Search Results - "POTEMPA, L. A"

Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia? by Slevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., Popa-Wagner, A., Love, S., Font, M. A., Potempa, L. A., Al-baradie, R., Sanfeliu, C., Revilla, S., Badimon, L., Krupinski, J.

“…Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue…”
Get full text

Loss of Pentameric Symmetry of C-Reactive Protein Is Associated with Promotion of Neutrophil-Endothelial Cell Adhesion by Zouki, Christine, Haas, Barbara, Chan, John S. D, Potempa, Lawrence A, Filep, Janos G

“…The classic acute-phase reactant C-reactive protein (CRP) is a cyclic pentameric protein that diminishes neutrophil accumulation in inflamed tissues. When the…”
Get full text

Complement regulation in innate immunity and the acute‐phase response: inhibition of mannan‐binding lectin‐initiated complement cytolysis by C‐reactive protein (CRP) by SUANKRATAY, C, MOLD, C, ZHANG, Y, POTEMPA, L. A, LINT, T. F, GEWURZ, H

“…Mannan‐binding lectin (MBL) is an acute‐phase protein which activates complement at the level of C4 and C2. We recently reported that the alternative pathway…”
Get full text

Identification and partial characterization of multiple native and neoantigenic epitopes of human C-reactive protein by using monoclonal antibodies by Ying, SC, Gewurz, H, Kinoshita, CM, Potempa, LA, Siegel, JN

“…Multiple mAb to human C-reactive protein (CRP) were prepared which reacted preferentially with either native CRP, modified CRP (expressing "neo-CRP"…”
Get full text

Deposition of Modified or Native C-Reactive Protein in Atherosclerotic Arteries? by Vaith, Peter, Potempa, Lawrence A

Get full text

Elucidation of a protease-sensitive site involved in the binding of calcium to C-reactive protein by Kinoshita, C. M, Ying, S. C, Hugli, T. E, Siegel, J. N, Potempa, L. A, Jiang, H, Houghten, R. A, Gewurz, H

“…C-reactive protein (CRP) is a Ca2+-binding protein composed of five identical 23-kDa subunits arranged as a cyclic pentamer, present in greatly elevated…”
Get full text

Stimulation of human neutrophils, monocytes, and platelets by modified C-reactive protein (CRP) expressing a neoantigenic specificity by POTEMPA, L. A, ZELLER, J. M, FIEDEL, B. A, KINOSHITA, C. M, GEWURZ, H

“…C-reactive protein (CRP) can be structurally modified by heat, acid, or urea-chelation to express a neoantigen designated by us as neo-CRP. This antigen is…”
Get full text

Immunohistochemical localization of modified C-reactive protein antigen in normal vascular tissue by Diehl, E E, Haines, 3rd, G K, Radosevich, J A, Potempa, L A

“…The prototypic acute phase reactant, C-reactive protein (CRP), is a serum soluble, cyclic pentameric protein, the concentration of which increases markedly…”
Get more information

Inhibition of mouse mammary adenocarcinoma (EMT6) growth and metastases in mice by a modified form of C-reactive protein by Kresl, J J, Potempa, L A, Anderson, B, Radosevich, J A

“…Mice were injected in the hind limb with a mouse mammary adenocarcinoma cell line, EMT6, and tumor growth at the primary site as well as the incidence of lung…”
Get more information

Expression, detection and assay of a neoantigen (Neo-CRP) associated with a free, human C-reactive protein subunit by Potempa, L A, Siegel, J N, Fiedel, B A, Potempa, R T, Gewurz, H

“…It has previously been reported that human C-reactive protein (CRP) can exist in at least two molecular conformations distinguished by antigenic,…”
Get more information

Complement activation by C-reactive protein on the HEp-2 cell substrate by Vaith, P, Prasauskas, V, Potempa, L A, Peter, H H

“…The complement (C) activation by C-reactive protein (CRP) in acute-phase sera is routinely tested in our laboratory by means of an indirect immunofluorescence…”
Get more information

Stimulation of megakaryocytopoiesis in mice by human modified C-reactive protein (mCRP) by Potempa, L A, Motie, M, Wright, K E, Crump, B L, Radosevich, J A, Sakai, N, Lai, G, Tanaka, K, Kojima, E, Tsuboi, A, Hua, L G

“…The prototypic human acute phase reactant, C-reactive protein (CRP), and a structurally modified form of CRP (mCRP) were studied as agents which could…”
Get more information

C-reactive protein antigenicity on the surface of human peripheral blood lymphocytes. Characterization of lymphocytes reactive with anti- neo-CRP by Bray, RA, Samberg, NL, Gewurz, H, Potempa, LA, Landay, AL

“…Previously, we have shown that antibodies specific for C-reactive protein determinants, not present on the native molecule, termed neo-CRP, also react with a…”
Get full text

Effect of divalent metal ions and pH upon the binding reactivity of human serum amyloid P component, a C-reactive protein homologue, for zymosan. Preferential reactivity in the presence of copper and acidic pH by Potempa, L A, Kubak, B M, Gewurz, H

“…The serum amyloid P component (SAP) has been found to associate in vitro with a variety of polysaccharide and proteinaceous ligands including the yeast cell…”
Get full text

Binding reactivity of C-reactive protein for polycations by DiCamelli, R, Potempa, L A, Siegel, J, Suyehira, L, Petras, K, Gewurz, H

Get full text

An appraisal of polystyrene-(ELISA) and nitrocellulose-based (ELIFA) enzyme immunoassay systems using monoclonal antibodies reactive toward antigenically distinct forms of human C-reactive protein by Shields, M J, Siegel, J N, Clark, C R, Hines, K K, Potempa, L A, Gewurz, H, Anderson, B

“…The purpose of this study was to compare and contrast two enzyme immunoassay systems: the enzyme-linked immunosorbent assay (ELISA), which utilizes polystyrene…”
Get more information

Conversion of native oligomeric to a modified monomeric form of human C-reactive protein by Kresl, John J, Potempa, Lawrence A, Anderson, Byron E

“…C-reactive protein (CRP) is a pentameric oligoprotein composed of identical 23 kD subunits which can be modified by urea-chelation treatment to a form…”
Get full text

Antigenic, electrophoretic and binding alterations of human C-reactive protein modified selectively in the absence of calcium by Potempa, L A, Maldonado, B A, Laurent, P, Zemel, E S, Gewurz, H

“…C-Reactive protein (CRP) is a trace component of normal human serum which has a mol. wt of 105,000 and is composed of five apparently identical subunits…”
Get more information

Binding of model soluble immune complexes to modified C-reactive protein by Motie, M, Brockmeier, S, Potempa, LA

“…We have identified a binding interaction between a modified form of C-reactive protein (mCRP) and model immune complexes. We have characterized these…”
Get full text

Biodistribution and clearance of 125I-labeled C-reactive protein and 125I-labeled modified C-reactive protein in CD-1 mice by MOTIE, M, SCHAUL, K. W, POTEMPA, L. A

“…Iodinated forms of C-reactive protein (CRP), soluble modified CRP (mCRP-sol), and suspended mCRP (mCRP-susp) were injected iv into CD-1 mice, for analysis of…”
Get full text