Search Results - "PORTEU, Francoise"

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response by Barbieri, Daniela, Elvira-Matelot, Emilie, Pelinski, Yanis, Genève, Laetitia, de Laval, Bérengère, Yogarajah, Gayathri, Pecquet, Christian, Constantinescu, Stefan N, Porteu, Françoise

“…Maintenance of genomic integrity is crucial for the preservation of hematopoietic stem cell (HSC) potential. Retrotransposons, spreading in the genome through…”
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NF-κB signaling controls H3K9me3 levels at intronic LINE-1 and hematopoietic stem cell genes in cis by Pelinski, Yanis, Hidaoui, Donia, Stolz, Anne, Hermetet, François, Chelbi, Rabie, Diop, M'boyba Khadija, Chioukh, Amir M, Porteu, Françoise, Elvira-Matelot, Emilie

“…Ionizing radiations (IR) alter hematopoietic stem cell (HSC) function on the long term, but the mechanisms underlying these effects are still poorly…”
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Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation by Djeghloul, Dounia, Kuranda, Klaudia, Kuzniak, Isabelle, Barbieri, Daniela, Naguibneva, Irina, Choisy, Caroline, Bories, Jean-Christophe, Dosquet, Christine, Pla, Marika, Vanneaux, Valérie, Socié, Gérard, Porteu, Françoise, Garrick, David, Goodhardt, Michele

“…The capacity of hematopoietic stem cells (HSC) to generate B lymphocytes declines with age, contributing to impaired immune function in the elderly. Here we…”
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Bone marrow niches in myeloid and lymphoid malignancies by Porteu, Françoise, Troadec, Marie-Bérengère

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The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent by Le Chapelain, Ophélie, Jadoui, Soumaya, Gros, Angèle, Barbaria, Samir, Benmeziane, Keltouma, Ollivier, Véronique, Dupont, Sébastien, Solo Nomenjanahary, Mialitiana, Mavouna, Sabrina, Rogozarski, Jasmina, Mawhin, Marie-Anne, Caligiuri, Giuseppina, Delbosc, Sandrine, Porteu, Françoise, Nieswandt, Bernhard, Mangin, Pierre H, Boulaftali, Yacine, Ho-Tin-Noé, Benoit

“…How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized. We compared the presence and participation of…”
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SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice by Willekens, Christophe, Laplane, Lucie, Dagher, Tracy, Benlabiod, Camelia, Papadopoulos, Nicolas, Lacout, Catherine, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Edmond, Valérie, Signolle, Nicolas, Marchand, Valentine, Droin, Nathalie, Hoogenboezem, Remco, Schneider, Rebekka K., Penson, Alex, Abdel-Wahab, Omar, Giraudier, Stephane, Pasquier, Florence, Marty, Caroline, Plo, Isabelle, Villeval, Jean-Luc, Constantinescu, Stefan N., Porteu, Françoise, Vainchenker, William, Solary, Eric

“…Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2…”
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From normal hematopoiesis to malignancies: Highlights from the 2021 Meeting of the Club Hematopoiesis and Oncogenesis by Troadec, Marie-Bérengère, Porteu, Françoise, Arcangeli, Marie-Laure, Foudi, Adlen, Bluteau, Dominique, De Sepulveda, Paulo, Guillouf, Christel, Mazure, Nathalie M., Meggetto, Fabienne, Brunet De La Grange, Philippe, Broccardo, Cyril

“…This article highlights the presentations from the 2021 scientific meeting of the Club Hematopoiesis and Oncogenesis. This annual meeting focuses on…”
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The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis by Guihard, Soizic, Clay, Denis, Cocault, Laurence, Saulnier, Nathalie, Opolon, Paule, Souyri, Michèle, Pagès, Gilles, Pouysségur, Jacques, Porteu, Françoise, Gaudry, Murielle

“…The mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase 1 (ERK1) and ERK2 are among the main signal transduction molecules, but…”
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ERK1 regulates the hematopoietic stem cell niches by Saulnier, Nathalie, Guihard, Soizic, Holy, Xavier, Decembre, Elodie, Jurdic, Pierre, Clay, Denis, Feuillet, Vincent, Pagès, Gilles, Pouysségur, Jacques, Porteu, Françoise, Gaudry, Murielle

“…The mitogen-activated protein kinases (MAPK) ERK1 and ERK2 are among the major signal transduction molecules but little is known about their specific functions…”
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p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes by FRISAN, Emilie, PAWLIKOWSKA, Patrycja, PIERRE-EUGENE, Cecile, VIALLON, Vivian, GIBAULT, Laure, PARK, Sophie, MAYEUX, Patrick, DREYFUS, François, PORTEU, Françoise, FONTENAY, Michaëla

