Search Results - "POSPISILIK, J. Andrew"

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism by Haschemi, Arvand, Kosma, Paul, Gille, Lars, Evans, Charles R., Burant, Charles F., Starkl, Philipp, Knapp, Bernhard, Haas, Robert, Schmid, Johannes A., Jandl, Christoph, Amir, Shahzada, Lubec, Gert, Park, Jaehong, Esterbauer, Harald, Bilban, Martin, Brizuela, Leonardo, Pospisilik, J. Andrew, Otterbein, Leo E., Wagner, Oswald

“…Immune cells are somewhat unique in that activation responses can alter quantitative phenotypes upwards of 100,000-fold. To date little is known about the…”
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Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity by Öst, Anita, Lempradl, Adelheid, Casas, Eduard, Weigert, Melanie, Tiko, Theodor, Deniz, Merdin, Pantano, Lorena, Boenisch, Ulrike, Itskov, Pavel M., Stoeckius, Marlon, Ruf, Marius, Rajewsky, Nikolaus, Reuter, Gunter, Iovino, Nicola, Ribeiro, Carlos, Alenius, Mattias, Heyne, Steffen, Vavouri, Tanya, Pospisilik, J. Andrew

“…The global rise in obesity has revitalized a search for genetic and epigenetic factors underlying the disease. We present a Drosophila model of…”
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Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson's Disease by Li, Peipei, Killinger, Bryan A, Ensink, Elizabeth, Beddows, Ian, Yilmaz, Ali, Lubben, Noah, Lamp, Jared, Schilthuis, Meghan, Vega, Irving E, Woltjer, Randy, Pospisilik, J Andrew, Brundin, Patrik, Brundin, Lena, Graham, Stewart F, Labrie, Viviane

“…The gut microbiome can impact brain health and is altered in Parkinson's disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in…”
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Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man by Jais, Alexander, Einwallner, Elisa, Sharif, Omar, Gossens, Klaus, Lu, Tess Tsai-Hsiu, Soyal, Selma M., Medgyesi, David, Neureiter, Daniel, Paier-Pourani, Jamile, Dalgaard, Kevin, Duvigneau, J. Catharina, Lindroos-Christensen, Josefine, Zapf, Thea-Christin, Amann, Sabine, Saluzzo, Simona, Jantscher, Florian, Stiedl, Patricia, Todoric, Jelena, Martins, Rui, Oberkofler, Hannes, Müller, Simone, Hauser-Kronberger, Cornelia, Kenner, Lukas, Casanova, Emilio, Sutterlüty-Fall, Hedwig, Bilban, Martin, Miller, Karl, Kozlov, Andrey V., Krempler, Franz, Knapp, Sylvia, Lumeng, Carey N., Patsch, Wolfgang, Wagner, Oswald, Pospisilik, J. Andrew, Esterbauer, Harald

“…Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the two conditions do not always coincide and the molecular…”
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Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity by Dalgaard, Kevin, Landgraf, Kathrin, Heyne, Steffen, Lempradl, Adelheid, Longinotto, John, Gossens, Klaus, Ruf, Marius, Orthofer, Michael, Strogantsev, Ruslan, Selvaraj, Madhan, Lu, Tess Tsai-Hsiu, Casas, Eduard, Teperino, Raffaele, Surani, M. Azim, Zvetkova, Ilona, Rimmington, Debra, Tung, Y.C. Loraine, Lam, Brian, Larder, Rachel, Yeo, Giles S.H., O’Rahilly, Stephen, Vavouri, Tanya, Whitelaw, Emma, Penninger, Josef M., Jenuwein, Thomas, Cheung, Ching-Lung, Ferguson-Smith, Anne C., Coll, Anthony P., Körner, Antje, Pospisilik, J. Andrew

“…More than one-half billion people are obese, and despite progress in genetic research, much of the heritability of obesity remains enigmatic. Here, we identify…”
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Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity by Cimino, Irene, Rimmington, Debra, Tung, Y. C. Loraine, Lawler, Katherine, Larraufie, Pierre, Kay, Richard G., Virtue, Samuel, Lam, Brian Y. H., Fagnocchi, Luca, Ma, Marcella K. L., Saudek, Vladimir, Zvetkova, Ilona, Vidal-Puig, Antonio, Yeo, Giles S. H., Farooqi, I. Sadaf, Pospisilik, J. Andrew, Gribble, Fiona M., Reimann, Frank, O’Rahilly, Stephen, Coll, Anthony P.

