Search Results - "POURAT, Jacob"

Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer by Sharma, Sai Kiran, Pourat, Jacob, Abdel-Atti, Dalya, Carlin, Sean D, Piersigilli, Alessandra, Bankovich, Alexander J, Gardner, Eric E, Hamdy, Omar, Isse, Kumiko, Bheddah, Sheila, Sandoval, Joseph, Cunanan, Kristen M, Johansen, Eric B, Allaj, Viola, Sisodiya, Vikram, Liu, David, Zeglis, Brian M, Rudin, Charles M, Dylla, Scott J, Poirier, John T, Lewis, Jason S

“…The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell lung cancer (SCLC) and high-grade neuroendocrine carcinomas…”
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Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy by Pereira, Patrícia M. R., Sharma, Sai Kiran, Carter, Lukas M., Edwards, Kimberly J., Pourat, Jacob, Ragupathi, Ashwin, Janjigian, Yelena Y., Durack, Jeremy C., Lewis, Jason S.

“…Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein overexpression in tumors is a prerequisite for initiation of trastuzumab…”
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Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models by Sharma, Sai Kiran, Chow, Andrew, Monette, Sebastien, Vivier, Delphine, Pourat, Jacob, Edwards, Kimberly J, Dilling, Thomas R, Abdel-Atti, Dalya, Zeglis, Brian M, Poirier, John T, Lewis, Jason S

“…A critical benchmark in the development of antibody-based therapeutics is demonstration of efficacy in preclinical mouse models of human disease, many of which…”
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Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models by Keinänen, Outi, Fung, Kimberly, Pourat, Jacob, Jallinoja, Vilma, Vivier, Delphine, Pillarsetty, NagaVara Kishore, Airaksinen, Anu J., Lewis, Jason S., Zeglis, Brian M., Sarparanta, Mirkka

“…Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the…”
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ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody by Sharma, Sai Kiran, Mack, Kyeara N, Piersigilli, Alessandra, Pourat, Jacob, Edwards, Kimberly J, Keinänen, Outi, Jiao, Maria S, Zhao, Huiyong, White, Brandy, Brooks, Cory L, de Stanchina, Elisa, Madiyalakan, Madi R, Hollingsworth, Michael A, Radhakrishnan, Prakash, Lewis, Jason S, Zeglis, Brian M

“…Advances in our understanding of the contribution of aberrant glycosylation to the pro-oncogenic signaling and metastasis of tumor cells have reinvigorated the…”
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Multimodality labeling strategies for the investigation of nanocrystalline cellulose biodistribution in a mouse model of breast cancer by Sarparanta, Mirkka, Pourat, Jacob, Carnazza, Kathryn E., Tang, Jun, Paknejad, Navid, Reiner, Thomas, Kostiainen, Mauri A., Lewis, Jason S.

“…We have developed a nuclear and fluorescence labeling strategy for nanocrystalline cellulose (CNC), an emerging biomaterial with versatile chemistry and facile…”
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PET Imaging of Extracellular pH in Tumors with (64)Cu- and (18)F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study by Demoin, Dustin Wayne, Wyatt, Linden C, Edwards, Kimberly J, Abdel-Atti, Dalya, Sarparanta, Mirkka, Pourat, Jacob, Longo, Valerie A, Carlin, Sean D, Engelman, Donald M, Andreev, Oleg A, Reshetnyak, Yana K, Viola-Villegas, Nerissa, Lewis, Jason S

“…pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants…”
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Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET by Sharma, Sai Kiran, Adumeau, Pierre, Keinänen, Outi, Sisodiya, Vikram, Sarvaiya, Hetal, Tchelepi, Robert, Korsen, Joshua A, Pourat, Jacob, Edwards, Kimberly J, Ragupathi, Ashwin, Hamdy, Omar, Saunders, Laura R, Rudin, Charles M, Poirier, John T, Lewis, Jason S, Zeglis, Brian M

“…Delta-like ligand 3 (DLL3) is a therapeutic target for the treatment of small cell lung cancer, neuroendocrine prostate cancer, and isocitrate dehydrogenase…”
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Abstract 4205: Targeting a variety of cancers with NOTA-derivatized pH (low) insertion peptide (pHLIP) complexes with 64Cu and 18F: What cancers are targetable by Demoin, Dustin W., Edwards, Kimberly J., Wyatt, Linden C., Sarparanta, Mirkka, Pourat, Jacob, Andreev, Oleg A., Reshetnyak, Yana K., Viola-Villegas, Nerissa, Lewis, Jason S.

