Search Results - "PORTNOY, Y. A"

The Antistaphylococcal Pharmacodynamics of Linezolid Alone and in Combination with Doxycycline in an In Vitro Dynamic Model by Smirnova, M.V., Strukova, E.N., Portnoy, Y.A., Dovzhenko, S.A., Kobrin, M.B., Zinner, S.H., Firsov, A.A.

“…To delineate the possible advantages of linezolid/doxycycline combinations over either drug alone, the in vitro pharmacodynamics of linezolid, doxycycline and…”
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Antibiotic Combinations Preventing Bacterial Resistance: Studies on an in vitro Model with Staphylococcus aureus Exposed to Linezolid–Daptomycin by K. N. Alieva, M. V. Golikova, Y. A. Portnoy, A. A. Firsov

“…To predict the anti-mutant effects of antibiotic combinations against Staphylococcus aureus, the mutant prevention concentrations (MPCs) of linezolid and…”
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Relationships of the Area under the Curve/MIC Ratio to Different Integral Endpoints of the Antimicrobial Effect: Gemifloxacin Pharmacodynamics in an In Vitro Dynamic Model by FIRSOV, Alexander A, LUBENKO, Irene Y, PORTNOY, Yury A, ZINNER, Stephen H, VOSTROV, Sergey N

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PK/PD Modeling as a Tool for Predicting Bacterial Resistance to Antibiotics: Alternative Analyses of Experimental Data by Golikova, M V, Strukova, E N, Portnoy, Y A, Firsov, A A

“…Postexposure number of mutants (NM) is a conventional endpoint in bacterial resistance studies using in vitro dynamic models that simulate antibiotic…”
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Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model by FIRSOV, A. A, VOSTROV, S. N, KONONENKO, O. V, ZINNER, S. H, PORTNOY, Y. A

“…The effect of inoculum size (N0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its…”
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Comparative pharmacodynamics of moxifloxacin and levofloxacin in an in vitro dynamic model: prediction of the equivalent AUC/MIC breakpoints and equiefficient doses by Firsov, Alexander A., Lubenko, Irene Yu, Vostrov, Sergey N., Kononenko, Olga V., Zinner, Stephen H., Portnoy, Yury A.

“…To demonstrate the impact of the different pharmacokinetics of moxifloxacin and levofloxacin on their antimicrobial effects (AMEs), killing and regrowth…”
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Antibiotic Combinations Preventing Bacterial Resistance: Studies on an in vitro Model with Staphylococcus aureus Exposed to Linezolid–Daptomycin by K. N. Alieva, M. V. Golikova, Y. A. Portnoy, A. A. Firsov

“…To predict the anti-mutant effects of antibiotic combinations against Staphylococcus aureus, the mutant prevention concentrations (MPCs) of linezolid and…”
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PK/PD Modeling as a Tool for Predicting Bacterial Resistance to Antibiotics: Alternative Analyses of Experimental Data by M. V. Golikova, E. N. Strukova, Y. A. Portnoy, A. A. Firsov

“…Postexposure number of mutants (NM) is a conventional endpoint in bacterial resistance studies using in vitro dynamic models that simulate antibiotic…”
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A New Approach to In Vitro Comparisons of Antibiotics in Dynamic Models: Equivalent Area under the Curve/MIC Breakpoints and Equiefficient Doses of Trovafloxacin and Ciprofloxacin against Bacteria of Similar Susceptibilities by FIRSOV, A. A, VOSTROV, S. N, SHEVCHENKO, A. A, PORTNOY, Yu. A, ZINNER, S. H

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The scientific path of Corresponding Member of the RAS, Professor A. A. Firsop by Y. A. Portnoy, M. V. Golikova

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Concentration-resistance relationships with Pseudomonas aeruginosa exposed to doripenem and ciprofloxacin in an in vitro model by Zinner, Stephen H, Gilbert, Deborah, Greer, Kenneth, Portnoy, Yury A, Firsov, Alexander A