“…Neuronatin ( Nnat ) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28…”
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Sequence features of retrotransposons allow for epigenetic variability by Costello, Kevin R, Leung, Amy, Trac, Candi, Lee, Michael, Basam, Mudaser, Pospisilik, J Andrew, Schones, Dustin E

“…Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes…”
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The DECON pilot project investigates predictive markers for successful bariatric surgery by Seifert, Gabriel, Fagnocchi, Luca, Edozie, Michael, Herrmann, Stephan, Baumann, Hannah, Panzeri, Ilaria, Mewes, Stephanie, Aicher, David, Runkel, Mira, Lässle, Claudia, Fink, Jodok, Marjanovic, Goran, Fichtner-Feigl, Stephan, Pospisilik, J. Andrew

“…Obesity is a chronic, multifactorial disease which is linked to a number of adverse endocrinological and metabolic conditions. Currently, bariatric surgery is…”
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Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection by Cronin, Shane J.F, Nehme, Nadine T, Limmer, Stefanie, Liegeois, Samuel, Pospisilik, J. Andrew, Schramek, Daniel, Leibbrandt, Andreas, Simoes, Ricardo de Matos, Gruber, Susanne, Puc, Urszula, Ebersberger, Ingo, Zoranovic, Tamara, Neely, G. Gregory, von Haeseler, Arndt, Ferrandon, Dominique, Penninger, Josef M

“…Innate immunity represents the first line of defense in animals. We report a genome-wide in vivo Drosophila RNA interference screen to uncover genes involved…”
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Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring by Burmeister, Amanda R., Gordevicius, Juozas, Paul, Emmanuel N., Houck, Christina, George, Sonia, Escobar Galvis, Martha L., Sha, Qiong, Brundin, Patrik, Pospisilik, J. Andrew, Racicot, Karen, Brundin, Lena

“…Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated. The vast majority…”
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The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy by Boneva, Stefaniya K., Wolf, Julian, Jung, Malte, Prinz, Gabriele, Chui, Toco Y. P., Jauch, Jacqueline, Drougard, Anne, Pospisilik, J. Andrew, Schlecht, Anja, Bucher, Felicitas, Rosen, Richard B., Agostini, Hansjürgen, Schlunck, Günther, Lange, Clemens A. K.

“…Abstract Background Despite great advances in proliferative diabetic retinopathy (PDR) therapy over the last decades, one third of treated patients continue to…”
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Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice by Mueller, Kristina M., Kornfeld, Jan‐Wilhelm, Friedbichler, Katrin, Blaas, Leander, Egger, Gerda, Esterbauer, Harald, Hasselblatt, Peter, Schlederer, Michaela, Haindl, Susanne, Wagner, Kay‐Uwe, Engblom, David, Haemmerle, Guenter, Kratky, Dagmar, Sexl, Veronika, Kenner, Lukas, Kozlov, Andrey V., Terracciano, Luigi, Zechner, Rudolf, Schuetz, Guenther, Casanova, Emilio, Pospisilik, J. Andrew, Heim, Markus H., Moriggl, Richard

“…Growth hormone (GH)‐activated signal transducer and activator of transcription 5 (STAT5) and the glucocorticoid (GC)‐responsive glucocorticoid receptor (GR)…”
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Association of parental obesity with the profile of metabolic-bariatric surgery patients: a cohort study of the German StuDoQ|MBE registry by Herrmann, Stephan, Fink, Mira, Fagnocchi, Luca, Matsuo, Koji, Fink, Jodok, Lässle, Claudia, Marjanovic, Goran, Fichtner-Feigl, Stefan, Pospisilik, J Andrew, Seifert, Gabriel

“…ObjectivesTo investigate the association of parental obesity (PO) with onset of obesity, pre-surgical disease duration and body mass index (BMI) at the time of…”
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Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes by Pospisilik, J. Andrew, Knauf, Claude, Joza, Nicholas, Benit, Paule, Orthofer, Michael, Cani, Patrice D., Ebersberger, Ingo, Nakashima, Tomoki, Sarao, Renu, Neely, Gregory, Esterbauer, Harald, Kozlov, Andrey, Kahn, C. Ronald, Kroemer, Guido, Rustin, Pierre, Burcelin, Remy, Penninger, Josef M.

