Search Results - "POULSEN, Henrik E"

Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid by Poulsen, Henrik E., Nadal, Laia Llovera, Broedbaek, Kasper, Nielsen, Peter E., Weimann, Allan

“…DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied…”
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Specific prediction of mortality by oxidative stress‐induced damage to RNA vs. DNA in humans by Jorgensen, Anders, Brandslund, Ivan, Ellervik, Christina, Henriksen, Trine, Weimann, Allan, Andersen, Per Kragh, Poulsen, Henrik E.

“…Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age‐associated medical disorders…”
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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise by Klein, Anders B., Nicolaisen, Trine S., Ørtenblad, Niels, Gejl, Kasper D., Jensen, Rasmus, Fritzen, Andreas M., Larsen, Emil L., Karstoft, Kristian, Poulsen, Henrik E., Morville, Thomas, Sahl, Ronni E., Helge, Jørn W., Lund, Jens, Falk, Sarah, Lyngbæk, Mark, Ellingsgaard, Helga, Pedersen, Bente K., Lu, Wei, Finan, Brian, Jørgensen, Sebastian B., Seeley, Randy J., Kleinert, Maximilian, Kiens, Bente, Richter, Erik A., Clemmensen, Christoffer

“…Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like…”
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RNA modifications by oxidation: A novel disease mechanism? by Poulsen, Henrik E., Specht, Elisabeth, Broedbaek, Kasper, Henriksen, Trine, Ellervik, Christina, Mandrup-Poulsen, Thomas, Tonnesen, Morten, Nielsen, Peter E., Andersen, Henrik U., Weimann, Allan

“…The past decade has provided exciting insights into a novel class of central (small) RNA molecules intimately involved in gene regulation. Only a small…”
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Statin treatment, oxidative stress and inflammation in a Danish population by Sørensen, Anders L, Hasselbalch, Hans C, Nielsen, Claus H, Poulsen, Henrik E, Ellervik, Christina

“…While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences…”
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Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression by Jorgensen, Anders, Köhler-Forsberg, Kristin, Henriksen, Trine, Weimann, Allan, Brandslund, Ivan, Ellervik, Christina, Poulsen, Henrik E., Knudsen, Gitte Moos, Frokjaer, Vibe G., Jorgensen, Martin B.

“…Previous studies have indicated that antidepressants that inhibit the serotonin transporter reduces oxidative stress. DNA and RNA damage from oxidation is…”
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Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial by Franzke, Bernhard, Schober-Halper, Barbara, Hofmann, Marlene, Oesen, Stefan, Tosevska, Anela, Henriksen, Trine, Poulsen, Henrik E., Strasser, Eva-Maria, Wessner, Barbara, Wagner, Karl-Heinz

“…The purpose of this study was to investigated the effect of age – over or under life-expectancy (LE) – on six months resistance training alone or combined with…”
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Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans by Joergensen, Anders, Broedbaek, Kasper, Weimann, Allan, Semba, Richard D, Ferrucci, Luigi, Joergensen, Martin B, Poulsen, Henrik E

“…Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress…”
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Systemic oxidatively generated DNA/RNA damage in clinical depression: Associations to symptom severity and response to electroconvulsive therapy by Jorgensen, Anders, Krogh, Jesper, Miskowiak, Kamilla, Bolwig, Tom G, Kessing, Lars V, Fink-Jensen, Anders, Nordentoft, Merete, Henriksen, Trine, Weimann, Allan, Poulsen, Henrik E, Jorgensen, Martin B

“…Abstract Background Depression has been associated with increased oxidative stress and hypothesized to accelerate aging. Nucleic acid damage from oxidation is…”
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Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2′-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry by Henriksen, Trine, Hillestrøm, Peter R., Poulsen, Henrik E., Weimann, Allan

“…The potential use of oxidative stress-induced DNA and RNA damage products as biomarkers is an important aspect of biomedical research. There is a need for…”
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Urinary Markers of Nucleic Acid Oxidation and Long-Term Mortality of Newly Diagnosed Type 2 Diabetic Patients by Broedbaek, Kasper, Siersma, Volkert, Henriksen, Trine, Weimann, Allan, Petersen, Morten, Andersen, Jon T, Jimenez-Solem, Espen, Stovgaard, Elisabeth S, Hansen, Lars J, Henriksen, Jan Erik, Bonnema, Steen J, de Fine Olivarius, Niels, Poulsen, Henrik E

“…OBJECTIVE: We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid…”
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Elimination of Ascorbic Acid After High‐Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation by Nielsen, Torben K., Højgaard, Martin, Andersen, Jon T., Poulsen, Henrik E., Lykkesfeldt, Jens, Mikines, Kári J.

