Search Results - "POWE, Desmond G"

Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer by MAHMOUD, Sahar M. A, CLAIRE PAISH, Emma, POWE, Desmond G, MACMILLAN, R. Douglas, GRAINGE, Matthew J, LEE, Andrew H. S, ELLIS, Ian O, GREEN, Andrew R

“…Breast carcinomas are often infiltrated by inflammatory cells, particularly macrophages and T lymphocytes, but the significance of these cells remains unclear…”
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Local allergic rhinitis: Concept, pathophysiology, and management by Rondón, Carmen, MD, PhD, Campo, Paloma, MD, PhD, Togias, Alkis, MD, PhD, Fokkens, Wytske J., MD, PhD, Durham, Stephen R., MD, PhD, Powe, Desmond G., PhD, Mullol, Joaquim, MD, PhD, Blanca, Miguel, MD, PhD

“…Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy characterized by local production of specific IgE (sIgE)…”
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Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival by Powe, Desmond G, Voss, Melanie J, Zänker, Kurt S, Habashy, Hany O, Green, Andrew R, Ellis, Ian O, Entschladen, Frank

“…Laboratory models show that the beta-blocker, propranolol, can inhibit norepinephrine-induced breast cancer cell migration. We hypothesised that breast cancer…”
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Triple-Negative Breast Cancer: Distinguishing between Basal and Nonbasal Subtypes by RAKHA, Emad A, ELSHEIKH, Somaia E, EVANS, Andy J, BLAMEY, Roger, REIS-FILHO, Jorge S, FOULKES, William D, ELLIS, Ian O, ALESKANDARANY, Muhammed A, HABASHI, Hany O, GREEN, Andrew R, POWE, Desmond G, EL-SAYED, Maysa E, BENHASOUNA, Ahmed, BRUNET, Jean-Sébastien, AKSLEN, Lars A

“…Purpose: Triple-negative (TN; estrogen receptor, progesterone receptor, and HER-2 negative) cancer and basal-like breast cancer (BLBC) are associated with poor…”
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An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer by Mahmoud, Sahar M. A., Paish, Emma C., Powe, Desmond G., Macmillan, R. Douglas, Lee, Andrew H. S., Ellis, Ian O., Green, Andrew R.

“…Studies in mice have shown that thymic-derived CD4+ CD25+ regulatory T cells (T reg; FOXP3 + lymphocytes) inhibit an antitumour immune response. Additional…”
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Biologic and Clinical Characteristics of Breast Cancer With Single Hormone Receptor–Positive Phenotype by RAKHA, Emad A, EL-SAYED, Maysa E, GREEN, Andrew R, PAISH, E. Claire, POWE, Desmond G, GEE, Julia, NICHOLSON, Robert I, LEE, Andrew H. S, ROBERTSON, John F. R, ELLIS, Ian O

“…Response to endocrine therapy in breast cancer correlates with estrogen receptor (ER) and progesterone receptor (PgR) status. It is usually easier to decide…”
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KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer–a targeted molecular approach by Green, William JF, Ball, Graham, Hulman, Geoffrey, Johnson, Catherine, Van Schalwyk, Gerry, Ratan, Hari L, Soria, Daniel, Garibaldi, Jonathan M, Parkinson, Richard, Hulman, Joshua, Rees, Robert, Powe, Desmond G

“…Background: There remains a need to identify and validate biomarkers for predicting prostate cancer (CaP) outcomes using robust and routinely available…”
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Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen by Habashy, Hany Onsy, Powe, Desmond G, Staka, Cindy M, Rakha, Emad A, Ball, Graham, Green, Andrew R, Aleskandarany, Mohammed, Paish, E. Claire, Douglas Macmillan, R, Nicholson, Robert I, Ellis, Ian O, Gee, Julia M. W

“…Transferrin receptor (CD71) is involved in the cellular uptake of iron and is expressed on cells with high proliferation. It may be implicated in promoting the…”
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Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics by Kulkarni, Bina B, Tighe, Patrick J, Mohammed, Imran, Yeung, Aaron M, Powe, Desmond G, Hopkinson, Andrew, Shanmuganathan, Vijay A, Dua, Harminder S

