Search Results - "POWER, DAVID A"

Elevated serum urea-to-creatinine ratio is associated with adverse inpatient clinical outcomes in non-end stage chronic kidney disease by Brookes, Elizabeth M., Power, David A.

“…To better understand the role of the urea-to-creatinine ratio in chronic kidney disease patients, we assessed the epidemiology of the urea-to-creatinine ratio…”
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Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin by Lee, Mardiana, Katerelos, Marina, Gleich, Kurt, Galic, Sandra, Kemp, Bruce E, Mount, Peter F, Power, David A

“…Expression of genes regulating fatty acid metabolism is reduced in tubular epithelial cells from kidneys with tubulointerstitial fibrosis (TIF), thus…”
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Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney by Harley, Geoff, Katerelos, Marina, Gleich, Kurt, Lee, Mardiana, Mount, Peter F, Power, David A

“…The anti-fibrotic effect of metformin has been widely demonstrated. Fibrosis in the kidney after injury is associated with reduced expression of genes involved…”
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Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways by Jha, Jay C, Dai, Aozhi, Garzarella, Jessica, Charlton, Amelia, Urner, Sofia, Østergaard, Jakob A, Okabe, Jun, Holterman, Chet E, Skene, Alison, Power, David A, Ekinci, Elif I, Coughlan, Melinda T, Schmidt, Harald H H W, Cooper, Mark E, Touyz, Rhian M, Kennedy, Chris R, Jandeleit-Dahm, Karin

“…Excessive production of renal reactive oxygen species (ROS) plays a major role in diabetic kidney disease (DKD). Here, we provide key findings demonstrating…”
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Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles by Hu, Chih-Chiang, Katerelos, Marina, Choy, Suet-Wan, Crossthwaite, Amy, Walker, Susan P, Pell, Gabrielle, Lee, Mardiana, Cook, Natasha, Mount, Peter F, Paizis, Kathy, Power, David A

“…Pre-eclampsia is a hypertensive disorder of pregnancy characterised by hypertension and sodium retention by the kidneys. To identify changes in sodium uptake…”
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Balancing the energy equation for healthy kidneys by Mount, Peter F, Power, David A

“…The high‐energy requirement of the kidney and the importance of energy metabolism in renal physiology has been appreciated for decades, but only recently has…”
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Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin by Harley, Geoff, Katerelos, Marina, Gleich, Kurt, de Souza, David P., Narayana, Vinod K., Kemp, Bruce E., Power, David A., Mount, Peter F.

“…Acute kidney injury (AKI) is accompanied by dysregulation of cellular energy metabolism and accumulation of intracellular lipid. Phosphorylation of acetyl-CoA…”
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Role of the energy sensor AMP-activated protein kinase in renal physiology and disease by Hallows, Kenneth R, Mount, Peter F, Pastor-Soler, Núria M, Power, David A

“…The ultrasensitive energy sensor AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and energy-consuming pathways. AMPK is…”
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The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury by Katerelos, Marina, Gleich, Kurt, Harley, Geoff, Loh, Kim, Oakhill, Jonathan S., Kemp, Bruce E., de Souza, David P., Narayana, Vinod K., Coughlan, Melinda T., Laskowski, Adrienne, Ling, Naomi X.Y., Murray-Segal, Lisa, Brink, Robert, Lee, Mardiana, Power, David A., Mount, Peter F.

“…Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK…”
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Three Dimensional Glomerular Reconstruction: A Novel Approach to Evaluate Renal Microanatomy in Diabetic Kidney Disease by Torkamani, Niloufar, Jerums, George, Crammer, Paul, Skene, Alison, Power, David A., Panagiotopoulos, Sianna, Clarke, Michele, MacIsaac, Richard J., Ekinci, Elif I.