“…Treatment with high‐dose intravenous (IV) ascorbic acid (AA) is used in complementary and alternative medicine for various conditions including cancer…”
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Mice do not habituate to metabolism cage housing--a three week study of male BALB/c mice by Kalliokoski, Otto, Jacobsen, Kirsten R, Darusman, Huda S, Henriksen, Trine, Weimann, Allan, Poulsen, Henrik E, Hau, Jann, Abelson, Klas S P

“…The metabolism cage is a barren, non-enriched, environment, combining a number of recognized environmental stressors. We investigated the ability of male…”
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Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study by Sørensen, Anders L., Hasselbalch, Hans C., Bjørn, Mads Emil, Nielsen, Claus H., Cordua, Sabrina, Skov, Vibe, Kjær, Lasse, Poulsen, Henrik E., Ellervik, Christina

“…It is unknown if the somatic mutations in chronic myeloproliferative neoplasms (MPNs), JAK2V617F and Calreticulin, are associated with oxidative stress, or…”
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Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? by Collins, Andrew R, Cadet, Jean, Mőller, Lennart, Poulsen, Henrik E, Viña, Jose

“…The most commonly measured marker of oxidative DNA damage is 8-oxo-7,8-dihydroguanine (8-oxoGua) or its deoxyribonucleoside (8-oxodGuo). Published estimates of…”
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Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis by Broedbaek, Kasper, Poulsen, Henrik E., Weimann, Allan, Kom, Ghainsom D., Schwedhelm, Edzard, Nielsen, Peter, Böger, Rainer H.

“…Oxidatively generated damage to nucleic acids is considered to play a significant role in carcinogenesis, and it has been shown that people with hereditary…”
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The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the "DOSE-EX" multi-arm parallel-group randomised clinical trial by Lyngbaek, Mark P P, Legaard, Grit E, Bennetsen, Sebastian L, Feineis, Camilla S, Rasmussen, Villads, Moegelberg, Nana, Brinkløv, Cecilie F, Nielsen, Anette B, Kofoed, Katja S, Lauridsen, Carsten A, Ewertsen, Caroline, Poulsen, Henrik E, Christensen, Robin, Van Hall, Gerrit, Karstoft, Kristian, Solomon, Thomas P J, Ellingsgaard, Helga, Almdal, Thomas P, Pedersen, Bente K, Ried-Larsen, Mathias

“…Lifestyle intervention, i.e. diet and physical activity, forms the basis for care of type 2 diabetes (T2D). The current physical activity recommendation for…”
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Hypothyroid women have persistently higher oxidative stress compared to healthy controls by Riis, Kamilla Ryom, Larsen, Camilla, Medici, Bjarke Røssner, Jensen, Christian Zinck, Winther, Kristian H, Larsen, Emil List, Ellervik, Christina, la Cour, Jeppe Lerche, Hegedus, Laszlo, Brix, Thomas Heiberg, Poulsen, Henrik Enghusen, Knop, Filip K, Nygaard, Birte, Bonnema, Steen Joop

“…Objective: Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo)…”
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Urinary albumin and 8-oxo-7,8-dihydroguanosine as markers of mortality and cardiovascular disease during 19 years after diagnosis of type 2 diabetes – A comparative study of two markers to identify high risk patients by Broedbaek, Kasper, Køster-Rasmussen, Rasmus, Siersma, Volkert, Persson, Frederik, Poulsen, Henrik E., de Fine Olivarius, Niels

“…Urinary albumin is an important biomarker used to identify high risk patients with diabetes, but there is a need for new biomarkers that alone or in…”
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Effects of 2-Year Nutritional and Lifestyle Intervention on Oxidative and Inflammatory Statuses in Individuals of 55 Years of Age and over at High Cardiovascular Risk by Monserrat-Mesquida, Margalida, Quetglas-Llabrés, Magdalena, Bouzas, Cristina, García, Silvia, Mateos, David, Gómez, Cristina, Gámez, José M., Poulsen, Henrik E., Tur, Josep A., Sureda, Antoni

“…Obesity and overweight are disorders with high impact on the morbidity and mortality of chronic diseases, such as type 2 diabetes mellitus (T2DM) and…”
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