Search Results - "POTT, Lutz"

Pannexin 1 Constitutes the Large Conductance Cation Channel of Cardiac Myocytes by Kienitz, Marie-Cecile, Bender, Kirsten, Dermietzel, Rolf, Pott, Lutz, Zoidl, Georg

“…A large conductance (∼300 picosiemens) channel (LCC) of unknown molecular identity, activated by Ca2+ release from the sarcoplasmic reticulum, particularly…”
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KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting by Wrobel, Eva, Rothenberg, Ina, Krisp, Christoph, Hundt, Franziska, Fraenzel, Benjamin, Eckey, Karina, Linders, Joannes T. M., Gallacher, David J., Towart, Rob, Pott, Lutz, Pusch, Michael, Yang, Tao, Roden, Dan M., Kurata, Harley T., Schulze-Bahr, Eric, Strutz-Seebohm, Nathalie, Wolters, Dirk, Seebohm, Guiscard

“…Most small-molecule inhibitors of voltage-gated ion channels display poor subtype specificity because they bind to highly conserved residues located in the…”
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Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K + Channel) Channel Function by Kuß, Johanna, Stallmeyer, Birgit, Goldstein, Matthias, Rinné, Susanne, Pees, Christiane, Zumhagen, Sven, Seebohm, Guiscard, Decher, Niels, Pott, Lutz, Kienitz, Marie-Cécile, Schulze-Bahr, Eric

“…Inherited forms of sinus node dysfunction (SND) clinically include bradycardia, sinus arrest, and chronotropic incompetence and may serve as disease models to…”
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A genetically encoded tool kit for manipulating and monitoring membrane phosphatidylinositol 4,5-bisphosphate in intact cells by Hertel, Fabian, Switalski, Agathe, Mintert-Jancke, Elisa, Karavassilidou, Katharina, Bender, Kirsten, Pott, Lutz, Kienitz, Marie-Cécile

“…Most ion channels are regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) in the cell membrane by diverse mechanisms. Important molecular…”
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Altered stress stimulation of inward rectifier potassium channels in Andersen‐Tawil syndrome by Seebohm, Guiscard, Strutz‐Seebohm, Nathalie, Ursu, Oana N., Preisig‐Müller, Regina, Zuzarte, Marylou, Hill, Elaine V., Kienitz, Marie‐Cécile, Bendahhou, Said, Fauler, Michael, Tapken, Daniel, Decher, Niels, Collins, Anthony, Jurkat‐Rott, Karin, Steinmeyer, Klaus, Lehmann‐Horn, Frank, Daut, Jürgen, Tavaré, Jeremy M., Pott, Lutz, Bloch, Wilhelm, Lang, Florian

“…ABSTRACT Inward rectifier potassium channels of the Kir2 subfamily are important determinants of the electrical activity of brain and muscle cells. Genetic…”
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Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4 by Mintert, Elisa, Bösche, Leif I., Rinne, Andreas, Timpert, Mathias, Kienitz, Marie‐Cécile, Pott, Lutz, Bender, Kirsten

“…Apart from gating by interaction with βγ subunits from heterotrimeric G proteins upon stimulation of appropriate receptors, Kir.3 channels have been shown to…”
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Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors by Liliom, K, Sun, G, Bünemann, M, Virág, T, Nusser, N, Baker, D L, Wang, D A, Fabian, M J, Brandts, B, Bender, K, Eickel, A, Malik, K U, Miller, D D, Desiderio, D M, Tigyi, G, Pott, L

“…Blood plasma and serum contain factors that activate inwardly rectifying GIRK1/GIRK4 K+ channels in atrial myocytes via one or more non-atropine-sensitive…”
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Depletion of Phosphatidylinositol 4,5-Bisphosphate by Activation of Phospholipase C-coupled Receptors Causes Slow Inhibition but Not Desensitization of G Protein-gated Inward Rectifier K+ Current in Atrial Myocytes by Meyer, Thomas, Wellner-Kienitz, Marie-Cécile, Biewald, Anke, Bender, Kirsten, Eickel, Andreas, Pott, Lutz

“…G protein-gated inwardly rectifier K+ current in atrial myocytes (IK(ACh)) upon stimulation with acetylcholine (ACh) shows a fast desensitizing component (t1/2…”
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Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate by van Koppen, C, Meyer zu Heringdorf, M, Laser, K T, Zhang, C, Jakobs, K H, Bünemann, M, Pott, L