“…The Limbal epithelial crypt (LEC) is a solid cord of cells, approximately 120 microns long. It arises from the undersurface of interpalisade rete ridges of the…”
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Invasive lobular carcinoma of the breast: Response to hormonal therapy and outcomes by Rakha, Emad A, El-Sayed, Maysa E, Powe, Desmond G, Green, Andrew R, Habashy, Hany, Grainge, Matthew J, Robertson, John F.R, Blamey, Roger, Gee, Julia, Nicholson, Robert I, Lee, Andrew H.S, Ellis, Ian O

“…Abstract Invasive lobular carcinoma (ILC) comprises approximately 5–15% of breast cancers and appears to have a distinct biology. It is less common than…”
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Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis by Powe, Desmond G., PhD, Groot Kormelink, Tom, MSc, Sisson, Melanie, BSc, Blokhuis, Bart J., BSc, Kramer, Matthias F., MD, Jones, Nicholas S., MD, Redegeld, Frank A., PhD

“…Background Allergic rhinitis is characterized by mast cell degranulation induced by antigen cross-linking of IgE. It has been proposed that some patients with…”
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Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance by Habashy, Hany Onsy, Powe, Desmond G, Rakha, Emad A, Ball, Graham, Paish, Claire, Gee, Julia, Nicholson, Robert I, Ellis, Ian O

“…Abstract The forkhead-box A1 (FOXA1) controls downstream transcription of oestrogen receptor (ER)-regulated genes. In this study, the biological and prognostic…”
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Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer by Aleskandarany, Mohammed A., Rakha, Emad A., Ahmed, Mohamed A., Powe, Desmond G., Ellis, Ian O., Green, Andrew R.

“…Akt/PKB serine/threonine kinase is a leading signalling modulator for several cellular processes including metabolism, growth, proliferation and survival…”
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DACH1: its role as a classifier of long term good prognosis in luminal breast cancer by Powe, Desmond G, Dhondalay, Gopal Krishna R, Lemetre, Christophe, Allen, Tony, Habashy, Hany O, Ellis, Ian O, Rees, Robert, Ball, Graham R

“…Oestrogen receptor (ER) positive (luminal) tumours account for the largest proportion of females with breast cancer. Theirs is a heterogeneous disease…”
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β2-Adrenergic Signalling Promotes Cell Migration by Upregulating Expression of the Metastasis-Associated Molecule LYPD3 by Gruet, Michael, Cotton, Daniel, Coveney, Clare, Boocock, David J, Wagner, Sarah, Komorowski, Lucie, Rees, Robert C, Pockley, A Graham, Garner, A Christopher, Wallis, John D, Miles, Amanda K, Powe, Desmond G

“…Metastasis is associated with poor prognosis in breast cancer. Although some studies suggest beta-blockers increase survival by delaying metastasis, others…”
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Norepinephrine inhibits the migratory activity of pancreatic cancer cells by Stock, Anna-Maria, Powe, Desmond G., Hahn, Stephan A., Troost, Gabriele, Niggemann, Bernd, Zänker, Kurt S., Entschladen, Frank

“…We have shown previously that norepinephrine induces migratory activity of tumour cells from breast, colon and prostate tissue via activation of beta-2…”
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Heterotrimeric G protein signaling in cancer cells with regard to metastasis formation by Entschladen, Frank, Zänker, Kurt S., Powe, Desmond G.

“…The signal transduction mediated by heterotrimeric G proteins is involved in the regulation of a plethora of cell functions ranging from the sensation of…”
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Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism by Voss, Melanie J, Möller, Mischa F, Powe, Desmond G, Niggemann, Bernd, Zänker, Kurt S, Entschladen, Frank

“…Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on…”
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EpCAM expression is an indicator of recurrence in basal-like breast cancer by Agboola, Ayodeji J., Paish, E. Claire, Rakha, Emad A., Powe, Desmond G., Macmillan, R. Douglas, Ellis, Ian O., Green, Andrew R.

“…Advances in the understanding of the molecular basis of breast cancer have necessitated a definition of more sensitive and specific indicators of prognosis…”
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Growth fraction as a predictor of response to chemotherapy in node‐negative breast cancer by Aleskandarany, Mohammed A., Green, Andrew R., Rakha, Emad A., Mohammed, Rabab A., Elsheikh, Somaia E., Powe, Desmond G., Paish, Emma C., Macmillan, R. Douglas, Chan, Steve, Ahmed, Samreen I., Ellis, Ian O.

“…Accurate predictive markers of chemotherapeutic response in early breast cancer are still lacking. The role of tumour growth fraction as a predictor of…”
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