Search Results - "POULOS, T. L"

Redox Control of the Catalytic Cycle of Flavocytochrome P-450 BM3 by Daff, S. N, Chapman, S. K, Holt, R. A, Govindaraj, S, Poulos, T. L, Munro, A. W

“…Flavocytochrome P-450 BM3 from Bacillus megaterium is a 119 kDa polypeptide whose heme and diflavin domains are fused to produce a catalytically…”
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Low-Frequency Dynamics of Caldariomyces fumago Chloroperoxidase Probed by Femtosecond Coherence Spectroscopy by Gruia, Flaviu, Ionascu, Dan, Kubo, Minoru, Ye, Xiong, Dawson, John, Osborne, Robert L, Sligar, S. G, Denisov, Ilia, Das, Aditi, Poulos, T. L, Terner, James, Champion, Paul M

“…Ultrafast laser spectroscopy techniques are used to measure the low-frequency vibrational coherence spectra and nitric oxide rebinding kinetics of…”
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Crystal Structure of Heme Oxygenase from the Gram-Negative Pathogen Neisseria meningitidis and a Comparison with Mammalian Heme Oxygenase-1 by Schuller, David J, Zhu, Wenming, Stojiljkovic, Igor, Wilks, Angela, Poulos, Thomas L

“…We report the crystal structure of heme oxygenase from the pathogenic bacterium Neisseria meningitidis at 1.5 Å and compare and contrast it with known…”
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Crystallographic refinement of lignin peroxidase at 2 A by POULOS, T. L, EDWARDS, S. L, WARIISHI, H, GOLD, M. H

“…The crystal structure of the major lignin peroxidase isozyme from Phanerocheate chrysosporium has been refined to an R = 0.15 for data between 8 A and 2.03 A…”
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The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450 by Poulos, T L, Finzel, B C, Gunsalus, I C, Wagner, G C, Kraut, J

“…The crystal structure of Pseudomonas putida cytochrome P-450cam in the ferric, camphor bound form has been determined and partially refined to R = 0.23 at 2.6…”
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Crystal Structure of Nitric Oxide Synthase Bound to Nitro Indazole Reveals a Novel Inactivation Mechanism by Raman, C. S, Li, Huiying, Martásek, Pavel, Southan, Garry, Masters, Bettie Sue S, Poulos, Thomas L

“…Nitric oxide is generated under normal and pathophysiological conditions by three distinct isoforms of nitric oxide synthase (NOS). A small-molecule inhibitor…”
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Crystal structure of yeast cytochrome c peroxidase refined at 1.7-A resolution by Finzel, B C, Poulos, T L, Kraut, J

“…The crystal structure of cytochrome c peroxidase (EC 1.11.1.5) has been refined to an R factor of 0.20 computed for all reflections to 1.7 A. The refined…”
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Crystal Structure of Nitrosomonas europaea Cytochrome c Peroxidase and the Structural Basis for Ligand Switching in Bacterial Di-heme Peroxidases by Shimizu, Hideaki, Schuller, David J, Lanzilotta, William N, Sundaramoorthy, M, Arciero, David M, Hooper, Alan B, Poulos, Thomas L

“…The crystal structure of the fully oxidized di-heme peroxidase from Nitrosomonas europaea has been solved to a resolution of 1.80 Å and compared to the closely…”
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Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation by Raag, Reetta, Poulos, Thomas L

“…X-ray crystal structures have been determined for complexes of cytochrome P-450CAM with the substrates camphane, adamantane, and thiocamphor. Unlike the…”
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Crystal structure of lignin peroxidase by Edwards, S.L. (National Institutes of Health, Bethesda, MD), Raag, R, Wariishi, H, Gold, M.H, Poulos, T.L

“…The crystal structure of lignin peroxidase (LiP) from the basidiomycete Phanerochaete chrysosporium has been determined to 2.6 angstroms resolution by using…”
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The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation by Webster, S.D, Tenner, A.J, Poulos, T.L, Cribbs, D.H

“…In transgenic models of Alzheimer’s disease (AD) neuronal loss has not been widely observed. The loss of neurons in AD may be due to chronic activation of…”
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Role of the proximal ligand in peroxidase catalysis. Crystallographic, kinetic, and spectral studies of cytochrome c peroxidase proximal ligand mutants by Choudhury, K, Sundaramoorthy, M, Hickman, A, Yonetani, T, Woehl, E, Dunn, M F, Poulos, T L

“…The role of the proximal histidine ligand in peroxidase function was studied by replacing the His side chain in cytochrome c peroxidase with Gln, Glu, or Cys…”
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Cytochrome P450cam: crystallography, oxygen activation, and electron transfer by Poulos, T L, Raag, R

“…Several crystal structures of various substrate and inhibited complexes of the camphor monoxygenase, cytochrome P450cam from Pseudomonas putida, are now…”
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Ligand binding and structural perturbations in cytochrome c peroxidase. A crystallographic study by EDWARDS, S. L, POULOS, T. L

“…Crystal structures of the complexes formed between cytochrome c peroxidase and cyanide, nitric oxide, carbon monoxide, and fluoride have been determined and…”
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High-resolution crystal structure of cytochrome P450cam by Poulos, T L, Finzel, B C, Howard, A J

“…The crystal structure of Pseudomonas putida cytochrome P450cam with its substrate, camphor, bound has been refined to R = 0.19 at a normal resolution of 1.63…”
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Laser Flash Induced Electron Transfer in P450cam Monooxygenase:  Putidaredoxin Reductase−Putidaredoxin Interaction by Sevrioukova, Irina F, Hazzard, James T, Tollin, Gordon, Poulos, Thomas L

“…The P450cam monooxygenase from Pseudomonas putida consists of three redox proteins:  NADH−putidaredoxin reductase (Pdr), putidaredoxin (Pdx), and cytochrome…”
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Crystal Structure of Cytochrome P450 14α-Sterol Demethylase (CYP51) from Mycobacterium tuberculosis in Complex with Azole Inhibitors by Podust, Larissa M., Poulos, Thomas L., Waterman, Michael R.

“…Cytochrome P450 14α-sterol demethylases (CYP51) are essential enzymes in sterol biosynthesis in eukaryotes. CYP51 removes the 14α-methyl group from sterol…”
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A study of the K(+)-site mutant of ascorbate peroxidase: mutations of protein residues on the proximal side of the heme cause changes in iron ligation on the distal side by Cheek, J, Mandelman, D, Poulos, T L, Dawson, J H

“…A series of ferric and ferrous derivatives of wild-type ascorbate peroxidase (APX) and of an engineered K(+)-site mutant of APX that has had its potassium…”
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Characterization and crystallization of recombinant pea cytosolic ascorbate peroxidase by Patterson, W.R, Poulos, T.L

“…An Escherichia coli expression system has been developed for a cytosolic ascorbate peroxidase (APX). The enzyme was expressed as a fusion product with the E…”
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Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex by Raag, Reetta, Poulos, Thomas L

“…The crystal structure of the ternary complex formed between carbon monoxide (CO), camphor, and ferrous cytochrome P-450CAM has been refined to an R value of…”
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