Search Results - "POWELL, D"

A dynamically cold disk galaxy in the early Universe by Rizzo, F., Vegetti, S., Powell, D., Fraternali, F., McKean, J. P., Stacey, H. R., White, S. D. M.

“…The extreme astrophysical processes and conditions that characterize the early Universe are expected to result in young galaxies that are dynamically different…”
Get full text

Flow resistance in gravel-bed rivers: Progress in research by Powell, D. Mark

“…Resistance to flow determines several important hydraulic parameters in streams and rivers and must be properly represented in models for estimating water…”
Get full text

Targeting metabolism to regulate immune responses in autoimmunity and cancer by Patel, Chirag H., Leone, Robert D., Horton, Maureen R., Powell, Jonathan D.

“…Metabolic programming is emerging as a critical mechanism to alter immune cell activation, differentiation and function. Targeting metabolism does not…”
Get full text

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity by Lynn, R C, Feng, Y, Schutsky, K, Poussin, M, Kalota, A, Dimitrov, D S, Powell Jr, D J

“…Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR)…”
Get full text

Regulation of Immune Responses by mTOR by Powell, Jonathan D, Pollizzi, Kristen N, Heikamp, Emily B, Horton, Maureen R

“…mTOR is an evolutionarily conserved serine threonine kinase that plays a central role in integrating environmental cues in the form of growth factors, amino…”
Get full text

Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior by Wohleb, Eric S, Powell, Nicole D, Godbout, Jonathan P, Sheridan, John F

“…Social stress is associated with altered immunity and higher incidence of anxiety-related disorders. Repeated social defeat (RSD) is a murine stressor that…”
Get full text

Wind and waves in extreme hurricanes by Holthuijsen, Leo H., Powell, Mark D., Pietrzak, Julie D.

“…Waves breaking at the ocean surface are important to the dynamical, chemical and biological processes at the air‐sea interface. The traditional view is that…”
Get full text

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion by Leone, Robert D, Zhao, Liang, Englert, Judson M, Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Arwood, Matthew L, Bettencourt, Ian A, Patel, Chirag H, Wen, Jiayu, Tam, Ada, Blosser, Richard L, Prchalova, Eva, Alt, Jesse, Rais, Rana, Slusher, Barbara S, Powell, Jonathan D

“…The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we…”
Get full text

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism by Powell, Jonathan D., Delgoffe, Greg M.

“…In the two-signal model of T cell activation, the outcome of antigen recognition is determined by the integration of multiple cues in the immune…”
Get full text

Extensive retreat and re-advance of the West Antarctic Ice Sheet during the Holocene by Kingslake, J., Scherer, R. P., Albrecht, T., Coenen, J., Powell, R. D., Reese, R., Stansell, N. D., Tulaczyk, S., Wearing, M. G., Whitehouse, P. L.

“…To predict the future contributions of the Antarctic ice sheets to sea-level rise, numerical models use reconstructions of past ice-sheet retreat after the…”
Get full text

Highly Defective UiO-66 Materials for the Adsorptive Removal of Perfluorooctanesulfonate by Clark, Chelsea A, Heck, Kimberly N, Powell, Camilah D, Wong, Michael S

“…Perfluorooctanesulfonate (PFOS) is a persistent organic pollutant that is bioaccumulative and toxic. While its use in most countries has been restricted to…”
Get full text

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR by Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.

“…Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes…”
Get full text

The Second Victim: a Review by Coughlan, B, Powell, D, Higgins, M.F

“…Abstract Amongst the lay and media population there is a perception that pregnancy, labour and delivery is always physiological, morbidity and mortality should…”
Get full text

The metabolomics workbench file status website: a metadata repository promoting FAIR principles of metabolomics data by Powell, Christian D, Moseley, Hunter N B

“…An updated version of the mwtab Python package for programmatic access to the Metabolomics Workbench (MetabolomicsWB) data repository was released at the…”
Get full text

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis by Powell, Nicole D., Sloan, Erica K., Bailey, Michael T., Arevalo, Jesusa M. G., Miller, Gregory E., Chen, Edith, Kobor, Michael S., Reader, Brenda F., Sheridan, John F., Cole, Steven W.

“…Across a variety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian immune cells have been found to show a…”
Get full text

The marine geological imprint of Antarctic ice shelves by Smith, James A., Graham, Alastair G. C., Post, Alix L., Hillenbrand, Claus-Dieter, Bart, Philip J., Powell, Ross D.

“…Reductions in the thickness and extent of Antarctic ice shelves are triggering increased discharge of marine-terminating glaciers. While the impacts of recent…”
Get full text

Mesenchymal cells of the intestinal lamina propria by Powell, D W, Pinchuk, I V, Saada, J I, Chen, Xin, Mifflin, R C

“…The mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone…”
Get full text

Preventing Allograft Rejection by Targeting Immune Metabolism by Lee, Chen-Fang, Lo, Ying-Chun, Cheng, Chih-Hsien, Furtmüller, Georg J., Oh, Byoungchol, Andrade-Oliveira, Vinicius, Thomas, Ajit G., Bowman, Caitlyn E., Slusher, Barbara S., Wolfgang, Michael J., Brandacher, Gerald, Powell, Jonathan D.

“…Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This…”
Get full text

Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4 + T Helper Cell Differentiation by Powell, Michael D, Read, Kaitlin A, Sreekumar, Bharath K, Oestreich, Kenneth J

“…CD4 T helper cells are capable of differentiating into a number of effector subsets that perform diverse functions during adaptive immune responses. The…”
Get full text

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial by Zambrowicz, B, Freiman, J, Brown, P M, Frazier, K S, Turnage, A, Bronner, J, Ruff, D, Shadoan, M, Banks, P, Mseeh, F, Rawlins, D B, Goodwin, N C, Mabon, R, Harrison, B A, Wilson, A, Sands, A, Powell, D R

“…Thirty‐six patients with type 2 diabetes mellitus (T2DM) were randomized 1:1:1 to receive a once‐daily oral dose of placebo or 150 or 300 mg of the dual…”
Get full text