“…Sphingosine-1-phosphate (SPP) has attracted much attention as a possible second messenger controlling cell proliferation and motility and as an intracellular…”
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Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh) by Wellner‐Kienitz, Marie‐Cécile, Bender, Kirsten, Rinne, Andreas, Pott, Lutz

“…In this study we have investigated the voltage dependence of ATP-dependent K + current ( I K(ATP) ) in atrial and ventricular myocytes from hearts of adult…”
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Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow by Kirsten Bender, Marie-Cécile Wellner-Kienitz, Leif I Bösche, Andreas Rinne, Christian Beckmann, Lutz Pott

“…We have investigated the acute desensitization of acetylcholine-activated GIRK current ( I K(ACh) ) in cultured adult rat atrial myocytes. Acute…”
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G Protein-Independent Inhibition of GIRK Current by Adenosine in Rat Atrial Myocytes Overexpressing A1 Receptors after Adenovirus-Mediated Gene Transfer by Bösche, Leif I., Wellner‐Kienitz, Marie‐Cécile, Bender, Kirsten, Pott, Lutz

“…G protein-activated inwardly rectifying K + (GIRK) channels, important regulators of membrane excitability in the heart and central nervous system, are…”
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Fluorescent Biosensors for Multiplexed Imaging of Phosphoinositide Dynamics by Hertel, Fabian, Li, Simin, Chen, Mingyuan, Pott, Lutz, Mehta, Sohum, Zhang, Jin

“…Phosphoinositides constitute a critical family of lipids that regulate numerous cellular processes. Phosphatidylinositol 4,5-bisphosphate (PIP2) is arguably…”
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Overexpression of β1 and β2Adrenergic Receptors in Rat Atrial Myocytes by Wellner-Kienitz, Marie-Cécile, Bender, Kirsten, Pott, Lutz

“…G protein-activated inwardly rectifying K+ (GIRK) channels, expressed in atrial myocytes, various neurons, and endocrine cells, represent the paradigmatic…”
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Biased signaling of Ca2+-sensing receptors in cardiac myocytes regulates GIRK channel activity by Kienitz, Marie-Cecile, Niemeyer, Anne, König, Gabriele M., Kostenis, Evi, Pott, Lutz, Rinne, Andreas

“…Ca2+-sensing receptors (CaSRs) belong to the class C of G protein-coupled receptors and are activated by extracellular Ca2+. CaSRs display biased G protein…”
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Novel Kv7.1-Phosphatidylinositol 4,5-Bisphosphate Interaction Sites Uncovered by Charge Neutralization Scanning by Eckey, Karina, Wrobel, Eva, Strutz-Seebohm, Nathalie, Pott, Lutz, Schmitt, Nicole, Seebohm, Guiscard

“…Kv7.1 to Kv7.5 α-subunits belong to the family of voltage-gated potassium channels (Kv). Assembled with the β-subunit KCNE1, Kv7.1 conducts the slowly…”
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Receptor Species-Dependent Signaling of Gqpcrs Controls IKs Activity by Kienitz, Marie-Cecile, Vladimirova, Dilyana, Pott, Lutz, Rinne, Andreas

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Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors by Kienitz, Marie-Cécile, Vladimirova, Dilyana, Müller, Christian, Pott, Lutz, Rinne, Andreas

“…Activation of Gq protein-coupled receptors (GqPCRs) might induce divergent cellular responses, related to receptor-specific activation of different branches of…”
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G Protein Signaling of Ca2+-Sensing Receptors (CaSRs) in Cardiac Myocytes by Kienitz, Marie-Cecile, Schmidt, Jennifer, König, Gabriele, Kostenis, Evi, Pott, Lutz, Rinne, Andreas

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Impaired Na+ -dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation by Voigt, Niels, Heijman, Jordi, Trausch, Anne, Mintert-Jancke, Elisa, Pott, Lutz, Ravens, Ursula, Dobrev, Dobromir

“…Abstract Shortened action-potential duration (APD) and blunted APD rate adaptation are hallmarks of chronic atrial fibrillation (cAF). Basal and muscarinic…”
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