Search Results - "POSCH, Martin"

An international comparison of age and sex dependency of COVID-19 deaths in 2020: a descriptive analysis by Bauer, Peter, Brugger, Jonas, König, Franz, Posch, Martin

“…The number of reported coronavirus disease (COVID-19) deaths per 100,000 persons observed so far in 2020 is described in 15 European countries and the USA as…”
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Impact of adaptive filtering on power and false discovery rate in RNA-seq experiments by Zehetmayer, Sonja, Posch, Martin, Graf, Alexandra

“…Abstract Background In RNA-sequencing studies a large number of hypothesis tests are performed to compare the differential expression of genes between several…”
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Evaluation of the Fill-it-up-design to use historical control data in randomized clinical trials with two arm parallel group design by Wied, Stephanie, Posch, Martin, Hilgers, Ralf-Dieter

“…In the context of clinical research, there is an increasing need for new study designs that help to incorporate already available data. With the help of…”
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A graphical approach to sequentially rejective multiple test procedures by Bretz, Frank, Maurer, Willi, Brannath, Werner, Posch, Martin

“…For clinical trials with multiple treatment arms or endpoints a variety of sequentially rejective, weighted Bonferroni‐type tests have been proposed, such as…”
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Current Statistical Considerations and Regulatory Perspectives on the Planning of Confirmatory Basket, Umbrella, and Platform Trials by Collignon, Olivier, Gartner, Christian, Haidich, Anna‐Bettina, James Hemmings, Robert, Hofner, Benjamin, Pétavy, Frank, Posch, Martin, Rantell, Khadija, Roes, Kit, Schiel, Anja

“…Master protocols have received a growing interest during the last years. By assigning patients to specific substudies, they aim at targeting and accelerating…”
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A Randomized Trial of Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection by Eskandary, Farsad, Regele, Heinz, Baumann, Lukas, Bond, Gregor, Kozakowski, Nicolas, Wahrmann, Markus, Hidalgo, Luis G, Haslacher, Helmuth, Kaltenecker, Christopher C, Aretin, Marie-Bernadette, Oberbauer, Rainer, Posch, Martin, Staudenherz, Anton, Handisurya, Ammon, Reeve, Jeff, Halloran, Philip F, Böhmig, Georg A

“…Late antibody-mediated rejection (ABMR) is a leading cause of kidney allograft failure. Uncontrolled studies have suggested efficacy of the proteasome…”
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The Evolution of Master Protocol Clinical Trial Designs: A Systematic Literature Review by Meyer, Elias Laurin, Mesenbrink, Peter, Dunger-Baldauf, Cornelia, Fülle, Hans-Jürgen, Glimm, Ekkehard, Li, Yuhan, Posch, Martin, König, Franz

“…Recent years have seen a change in the way that clinical trials are being conducted. There has been a rise of designs more flexible than traditional adaptive…”
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Sample Size Reassessment and Hypothesis Testing in Adaptive Survival Trials by Magirr, Dominic, Jaki, Thomas, Koenig, Franz, Posch, Martin

“…Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error…”
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Adaptive designs for confirmatory clinical trials by Bretz, Frank, Koenig, Franz, Brannath, Werner, Glimm, Ekkehard, Posch, Martin

“…Adaptive designs play an increasingly important role in clinical drug development. Such designs use accumulating data of an ongoing trial to decide how to…”
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Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review by Ondra, Thomas, Dmitrienko, Alex, Friede, Tim, Graf, Alexandra, Miller, Frank, Stallard, Nigel, Posch, Martin

“…Important objectives in the development of stratified medicines include the identification and confirmation of subgroups of patients with a beneficial…”
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Subgroup identification in clinical trials via the predicted individual treatment effect by Ballarini, Nicolás M, Rosenkranz, Gerd K, Jaki, Thomas, König, Franz, Posch, Martin

“…Identifying subgroups of treatment responders through the different phases of clinical trials has the potential to increase success in drug development. Recent…”
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On model-based time trend adjustments in platform trials with non-concurrent controls by Bofill Roig, Marta, Krotka, Pavla, Burman, Carl-Fredrik, Glimm, Ekkehard, Gold, Stefan M, Hees, Katharina, Jacko, Peter, Koenig, Franz, Magirr, Dominic, Mesenbrink, Peter, Viele, Kert, Posch, Martin

“…Platform trials can evaluate the efficacy of several experimental treatments compared to a control. The number of experimental treatments is not fixed, as arms…”
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On the use of non-concurrent controls in platform trials: a scoping review by Bofill Roig, Marta, Burgwinkel, Cora, Garczarek, Ursula, Koenig, Franz, Posch, Martin, Nguyen, Quynh, Hees, Katharina

“…Platform trials gained popularity during the last few years as they increase flexibility compared to multi-arm trials by allowing new experimental arms…”
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Analysis of the specificity of a COVID-19 antigen test in the Slovak mass testing program by Hledík, Michal, Polechová, Jitka, Beiglböck, Mathias, Herdina, Anna Nele, Strassl, Robert, Posch, Martin

“…Mass antigen testing programs have been challenged because of an alleged insufficient specificity, leading to a large number of false positives. The objective…”
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Efficiency of multivariate tests in trials in progressive supranuclear palsy by Yousefi, Elham, Gewily, Mohamed, König, Franz, Höglinger, Günter, Hopfner, Franziska, Karlsson, Mats O., Ristl, Robin, Zehetmayer, Sonja, Posch, Martin

“…Measuring disease progression in clinical trials for testing novel treatments for multifaceted diseases as progressive supranuclear palsy (PSP), remains…”
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Fallback tests for co-primary endpoints by Ristl, Robin, Frommlet, Florian, Koch, Armin, Posch, Martin

“…When efficacy of a treatment is measured by co‐primary endpoints, efficacy is claimed only if for each endpoint an individual statistical test is significant…”
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Association of immediate versus delayed extubation of patients admitted to intensive care units postoperatively and outcomes: A retrospective study by Zajic, Paul, Eichinger, Michael, Eichlseder, Michael, Hallmann, Barbara, Honnef, Gabriel, Fellinger, Tobias, Metnitz, Barbara, Posch, Martin, Rief, Martin, Metnitz, Philipp G H

“…This study seeks to investigate, whether extubation of tracheally intubated patients admitted to intensive care units (ICU) postoperatively either immediately…”
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Red blood cell transfusion-related dynamics of extracellular vesicles in intensive care patients: a prospective subanalysis by Raeven, Pierre, Karlhofer, Katharina, Sztulman, Larissa S., Brugger, Jonas, Hoetzenecker, Konrad, Domenig, Christoph, Leitner, Gerda, Posch, Martin, Baron, David M., Spittler, Andreas

“…Extracellular vesicles (EVs) accumulate during packed red blood cell (PRBC) storage. To date, the involvement of EVs in transfusion-related immunomodulation…”
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Nationwide analysis of hospital admissions and outcomes of patients with SARS-CoV-2 infection in Austria in 2020 and 2021 by Zajic, Paul, Hiesmayr, Michael, Bauer, Peter, Baron, David M., Gruber, Anastasiia, Joannidis, Michael, Posch, Martin, Metnitz, Philipp G. H.

“…This retrospective study evaluated temporal and regional trends of patient admissions to hospitals, intensive care units (ICU), and intermediate care units…”
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Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests by Bretz, Frank, Posch, Martin, Glimm, Ekkehard, Klinglmueller, Florian, Maurer, Willi, Rohmeyer, Kornelius

“…The confirmatory analysis of pre‐specified multiple hypotheses has become common in pivotal clinical trials. In the recent past multiple test procedures have…”
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