Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways

Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of about 15%.1 The importance of the genetic component is well accepted,2 but the mode of inheritance is complex and non-Mendelian. A line of evidence suggests the involvement of serotonin and dopamine neurot...

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Published in:	Molecular psychiatry Vol. 4; no. 4; pp. 389 - 392
Main Authors:	FRISCH, A, POSTILNICK, D, SCHNEIDMAN, M, MODAI, I, WEIZMAN, R, ROCKAH, R, MICHAELOVSKY, E, POSTILNICK, S, BIRMAN, E, LAOR, N, RAUCHVERGER, B, KREININ, A, POYUROVSKY, M
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-07-1999
Subjects:	Adult and adolescent clinical studies Alleles Antidepressants Biological and medical sciences Carrier Proteins - genetics Catechol Catechol O-Methyltransferase - genetics Depression Depressive Disorder - genetics Dopamine Dopamine - metabolism Dopamine D4 receptors Dopamine Plasma Membrane Transport Proteins Dopamine transporter Europe - ethnology Female Genotype Heredity Humans Israel Jews - genetics Male Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Mental depression Mood disorders Nerve Tissue Proteins Neurotransmitters Polymorphism, Genetic Promoter Regions, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Receptors, Dopamine D2 - genetics Receptors, Dopamine D4 Receptors, Serotonin - genetics Reference Values Serotonin Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins Serotonin transporter Tryptophan Tryptophan hydroxylase Tryptophan Hydroxylase - genetics Europe Israel Mood disorder Human Dopaminergic transmission Serotoninergic transmission Gene Risk factor Depression Genetics Genetic determinism Neurotransmission Polymorphism
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Summary:	Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of about 15%.1 The importance of the genetic component is well accepted,2 but the mode of inheritance is complex and non-Mendelian. A line of evidence suggests the involvement of serotonin and dopamine neurotransmitters in the pathophysiology of depression. In the present study, 102 unipolar MDD patients and 172 healthy controls were genotyped for polymorphisms in four serotonergic and three dopaminergic candidate genes [tryptophan hydroxylase (TPH), serotonin receptor 2A (HTR2A), serotonin receptor 2C (HTR2C), serotonin transporter promoter region (5-HTTLPR), dopamine receptor D4 (DRD4), dopamine transporter (DAT1) and catechol-O-methyl transferase (COMT)]. There were no statistical differences between MDD patients and healthy controls in the genotypic and allelic distribution of all polymorphisms investigated. Thus, our study does not support a major role for these polymorphisms in contributing to susceptibility to MDD, although it does not preclude minor effects.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1359-4184 1476-5578
DOI:	10.1038/sj.mp.4000536