Search Results - "POUNDS, J. G"

Preparation and characterization challenges to understanding environmental and biological impacts of ceria nanoparticles by Karakoti, A. S., Munusamy, P., Hostetler, K., Kodali, V., Kuchibhatla, S., Orr, G., Pounds, J. G., Teeguarden, J. G., Thrall, B. D., Baer, D. R.

“…Increasingly, it is recognized that understanding and predicting nanoparticle behavior are often limited by the reliability and reproducibility of the…”
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Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis, and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment, and cell cycle phase by McCabe, Jr, M J, Singh, K P, Reddy, S A, Chelladurai, B, Pounds, J G, Reiners, Jr, J J, States, J C

“…Arsenite treatment has been found to induce clinical remission in patients with acute promyelocytic leukemia. Although the potential therapeutic value of…”
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The ICRP Age-Specific Biokinetic Model for Lead: Validations, Empirical Comparisons, and Explorations by Pounds, Joel G., Leggett, Richard W.

“…The objective of this manuscript is to provide a description of the International Commission for Radiation Protection (ICRP) model and a comparison to other…”
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A Nonlinear Isobologram Model with Box-Cox Transformation to Both Sides for Chemical Mixtures by Ding G. Chen, Pounds, Joel G.

“…The linear logistical isobologram is a commonly used and powerful graphical and statistical tool for analyzing the combined effects of simple chemical…”
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Problems in determination of skeletal lead burden in archaeological samples: An example from the First African Baptist Church population by Wittmers Jr, L.E., Aufderheide, A.C., Pounds, J.G., Jones, K.W., Angel, J.L.

“…Human bone lead content has been demonstrated to be related to socioeconomic status, occupation and other social and environmental correlates. Skeletal tissue…”
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Effect of lead intoxication on calcium homeostasis and calcium-mediated cell function: a review by Pounds, J G

“…The interaction between lead and essential metals is a complex, well recognized, but poorly understood phenomenon. Dietary deficiencies or excesses of certain…”
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Distribution of Trace Levels of Therapeutic Gallium in Bone as Mapped by Synchrotron X-Ray Microscopy by Bockman, R. S., Repo, M. A., Warrell, R. P., Pounds, J. G., Schidlovsky, G., Gordon, B. M., Jones, K. W.

“…Gallium nitrate, a drug that inhibits calcium release from bone, has been proven a safe and effective treatment for the accelerated bone resorption associated…”
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Lead inhibits meso-2,3-dimercaptosuccinic acid induced calcium transients in cultured rhesus monkey kidney cells by Pokorski, Philip L., McCabe, Michael J., Pounds, Joel G.

“…Previously we have shown that meso-2,3-dimercaptosuccinic acid (DMSA, 15–500 μM) elicits concentration-dependent increases in intracellular calcium levels ([Ca…”
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Lead impairs the production of osteocalcin by rat osteosarcoma (ROS 17/2.8) cells by Long, G J, Rosen, J F, Pounds, J G

“…The serum level of osteocalcin, a bone-specific protein produced by osteoblasts and an index of bone formation, is decreased in lead-intoxicated children. To…”
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meso-2,3-Dimercaptosuccinic acid induces calcium transients in cultured rhesus monkey kidney cells by Pokorski, Philip L, McCabe, Michael J, Pounds, Joel G

“…The maintenance of intracellular Ca 2+ homeostasis is critical to many cellular functions that rely on the calcium ion as a messenger. While attempting to…”
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Cellular and Molecular Toxicity of Lead in Bone by Pounds, Joel G., Long, Gregory J., Rosen, John F.

“…To fully understand the significance of bone as a target tissue of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the…”
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Chemical mixtures from a public health perspective: the importance of research for informed decision making by Sexton, Ken, Beck, Barbara D., Bingham, Eula, Brain, Joseph D., DeMarini, David M., Hertzberg, Richard C., O'Flaherty, Ellen J., Pounds, Joel G.

“…When considered from a public health perspective, the central question regarding chemical mixtures is deceptively simple: Are current approaches to risk…”
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New dimensions of lead neurotoxicity: redefining mechanisms and effects by Pounds, J G, Cory-Slechta, D A

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Lead intoxication alters basal and parathyroid hormone-regulated cellular calcium homeostasis in rat osteosarcoma (ROS 17/2.8) cells by LONG, G. J, POUNDS, J. G, ROSEN, J. F

“…The skeleton is the major reservoir of lead and calcium in humans, and plays an important role in systemic calcium regulation. Lead perturbs normal calcium…”
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Cellular lead toxicity and metabolism in primary and clonal osteoblastic bone cells by Long, G J, Rosen, J F, Pounds, J G

“…A knowledge of bone lead metabolism is critical for understanding the toxicological importance of bone lead, as a toxicant both to bone cells and to soft…”
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Estimation of cumulative lead releases (lead flux) from the maternal skeleton during pregnancy and lactation by Gulson, B.L, Pounds, J.G, Mushak, P, Thomas, B.J, Gray, B, Korsch, M.J

“…Recent longitudinal studies with human subjects and nonhuman primates using high-precision stable lead isotopes show that lead is mobilized from the maternal…”
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Arsenite Disrupts Mitosis and Induces Apoptosis in SV40-Transformed Human Skin Fibroblasts by States, J.Christopher, Reiners, John J., Pounds, Joel G., Kaplan, David J., Beauerle, Brian D., McNeely, Samuel C., Mathieu, Patricia, McCabe, Michael J.

“…Chronic ingestion of arsenite-contaminated drinking water causes skin, bladder, and liver cancer. The mechanism of arsenite-induced carcinogenesis is unknown…”
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Cocaine toxicity in cultured rat hepatocytes by Roberts, S M, Pounds, J G, James, R C

“…Cocaine hydrochloride was added to primary cultures of hepatocytes isolated from naive and phenobarbital-induced (80 mg/kg i.p. for 3 d) Sprague-Dawley rats…”
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Cellular metabolism of lead: a kinetic analysis in cultured osteoclastic bone cells by Pounds, J G, Rosen, J F

“…Detailed characterization of the modulation of lead metabolism in bone is necessary to understand the role of skeletal lead in the expression of clinical and…”
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Interactive toxicity of simple chemical mixtures of cadmium, mercury, methylmercury and trimethyltin: model-dependent responses by Pounds, Joel G., Haider, Jamal, Chen, D.G., Mumtaz, Moiz

“…Scientific and societal interest in the analysis of aggregate toxicity derives from the fact that people are seldom exposed to single chemicals, but rather to…”
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