“…Serum erythropoietin level less than 100U/L and a transfusion requirement of less than 2 units per month are the best predictive factors for response to…”
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Interleukin‐18 produced by bone marrow‐derived stromal cells supports T‐cell acute leukaemia progression by Uzan, Benjamin, Poglio, Sandrine, Gerby, Bastien, Wu, Ching‐Lien, Gross, Julia, Armstrong, Florence, Calvo, Julien, Cahu, Xavier, Deswarte, Caroline, Dumont, Florent, Passaro, Diana, Besnard‐Guérin, Corinne, Leblanc, Thierry, Baruchel, André, Landman‐Parker, Judith, Ballerini, Paola, Baud, Véronique, Ghysdael, Jacques, Baleydier, Frédéric, Porteu, Francoise, Pflumio, Francoise

“…Development of novel therapies is critical for T‐cell acute leukaemia (T‐ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T‐ALL…”
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Gfi‐1B Promoter Remains Associated with Active Chromatin Marks Throughout Erythroid Differentiation of Human Primary Progenitor Cells by Laurent, Benoît, Randrianarison‐Huetz, Voahangy, Kadri, Zahra, Roméo, Paul‐Henri, Porteu, Françoise, Duménil, Dominique

“…Growth Factor Independent‐1B (Gfi‐1B) is a transcriptional repressor that plays critical roles in the control of erythropoiesis and megakaryopoiesis. Gfi‐1B…”
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Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting by Chour, Mohamed, Porteu, Françoise, Depil, Stéphane, Alcazer, Vincent

“…Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode…”
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The cancer chemopreventive agent resveratrol induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities by RODRIGUE, Christelle M, PORTEU, Francoise, NAVARRO, Nicole, BRUYNEEL, Erik, BRACKE, Marc, ROMEO, Paul-Henri, GESPACH, Christian, GAREL, Marie-Claude

“…During a search to identify resveratrol (3,5,4'-trihydroxy-trans-stilbene, RV) target genes in the human erythroleukemic K562 cell line, we show here that the…”
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3151 – THE SELECTIVE ADVANTAGE OF TET2-/- HSCS IS ASSOCIATED WITH AN EPIGENETIC SWITCH AT TRANSPOSABLE ELEMENTS THAT PROTECTS THEM FROM CHRONIC INFLAMMATION by STOLZ, Anne, Elvira-Matelot, Emilie, Porteu, Francoise

“…Clonal hematopoiesis of undetermined potential (CHIP) involves the expansion of mutated hematopoietic stem cells (HSCs) due to aging and inflammation,…”
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B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK by Letourneux, Claire, Rocher, Géraldine, Porteu, Françoise

“…The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal‐regulated kinase (ERK) signaling pathway but whether a specific…”
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Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo) by BOUSCARY, Didier, LECOQ-LAFON, Carinne, LACOMBE, Catherine, CHRETIEN, Stany, ZOMPI, Simona, FICHELSON, Serge, MULLER, Odile, PORTEU, Francoise, DUSANTER-FOURT, Isabelle, GISSELBRECHT, Sylvie, MAYEUX, Patrick

“…In this study, we show that upon thrombopoietin (Tpo) stimulation the two adapter proteins Gab1 and Gab2 are strongly tyrosine phosphorylated and associated…”
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Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1 by de Laval, Bérengère, Pawlikowska, Patrycja, Barbieri, Daniela, Besnard-Guerin, Corinne, Cico, Alba, Kumar, Rajiv, Gaudry, Murielle, Baud, Véronique, Porteu, Françoise

“…Loss of hematopoietic stem cell (HSC) function and increased risk of developing hematopoietic malignancies are severe and concerning complications of…”
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Thrombopoietin-Increased DNA-PK-Dependent DNA Repair Limits Hematopoietic Stem and Progenitor Cell Mutagenesis in Response to DNA Damage by de Laval, Bérengère, Pawlikowska, Patrycja, Petit-Cocault, Laurence, Bilhou-Nabera, Chrystèle, Aubin-Houzelstein, Geneviève, Souyri, Michèle, Pouzoulet, Frédéric, Gaudry, Murielle, Porteu, Françoise

“…DNA double-strand breaks (DSBs) represent a serious threat for hematopoietic stem cells (HSCs). How cytokines and environmental signals integrate the DNA…”
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Inhibition of B56-containing Protein Phosphatase 2As by the Early Response Gene IEX-1 Leads to Control of Akt Activity by Rocher, Gé;raldine, Letourneux, Claire, Lenormand, Philippe, Porteu, Françoise

“…The importance of PP2A in the regulation of Akt/PKB activity has long been recognized but the nature of the holoenzyme involved and the mechanisms controlling…”
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