Search Results - "POTHOULAKIS, C"

Review article: anti‐inflammatory mechanisms of action of Saccharomyces boulardii by POTHOULAKIS, C.

“…Aliment Pharmacol Ther 30, 826–833 Summary Background  Saccharomyces boulardii, a well‐studied probiotic, can be effective in inflammatory gastrointestinal…”
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Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis by Shih, D Q, Zheng, L, Zhang, X, Zhang, H, Kanazawa, Y, Ichikawa, R, Wallace, K L, Chen, J, Pothoulakis, C, Koon, H W, Targan, S R

“…Intestinal fibrostenosis is among the hallmarks of severe Crohn’s disease. Patients with certain TNFSF15 (gene name for TL1A) variants over-express TL1A and…”
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Genome‐wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome by Mahurkar, S., Polytarchou, C., Iliopoulos, D., Pothoulakis, C., Mayer, E. A., Chang, L.

“…Background Irritable bowel syndrome (IBS) is a stress‐sensitive disorder. Environmental factors including stress can trigger epigenetic changes, which have not…”
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Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress by Bradesi, Sylvie, Svensson, Camilla I, Steinauer, Joanne, Pothoulakis, Charalabos, Yaksh, Tony L, Mayer, Emeran A

“…Background & Aims Chronic psychological stress is associated with visceral hyperalgesia and increased expression of spinal NK1 receptors (NK1Rs). We aimed to…”
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Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice by QAMAR, Amir, ABOUDOLA, Samer, WARNY, Michel, MICHETTI, Pierre, POTHOULAKIS, Charalabos, LAMONT, J. Thomas, KELLY, Ciaran P

“…Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The…”
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Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice by Kokkotou, E, Espinoza, D O, Torres, D, Karagiannides, I, Kosteletos, S, Savidge, T, O'Brien, M, Pothoulakis, C

“…Melanin-concentrating hormone (MCH) is a hypothalamic orexigenic neuropeptide that regulates energy balance. However, the distribution of MCH and its receptor…”
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Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells by Castagliuolo, I, Lamont, J T, Qiu, B, Fleming, S M, Bhaskar, K R, Nikulasson, S T, Kornetsky, C, Pothoulakis, C

“…We determined the effects of immobilization stress on rat colonic mucus release and mast cell degranulation and examined whether corticotropin releasing factor…”
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Intravenous immunoglobulin therapy for severe Clostridium difficile colitis by Salcedo, J, Keates, S, Pothoulakis, C, Warny, M, Castagliuolo, I, LaMont, J T, Kelly, C P

“…Background—Many individuals have serum antibodies against Clostridium difficile toxins. Those with an impaired antitoxin response may be susceptible to…”
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Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum by CASTAGLIUOLO, I, LAMONT, J. T, NIKULASSON, S. T, POTHOULAKIS, C

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Clostridium difficile toxin A causes early damage to mitochondria in cultured cells by He, D., Hagen, S.J., Pothoulakis, C., Chen, M., Medina, N.D., Warny, M., LaMont, J.T.

“…Background & Aims: The mechanism by which Clostridium difficile toxin A causes actin depolymerization and cell rounding involves toxin internalization and…”
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Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro by Riegler, M, Sedivy, R, Pothoulakis, C, Hamilton, G, Zacherl, J, Bischof, G, Cosentini, E, Feil, W, Schiessel, R, LaMont, J T

“…Toxin A but not toxin B, appears to mediate intestinal damage in animal models of Clostridium difficile enteritis. The purpose of this study was to investigate…”
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Direct evidence of mast cell involvement in Clostridium difficile toxin a—induced enteritis in mice by WERSHIL, B. K, CASTAGLIUOLO, I, POTHOULAKIS, C

“…Background & Aims: The pathogenesis of Clostridium difficile toxin A–induced intestinal inflammation is not completely understood. The aim of this study was to…”
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Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine by Warny, M, Fatimi, A, Bostwick, E F, Laine, D C, Lebel, F, LaMont, J T, Pothoulakis, C, Kelly, C P

“…Background Bovine immunoglobulin concentrate (BIC)-Clostridium difficile is prepared from the colostrum of cows immunised againstC difficile toxins and…”
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Protective effects of neurokinin‐1 receptor during colitis in mice: role of the epidermal growth factor receptor by Castagliuolo, I, Morteau, O, Keates, A C, Valenick, L, Wang, C ‐C, Zacks, J, Lu, B, Gerard, N P, Pothoulakis, C

“…The role of substance P and its high affinity neurokinin‐1 receptor in colitis has not been fully elucidated. We assessed the participation of neurokinin‐1…”
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CP-96,345, a Substance P Antagonist, Inhibits Rat Intestinal Responses to Clostridium difficile Toxin A but not Cholera Toxin by Pothoulakis, Charalabos, Castagliuolo, Ignazio, Lamont, J. Thomas, Jaffer, Amir, O'Keane, J. Conor, Snider, R. Michael, Leeman, Susan E.

“…Toxin A from Clostridium difficile mediates acute inflammatory enterocolitis in experimental animals, while cholera toxin causes noninflammatory secretory…”
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Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers by HECHT, G, POTHOULAKIS, C, LAMONT, T, MADARA, J. L

“…Toxin A of Clostridium difficile causes severe inflammatory enterocolitis in man and animals that appears to be mediated in part by acute inflammatory cells…”
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Enterotoxin A of Clostridium difficile and alpha-Gal epitopes by Pothoulakis, C

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Clostridium difficile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig by Xia, Y, Hu, H Z, Liu, S, Pothoulakis, C, Wood, J D

“…BACKGROUND AND AIMS Evidence suggests that the intestinal actions of Clostridium difficile toxin A—stimulation of secretion and motility, and an acute…”
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The role of neuroenteric hormones in intestinal infectious diseases by Pothoulakis, Charalabos

“…It is now well established that communication among the enteric nerves, hormones, and neuropeptides plays a role in the pathogenesis of infectious…”
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Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit by KELLY, C. P, BECKER, S, LINEVSKY, J. K, JOSHI, M. A, O'KEANE, J. C, DICKEY, B. F, LAMONT, J. T, POTHOULAKIS, C

“…Neutrophil infiltration is a prominent feature of Clostridium difficile-associated enteritis and colitis. The aim of this study was to examine the importance…”
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