“…To compare the abilities of doripenem and ciprofloxacin to restrict the enrichment of resistant Pseudomonas aeruginosa, multiple antibiotic dosing regimens…”
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Concentration-dependent changes in the susceptibility and killing of Staphylococcus aureus in an in vitro dynamic model that simulates normal and impaired gatifloxacin elimination by Firsov, Alexander A, Vostrov, Sergey N, Lubenko, Irene Yu, Zinner, Stephen H, Portnoy, Yury A

“…To demonstrate the impact of normal (NEK) and impaired elimination kinetics (IEK) of gatifloxacin on its ability to protect from losses in the susceptibility…”
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MIC-Based Interspecies Prediction of the Antimicrobial Effects of Ciprofloxacin on Bacteria of Different Susceptibilities in an In Vitro Dynamic Model by FIRSOV, A. A, VOSTROV, S. N, SHEVCHENKO, A. A, ZINNER, S. H, CORNAGLIA, G, PORTNOY, Yu. A

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Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model by Firsov, Alexander A., Smirnova, Maria V., Lubenko, Irene Yu, Vostrov, Sergey N., Portnoy, Yury A., Zinner, Stephen H.

“…Objectives: To extend the mutant selection window (MSW) hypothesis to include antibiotics in addition to fluoroquinolones, the pharmacodynamics of daptomycin…”
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Simulated in vitro quinolone pharmacodynamics at clinically achievable AUC/MIC ratios: advantage of I E over other integral parameters by Firsov, A A, Zinner, S H, Lubenko, I Y, Portnoy, Y A, Vostrov, S N

“…To compare the antimicrobial effects of clinically achievable ratios of area under the curve (AUC) to MIC, a clinical isolate of Moraxella catarrhalis was…”
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Comparative anti-staphylococcal effects of gemifloxacin and trovafloxacin in an in vitro dynamic model in terms of AUC/MIC and dose relationships by Zinner, Stephen H., Vostrov, Sergey N., Lubenko, Irene Yu, Portnoy, Yury A., Cornaglia, Giuseppe, Firsov, Alexander A.

“…To compare the antimicrobial effects of gemifloxacin and trovafloxacin on Staphylococcus aureus, their pharmacodynamics were studied in an in vitro dynamic…”
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The impact of duration of antibiotic exposure on bacterial resistance predictions using in vitro dynamic models by Smirnova, Maria V., Vostrov, Sergey N., Strukova, Elena V., Dovzhenko, Svetlana A., Kobrin, Michael B., Portnoy, Yury A., Zinner, Stephen H., Firsov, Alexander A.

“…Objectives To explore whether the duration of in vitro simulated antibiotic exposure influences bacterial resistance, time-dependent amplification of resistant…”
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Telavancin and vancomycin pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model by Lubenko, Irene Yu, Strukova, Elena V., Smirnova, Maria V., Vostrov, Sergey N., Portnoy, Yury A., Zinner, Stephen H., Firsov, Alexander A.

“…Objectives The aim of this study was to compare the pharmacodynamics of telavancin (TLV) and vancomycin (VAN) with Staphylococcus aureus. Their concentrations…”
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In Vitro Pharmacodynamic Evaluation of the Mutant Selection Window Hypothesis Using Four Fluoroquinolones against Staphylococcus aureus by FIRSOV, Alexander A, VOSTROV, Sergey N, LUBENKO, Irene Y, DRLICA, Karl, PORTNOY, Yury A, ZINNER, Stephen H

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ABT492 and levofloxacin: comparison of their pharmacodynamics and their abilities to prevent the selection of resistant Staphylococcus aureus in an in vitro dynamic model by Firsov, Alexander A., Vostrov, Sergey N., Lubenko, Irene Yu, Arzamastsev, Alexander P., Portnoy, Yury A., Zinner, Stephen H.

“…Objective: To compare the kinetics of killing/regrowth of differentially susceptible clinical isolates of Staphylococcus aureus exposed to ABT492 and…”
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