Search Results - "POSERN, G"

Gene regulation and deregulation by MAL/MRTF coactivators by Posern, G

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P1262: EZH2 INHIBITORS MEDIATE PLATINUM RESISTANCE BY ENHANCED EFFLUX by Groß, E., Hilger, R.‐A., Wehde, J., Schümann, F. L., Rohde, C., Willscher, E., Lützkendorf, J., Müller, L. P., Edemir, B., Müller, T., Binder, M., Posern, G., Weber, T.

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Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL by Miralles, Francesc, Posern, Guido, Zaromytidou, Alexia-Ileana, Treisman, Richard

“…Rho GTPases regulate the transcription factor SRF via their ability to induce actin polymerization. SRF activity responds to G actin, but the mechanism of this…”
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Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL by Posern, Guido, Miralles, Francesc, Guettler, Sebastian, Treisman, Richard

“…Nuclear accumulation of the serum response factor coactivator MAL/MKL1 is controlled by its interaction with G‐actin, which results in its retention in the…”
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Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor by Posern, Guido, Sotiropoulos, Athanassia, Treisman, Richard

“…Signal-induced activation of the transcription factor serum response factor (SRF) requires alterations in actin dynamics. SRF activity can be inhibited by…”
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Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL by Sakkab, Dima, Lewitzky, Marc, Posern, Guido, Schaeper, Ute, Sachs, Martin, Birchmeier, Walter, Feller, Stephan M.

“…Hepatocyte growth factor (HGF; scatter factor) is a multipotent protein with mitogenic, motogenic, and developmental functions. Upon activation, the…”
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Ras-independent Activation of the Raf/MEK/ERK Pathway upon Calcium-induced Differentiation of Keratinocytes by Schmidt, Marc, Goebeler, Matthias, Posern, Guido, Feller, Stephan M., Seitz, Cornelia S., Bröcker, Eva-B., Rapp, Ulf R., Ludwig, Stephan

“…MAPKs are crucially involved in the regulation of growth and differentiation of a variety of cells. To elucidate the role of MAPKs in keratinocyte…”
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Physiological signals and oncogenesis mediated through Crk family adapter proteins by Feller, Stephan M., Posern, Guido, Voss, Jan, Kardinal, Christian, Sakkab, Dima, Zheng, Jie, Knudsen, Beatrice S.

“…The viral Crk oncogene (v‐Crk) is known to induce sarcomas in chicken and its cellular homologs c‐Crk I, c‐Crk II, and Crk‐like (CRKL) have been implicated in…”
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Functional domains of interferon regulatory factor I (IRF-1) by Schaper, F, Kirchhoff, S, Posern, G, Köster, M, Oumard, A, Sharf, R, Levi, B Z, Hauser, H

“…Interferon (IFN) regulatory factors (IRFs) are a family of transcription factors among which are IRF-1, IRF-2, and IFN consensus sequence binding protein…”
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Tumour Necrosis Factor-α Promoter Polymorphism in Erythema Nodosum by Labunski, Svenja, Posern, Guido, Ludwig, Stephan, Kundt, G., Bröcker, Eva-B., Kunz, Manfred

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The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways by VOSS, J, POSERN, G, HANNEMANN, J. R, WIEDEMANN, L. M, TURHAN, A. G, POIREL, H, BERNARD, O. A, ADERMANN, K, KARDINAL, C, FELLER, S. M

“…Inappropriate activation of Abl family kinases plays a crucial role in different human leukaemias. In addition to the well known oncoproteins p190Bcr-Abl and…”
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Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients by Kardinal, C, Konkol, B, Schulz, A, Posern, G, Lin, H, Adermann, K, Eulitz, M, Estrov, Z, Talpaz, M, Arlinghaus, R B, Feller, S M

“…Bcr-Abl contributes prominently to the development of most chronic myeloid leukemias (CMLs). Prior work has identified the adapter protein CRKL as a major…”
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Activity of Rap1 Is Regulated by Bombesin, Cell Adhesion, and Cell Density in NIH3T3 Fibroblasts by Posern, Guido, Weber, Christoph K., Rapp, Ulf R., Feller, Stephan M.

“…Rap1 and Ras are homologous GTPases that are implicated in cell proliferation and differentiation. At present, little is known about the regulation of Rap1…”
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Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G by Posern, G, Zheng, J, Knudsen, B S, Kardinal, C, Müller, K B, Voss, J, Shishido, T, Cowburn, D, Cheng, G, Wang, B, Kruh, G D, Burrell, S K, Jacobson, C A, Lenz, D M, Zamborelli, T J, Adermann, K, Hanafusa, H, Feller, S M

“…Many Src Homology 3 (SH3) domains function as molecular adhesives in intracellular signal transduction. Based on previous ultrastructural studies, short motifs…”
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Rapid lamellipodia formation in nerve growth factor-stimulated PC12 cells is dependent on Rac and PI3K activity by Posern, Guido, Saffrich, Rainer, Ansorge, Wilhelm, Feller, Stephan M.

“…Neuronal differentiation of PC12 cells is achieved by stimulation with nerve growth factor (NGF) but not by epidermal growth factor (EGF). However, features of…”
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OTT-MAL is a deregulated activator of SRF-dependent gene expression by Descot, A., Rex-Haffner, M., Courtois, G., Bluteau, D., Menssen, A., Mercher, T., Bernard, O.A., Treisman, R., Posern, G.

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The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells by Posern, G, Rapp, U R, Feller, S M

“…Rap1 is a small GTPase implicated in cell proliferation and differentiation. The mechanisms how endogenous Rap1 is activated by many mitogenic stimuli…”
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Rational development of cell-penetrating high affinity SH3 domain binding peptides that selectively disrupt the signal transduction of Crk family adapters. Amgen Peptide Technology Group by Kardinal, C, Posern, G, Zheng, J, Knudsen, B S, Moarefi, I, Feller, S M

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Rational Development of Cell-Penetrating High Affinity SH3 Domain Binding Peptides That Selectively Disrupt the Signal Transduction of Crk Family Adapters by KARDINAL, CHRISTIAN, POSERN, GUIDO, ZHENG, JIE, KNUDSEN, BEATRICE S., MOAREFI, ISMAIL, FELLER, STEPHAN M.

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Tumour necrosis factor-alpha promoter polymorphism in erythema nodosum by Labunski, S, Posern, G, Ludwig, S, Kundt, G, Bröcker, E B, Kunz, M

“…Erythema nodosum is a common skin disease characterized by erythematous, tender subcutaneous nodules, mostly located on the lower extremities. Little is known…”
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