“…Type-2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion. Recent studies place altered…”
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A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function by Neely, G. Gregory, Kuba, Keiji, Cammarato, Anthony, Isobe, Kazuya, Amann, Sabine, Zhang, Liyong, Murata, Mitsushige, Elmén, Lisa, Gupta, Vaijayanti, Arora, Suchir, Sarangi, Rinku, Dan, Debasis, Fujisawa, Susumu, Usami, Takako, Xia, Cui-ping, Keene, Alex C., Alayari, Nakissa N., Yamakawa, Hiroyuki, Elling, Ulrich, Berger, Christian, Novatchkova, Maria, Koglgruber, Rubina, Fukuda, Keiichi, Nishina, Hiroshi, Isobe, Mitsuaki, Pospisilik, J. Andrew, Imai, Yumiko, Pfeufer, Arne, Hicks, Andrew A., Pramstaller, Peter P., Subramaniam, Sai, Kimura, Akinori, Ocorr, Karen, Bodmer, Rolf, Penninger, Josef M.

“…Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061…”
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Human but Not Mouse Adipogenesis Is Critically Dependent on LMO3 by Lindroos, Josefine, Husa, Julia, Mitterer, Gerfried, Haschemi, Arvand, Rauscher, Sabine, Haas, Robert, Gröger, Marion, Loewe, Robert, Kohrgruber, Norbert, Schrögendorfer, Klaus F., Prager, Gerhard, Beck, Harald, Pospisilik, J. Andrew, Zeyda, Maximilian, Stulnig, Thomas M., Patsch, Wolfgang, Wagner, Oswald, Esterbauer, Harald, Bilban, Martin

“…Increased visceral fat is associated with a high risk of diabetes and metabolic syndrome and is in part caused by excessive glucocorticoids (GCs). However, the…”
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The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression by Penninger, Josef M, Schramek, Daniel, Kotsinas, Athanassios, Meixner, Arabella, Wada, Teiji, Elling, Ulrich, Pospisilik, J Andrew, Neely, G Gregory, Zwick, Ralf-Harun, Sigl, Verena, Forni, Guido, Serrano, Manuel, Gorgoulis, Vassilis G

“…Josef Penninger and colleagues show that deletion of the stress kinase MKK7 in mouse models of lung and mammary tumors accelerates tumor onset and reduces…”
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Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity by Timper, Katharina, Paeger, Lars, Sánchez-Lasheras, Carmen, Varela, Luis, Jais, Alexander, Nolte, Hendrik, Vogt, Merly C., Hausen, A. Christine, Heilinger, Christian, Evers, Nadine, Pospisilik, J. Andrew, Penninger, Josef M., Taylor, Eric B., Horvath, Tamas L., Kloppenburg, Peter, Brüning, Jens Claus

“…Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin…”
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Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1 by Nackiewicz, Dominika, Dan, Meixia, Speck, Madeleine, Chow, Samuel Z., Chen, Yi-Chun, Pospisilik, J. Andrew, Verchere, C. Bruce, Ehses, Jan A.

“…Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet…”
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Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice by Duparc, Thibaut, Colom, André, Cani, Patrice D, Massaly, Nicolas, Rastrelli, Sophie, Drougard, Anne, Le Gonidec, Sophie, Moulédous, Lionel, Frances, Bernard, Leclercq, Isabelle, Llorens-Cortes, Catherine, Pospisilik, J Andrew, Delzenne, Nathalie M, Valet, Philippe, Castan-Laurell, Isabelle, Knauf, Claude

“…Apelin and its receptor have emerged as promising targets for the treatment of insulin resistance. Indeed, peripheral administration of apelin stimulates…”
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