radar at the Maya Site of Pacbitun, Belize by Skaggs, Sheldon, Powis, Terry G, Rucker, Clara R, Micheletti, George

“…Ground penetrating radar (GPR) surveys provide distinct advantages for archaeological prospection in ancient, complex, urban Maya sites, particularly where…”
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PI-3-Kinase inhibitors in colorectal cancer by Ihle, N T, Powis, G, Kopetz, S

“…Despite recent successes, metastatic colorectal cancer remains a difficult cancer to treat. Since the initial discovery that PI-3-Kinase/AKT signaling played…”
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Minimal tolerance to a tumor antigen encoded by a cancer-germline gene by Huijbers, Ivo J, Soudja, Saïdi M, Uyttenhove, Catherine, Buferne, Michel, Inderberg-Suso, Else-Marit, Colau, Didier, Pilotte, Luc, Powis de Tenbossche, Céline G, Chomez, Patrick, Brasseur, Francis, Schmitt-Verhulst, Anne-Marie, Van den Eynde, Benoît J

“…Central tolerance toward tissue-restricted Ags is considered to rely on ectopic expression in the thymus, which was also observed for tumor Ags encoded by…”
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406 PHT-782 an Inhibitor of the KRAS Signaling Nanocluster Protein CNKSR1 Blocks Oncogenic KRAS Signaling by Ihle, N, Abdelmelek, M.F, Zhang, S, Indarte, M, Kirkpatrick, D.L, Powis, G

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61 Patient-derived Metastatic Colorectal Cancer Mouse Tumorgrafts for Anticancer and Mechanism Studies by Lemos, R, Kopetz, S, Jiang, Z, Dasari, A, Maru, D, Powis, G

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3-(Hydroxymethyl)-Bearing Phosphatidylinositol Ether Lipid Analogues and Carbonate Surrogates Block PI3-K, Akt, and Cancer Cell Growth by Hu, Youhong, Qiao, Lixin, Wang, Shaomeng, Rong, Suo-bao, Meuillet, Emmanuelle J, Berggren, Margareta, Gallegos, Alfred, Powis, Garth, Kozikowski, Alan P

“…Phosphatidylinositol 3-kinase (PI3-K) phosphorylates the 3-position of phosphatidylinositol to give rise to three signaling phospholipids. Binding of the…”
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Thioredoxin reductase and cancer cell growth inhibition by organotellurium compounds that could be selectively incorporated into tumor cells by ENGMAN, Lars, AL-MAHARIK, Nawaf, MCNAUGHTON, Michael, BIRMINGHAM, Anne, POWIS, Garth

“…The thioredoxins are small ubiquitous redox proteins with the conserved redox catalytic sequence-Trp-Cys-Gly-Pro-Cys-Lys, where the Cys residues undergo…”
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Thioredoxin Peroxidase-1 (peroxiredoxin-1) Is Increased in Thioredoxin-1 Transfected Cells and Results in Enhanced Protection against Apoptosis Caused by Hydrogen Peroxide but Not by Other Agents Including Dexamethasone, Etoposide, and Doxorubicin by Berggren, Margareta I., Husbeck, Bryan, Samulitis, Betty, Baker, Amanda F., Gallegos, Alfred, Powis, Garth

“…Thioredoxin-1 (Trx-1) is a small redox oncoprotein whose expression is increased in a number of human primary cancers where it is associated with aggressive…”
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Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth by TOME, Margaret E, BAKER, Amanda F, POWIS, Garth, PAYNE, Claire M, BRIEHL, Margaret M

“…Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid…”
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Signalling pathways as targets for anticancer drug development by Powis, G

“…Intracellular signalling pathways mediating the effects of oncogenes on cell growth and transformation offer novel targets for the development of anticancer…”
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