“…Mesangial metrics reflect glomerular filtration surface area in diabetes. The point-sampled intercept (PSI) method is the conventional method to calculate…”
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Myocardial Bridging: Diagnosis, Functional Assessment, and Management: JACC State-of-the-Art Review by Sternheim, David, Power, David A, Samtani, Rajeev, Kini, Anapoorna, Fuster, Valentin, Sharma, Samin

“…Myocardial bridging (MB) is a congenital coronary anomaly in which a segment of the epicardial coronary artery traverses through the myocardium for a portion…”
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Vision-Threatening Retinal Abnormalities in Chronic Kidney Disease Stages 3 to 5 by Deva, Rajeev, Alias, Mohamad Afzal, Colville, Deb, Tow, Foong Kien Newk-Fon Hey, Ooi, Qi Lun, Chew, Sky, Mohamad, Nor, Hutchinson, Anastasia, Koukouras, Ignatios, Power, David A, Savige, Judith

“…Retinal abnormalities are common in inherited and acquired renal disease. This study determined the prevalence of retinal abnormalities in chronic kidney…”
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Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK) by Fraser, Scott A, Gimenez, Ignacio, Cook, Natasha, Jennings, Ian, Katerelos, Marina, Katsis, Frosa, Levidiotis, Vicki, Kemp, Bruce E, Power, David A

“…The renal-specific NKCC2 (Na+-K+-2Cl- co-transporter 2) is regulated by changes in phosphorylation state, however, the phosphorylation sites and kinases…”
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Is Nonalbuminuric Renal Insufficiency in Type 2 Diabetes Related to an Increase in Intrarenal Vascular Disease? by MacIsaac, Richard J, Panagiotopoulos, Sianna, McNeil, Karen J, Smith, Trudy J, Tsalamandris, Con, Hao, Huming, Matthews, P. Geoffrey, Thomas, Merlin C, Power, David A, Jerums, George

“…OBJECTIVE:--To investigate the role of intrarenal vascular disease in the pathogenesis of nonalbuminuric renal insufficiency in type 2 diabetes. RESEARCH…”
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Malignant Hypertension Causing a Pulmonary-Renal Syndrome by Yong, Bryan, Power, David A.

“…Background. Pulmonary-renal syndrome is characterised by acute kidney injury, haematuria, and haemoptysis and is a well-recognised presentation of diseases…”
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Implementation of renal key performance indicators: Promoting improved clinical practice by Toussaint, Nigel D, McMahon, Lawrence P, Dowling, Gregory, Soding, Jenny, Safe, Maria, Knight, Richard, Fair, Kathleen, Linehan, Leanne, Walker, Rowan G, Power, David A

“…Aim In the Australian state of Victoria, the Renal Health Clinical Network (RHCN) of the Department of Health Victoria established a Renal Key Performance…”
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The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice by Mount, Peter F, Gleich, Kurt, Tam, Shanna, Fraser, Scott A, Choy, Suet-Wan, Dwyer, Karen M, Lu, Bo, Denderen, Bryce Van, Fingerle-Rowson, Günter, Bucala, Richard, Kemp, Bruce E, Power, David A

“…Activation of the master energy-regulator AMP-activated protein kinase (AMPK) in the heart reduces the severity of ischemia-reperfusion injury (IRI) but the…”
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Understanding Donor-derived Cell-free DNA in Kidney Transplantation: An Overview and Case-based Guide for Clinicians by Graver, Alison S., Lee, Darren, Power, David A., Whitlam, John B.

“…Kidney transplant recipients undergo lifelong monitoring of allograft function and evaluation for transplant complications. The current monitoring paradigm…”
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PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages by Schilperoort, Maaike, Ngai, David, Katerelos, Marina, Power, David A., Tabas, Ira

“…Resolving-type macrophages prevent chronic inflammation by clearing apoptotic cells through efferocytosis. These macrophages are thought to rely mainly on…”
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Noninvasive Imaging of Vulnerable Plaque: One More Piece of the Puzzle by Stone, Gregg W., Power, David A.

“…[Display omitted]…”
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