“…Introduction: Although heterogeneous, the extracellular tumor environment is generally marked by decreased pH relative to nontumor tissues due to cancer cell…”
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RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis by KAZEROUNIAN, Shiva, GERALD, Damien, PHUNG, Thuy L, BRAVO-NUEVO, Arturo, SHECHTER, Sharon, MCNAMARA, Stephanie, DUHADAWAY, James B, KOCHER, Olivier N, BROWN, Lawrence F, TOKER, Alex, PRENDERGAST, George C, BENJAMIN, Laura E, MINZHOU HUANG, REBECCA CHIN, Y, UDAYAKUMAR, Durga, NINGNING ZHENG, O'DONNELL, Rebekah K, PERRUZZI, Carole, MANGIANTE, Lee, POURAT, Jacob

“…Tumors are composed of cancer cells but also a larger number of diverse stromal cells in the tumor microenvironment. Stromal cells provide essential supports…”
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PET Imaging of Extracellular pH in Tumors with 64 Cu- and 18 F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study by Demoin, Dustin Wayne, Wyatt, Linden C., Edwards, Kimberly J., Abdel-Atti, Dalya, Sarparanta, Mirkka, Pourat, Jacob, Longo, Valerie A., Carlin, Sean D., Engelman, Donald M., Andreev, Oleg A., Reshetnyak, Yana K., Viola-Villegas, Nerissa, Lewis, Jason S.

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PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F‑Labeled pHLIP Peptides: A Structure–Activity Optimization Study by Demoin, Dustin Wayne, Wyatt, Linden C., Edwards, Kimberly J., Abdel-Atti, Dalya, Sarparanta, Mirkka, Pourat, Jacob, Longo, Valerie A., Carlin, Sean D., Engelman, Donald M., Andreev, Oleg A., Reshetnyak, Yana K., Viola-Villegas, Nerissa, Lewis, Jason S.

“…pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants…”
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PET Imaging of Extracellular pH in Tumors with ^sup 64^Cu- and ^sup 18^F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study by Demoin, Dustin Wayne, Wyatt, Linden C, Edwards, Kimberly J, Abdel-Atti, Dalya, Sarparanta, Mirkka, Pourat, Jacob, Longo, Valerie A, Carlin, Sean D, Engelman, Donald M, Andreev, Oleg A, Reshetnyak, Yana K, Viola-Villegas, Nerissa, Lewis, Jason S

“…pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants…”
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PET Imaging of Extracellular pH in Tumors with super( 64)Cu- and super( 18)F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study by Demoin, Dustin Wayne, Wyatt, Linden C, Edwards, Kimberly J, Abdel-Atti, Dalya, Sarparanta, Mirkka, Pourat, Jacob, Longo, Valerie A, Carlin, Sean D, Engelman, Donald M, Andreev, Oleg A, Reshetnyak, Yana K, Viola-Villegas, Nerissa, Lewis, Jason S

“…pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants…”
Get full text

Non-invasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer by Sharma, Sai Kiran, Pourat, Jacob, Abdel-Atti, Dalya, Carlin, Sean D., Piersigilli, Alessandra, Bankovich, Alexander J., Gardner, Eric E., Hamdy, Omar, Isse, Kumiko, Bheddah, Sheila, Sandoval, Joseph, Cunanan, Kristen M., Johansen, Eric B., Allaj, Viola, Sisodiya, Vikram, Liu, David, Zeglis, Brian M., Rudin, Charles M., Dylla, Scott J., Poirier, John T., Lewis, Jason S.

“…The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell lung cancer (SCLC) and high-grade neuroendocrine carcinomas…”
Get full text

Pretargeting of internalizing trastuzumab and cetuximab with a 18 F-tetrazine tracer in xenograft models by Keinänen, Outi, Fung, Kimberly, Pourat, Jacob, Jallinoja, Vilma, Vivier, Delphine, Pillarsetty, NagaVara Kishore, Airaksinen, Anu J, Lewis, Jason S, Zeglis, Brian M, Sarparanta, Mirkka

“…Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient…”
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Growth inhibition of colon cancer cells by compounds affecting AMPK activity by Lea, Michael A, Pourat, Jacob, Patel, Rupali, desBordes, Charles

“…To determine if other molecules reported to modulate AMP-dependent protein kinase (AMPK) activity would have effects resembling those of metformin and…”
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